{"title":"Brain \u0026 Focus Supplements","description":"\u003cp\u003eBrain Advantage, with lion's mane and citicoline, supports memory, focus and mental clarity.† If stress gets in the way of focus, CortiResponse helps maintain healthy cortisol levels and a sense of calm.† B-12 Essential Trio supports energy metabolism and a healthy nervous system.†\u003c\/p\u003e","products":[{"product_id":"b12-sublingual-essential-trio","title":"B-12 Essential Trio – B12, Folinate \u0026 B6 for Energy Metabolism | 2 fl oz Liquid","description":"\u003cp\u003e\u003cstrong\u003eB-12 Essential Trio is a blueberry-flavored liquid with three B vitamins. One serving (a single dropper bulb squeeze, about 0.84 grams) gives 2,000 mcg of vitamin B12 as methylcobalamin, 680 mcg DFE of folate as folinate and 4 mg of vitamin B6. Each 2 fl oz bottle holds 80 servings. Together, these vitamins support normal energy metabolism and healthy homocysteine metabolism.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB12 occurs naturally only in animal foods, so anyone eating little or no meat, fish, eggs or dairy may need another source. The NIH also advises people over 50 to get most of their B12 from fortified foods or supplements, since many older adults don't make enough stomach acid to free B12 from food (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-Consumer\/\"\u003ethe NIH's consumer guide to vitamin B12\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003eIf you're in your 30s or 40s and building habits so you can keep up at 75, half a dropper each morning is about as easy as a habit gets. No pills to swallow. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take B-12 Essential Trio\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports normal energy metabolism, because B12 and B6 are coenzymes your cells use to turn parts of protein and fat into fuel.†\u003c\/li\u003e\n\u003cli\u003eSupports healthy homocysteine levels already within the normal range, as B12 and folate recycle homocysteine into methionine.†\u003c\/li\u003e\n\u003cli\u003eSupports normal red blood cell formation and DNA synthesis, with folate and B12 working together.†\u003c\/li\u003e\n\u003cli\u003eSupports healthy nervous system function.†\u003c\/li\u003e\n\u003cli\u003eHelps people who eat few animal foods, and adults over 50, keep B12 intake up.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B6 (from Pyridoxine HCl)\u003c\/td\u003e\n\u003ctd\u003e4 mg\u003c\/td\u003e\n\u003ctd\u003e235%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFolinate (from Calcium Folinate)\u003c\/td\u003e\n\u003ctd\u003e680 mcg DFE\u003c\/td\u003e\n\u003ctd\u003e170%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B12 (Methylcobalamin)\u003c\/td\u003e\n\u003ctd\u003e2,000 mcg\u003c\/td\u003e\n\u003ctd\u003e83,333%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 1 Dropper Bulb Squeeze (Approximately half a dropper full, Approximately 0.84 grams). Servings per container: 80. Other ingredients: Vegetable Glycerin, Purified Water, Citric Acid, Potassium Sorbate, and Natural Blueberry Flavor. The label states: \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or artificial colors or flavors.\" It also says: \"Refrigerate after opening.\" Potassium sorbate is a preservative.\u003c\/p\u003e\n\u003ch2\u003eHow B-12 Essential Trio works\u003c\/h2\u003e\n\u003ch3\u003eMethylcobalamin (2,000 mcg): B12 for the methylation cycle\u003c\/h3\u003e\n\u003cp\u003eB12 is a coenzyme, a helper molecule two enzymes can't work without, and methylcobalamin is one of the two forms your cells use in that role (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e). It partners with methionine synthase, the enzyme that recycles homocysteine into methionine, which your body turns into SAMe, its most important methyl donor. That same step pulls a one-carbon unit off folate so folate can keep cycling into DNA building blocks, which is why B12 and folate come as a pair. B12's other coenzyme form helps your mitochondria turn leftovers from breaking down certain amino acids into fuel (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\"\u003eFroese et al., 2019\u003c\/a\u003e).†\u003c\/p\u003e\n\u003cp\u003eStraight talk: your cells process any B12 they absorb before using it, and the NIH says there's no evidence that absorption differs by form. We chose methylcobalamin because it's one of the two coenzyme forms, not because we can show it's absorbed or used better.\u003c\/p\u003e\n\u003ch3\u003eWhy 2,000 mcg when the Daily Value is 2.4 mcg\u003c\/h3\u003e\n\u003cp\u003eBecause the share you absorb drops as the dose rises: the NIH puts absorption near 50% for doses under 1 to 2 mcg but about 1.3% of a 1,000 mcg dose. A systematic review saw the same pattern with food: people absorbed 83% of a 3 mcg dose but only 4.5% of a 38 mcg dose (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23796635\/\"\u003eDoets et al., 2013\u003c\/a\u003e). A big dose offsets a small percentage.\u003c\/p\u003e\n\u003ch3\u003eFolinate (680 mcg DFE): folate that skips a slow step\u003c\/h3\u003e\n\u003cp\u003eFolate carries the one-carbon units your cells need to build DNA and keep the methionine cycle turning.† Most supplements use folic acid, a fully oxidized form your body must first convert with an enzyme called DHFR; food folates are already in the reduced tetrahydrofolate form (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Folate-HealthProfessional\/\"\u003eNIH fact sheet on folate\u003c\/a\u003e). In liver tissue from six people, DHFR converted folic acid at less than 2% of the rate seen in rat liver, and activity varied almost fivefold between people (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19706381\/\"\u003eBailey and Ayling, 2009\u003c\/a\u003e). Folinate is a formyl form of tetrahydrofolate, the same reduced family as food folate, so it doesn't wait on DHFR. To be fair, that was a lab study, not a supplement trial, and the NIH puts folic acid absorption at about 85% with food. Folinate just takes one step out of the way.\u003c\/p\u003e\n\u003ch3\u003eVitamin B6 (4 mg from pyridoxine HCl): the protein-metabolism helper\u003c\/h3\u003e\n\u003cp\u003eYour body turns pyridoxine into pyridoxal 5' phosphate (PLP), the coenzyme form of B6, which takes part in more than 100 enzyme reactions, mostly in protein metabolism (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB6-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B6\u003c\/a\u003e).† One review names B6, B12 and folate as the B vitamins most involved in homocysteine metabolism, and describes the B group's roles in energy production, DNA synthesis and making the brain's chemical messengers (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003eKennedy, 2016\u003c\/a\u003e).† Pyridoxine HCl is the most common B6 form in supplements; if you want B6 already in coenzyme form, that's \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/p5p-50mg-vitamin-b6-supplement\"\u003eour P5P 50 mg\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eWhat the research does and doesn't show\u003c\/h3\u003e\n\u003cp\u003eWhat it shows: a pooled analysis of 25 randomized trials with 2,596 participants found folic acid reduced blood homocysteine by 13% to 25%, depending on dose; B12 (0.4 mg a day) brought it down about 7% more, and B6 had no significant effect (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16210710\/\"\u003eHomocysteine Lowering Trialists' Collaboration, 2005\u003c\/a\u003e). Those trials used folic acid, not folinate, and none tested this product.\u003c\/p\u003e\n\u003cp\u003eWhat it doesn't show: that B vitamins sharpen your thinking. A systematic review of 14 randomized trials found no clear effect of B6, B12 or folic acid on cognitive test scores, and most trials were small or low quality (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17210874\/\"\u003eBalk et al., 2007\u003c\/a\u003e). We haven't run a trial on B-12 Essential Trio itself; what we can show you is what's in each serving and how every lot is tested.\u003c\/p\u003e\n\u003ch2\u003eHow to take B-12 Essential Trio\u003c\/h2\u003e\n\u003cp\u003eThe label directions, word for word: \"Take one serving by mouth in the morning.\" One serving is a single squeeze of the dropper bulb, which fills about half the dropper.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSqueeze the bulb once, release, and drip the liquid into your mouth, or into a little water or juice.\u003c\/li\u003e\n\u003cli\u003eRefrigerate after opening, as the label says.\u003c\/li\u003e\n\u003cli\u003eAt one serving each morning, a bottle's 80 servings last 80 days.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. The label gives no serving for children, so check with your child's practitioner first. Acid-reducing medicines can make it harder to absorb B12 from food.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. Fifty-two years in, here's how we back up this label:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the methylcobalamin, folinate and B6 included, for identity, potency, heavy metals and microbes. Here's \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/our-approach-to-raw-material-sourcing-and-testing\"\u003ehow we source and test raw materials\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/b12-sublingual-essential-trio\"\u003eSee the certificates of analysis for this product\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e B-12 Essential Trio is made in our UL-certified cGMP facility in Mt. Angel, a farm town of about 3,500 in the Willamette Valley. The people who formulate, make and test it work under one roof, and the owners work in the building too. We're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much B12, folate and B6 is in one serving?\u003c\/h3\u003e\n\u003cp\u003eOne serving has 2,000 mcg of vitamin B12 as methylcobalamin (83,333% of the Daily Value), 680 mcg DFE of folate as folinate (170%) and 4 mg of vitamin B6 from pyridoxine HCl (235%).\u003c\/p\u003e\n\u003ch3\u003eIs B-12 Essential Trio a sublingual B12?\u003c\/h3\u003e\n\u003cp\u003eYou can take it that way; the label simply says to take one serving by mouth in the morning. Holding it under your tongue first is fine, though the NIH says evidence suggests no difference in efficacy between oral and sublingual B12.\u003c\/p\u003e\n\u003ch3\u003eIs 2,000 mcg of B12 too much?\u003c\/h3\u003e\n\u003cp\u003eIt's a large dose, but no upper limit has been set for vitamin B12 because of its low potential for toxicity, and you absorb only a small share of it. The 4 mg of B6 is well under the 100 mg adult upper limit. If you take medication, check with your practitioner first.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with B-Complex or Triple B-12 Dots?\u003c\/h3\u003e\n\u003cp\u003eCheck the totals first, because they overlap. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b-good-com-vitamin-b-complex\"\u003eOur B-Complex with all eight B vitamins\u003c\/a\u003e already has 100 mg of B6 per capsule, so adding B-12 Essential Trio brings B6 to 104 mg a day, just over the 100 mg adult upper limit. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-dots-energy-nervous-support\"\u003eTriple B-12 Dots\u003c\/a\u003e add 1,000 mcg of B12 per dot, which you likely don't need on top of 2,000 mcg. Most people pick one, or ask a practitioner first.\u003c\/p\u003e\n\u003ch3\u003eHow soon will I notice a difference?\u003c\/h3\u003e\n\u003cp\u003eThere's no jolt, because B vitamins aren't stimulants; they keep enzymes supplied. If your intake was already good, you may not feel a difference at all, and that's normal.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eFroese DS et al. Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDoets EL et al. Systematic review on daily vitamin B12 losses and bioavailability for deriving recommendations on vitamin B12 intake with the factorial approach. Ann Nutr Metab. 2013. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23796635\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBailey SW et al. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci U S A. 2009. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19706381\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHomocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16210710\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBalk EM et al. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch Intern Med. 2007. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17210874\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"1","offer_id":44364424479002,"sku":"015-M2210","price":25.99,"currency_code":"USD","in_stock":true},{"title":"3","offer_id":44900315201818,"sku":"015-M2210-3","price":69.99,"currency_code":"USD","in_stock":true},{"title":"5","offer_id":44900315234586,"sku":"015-M2210-5","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M2210_REV02_Box.png?v=1738258018"},{"product_id":"energy-focus-stack-adrenal-b12","title":"Energy \u0026 Focus Stack – Adrenal Support, B-12 Essential Trio \u0026 B-Complex","description":"\u003cp\u003e\u003cstrong\u003eThe Energy \u0026amp; Focus Stack is three bottles: Adrenal Support (an adaptogen blend plus vitamins B5, B6 and C; 60 vegetarian tablets), B-12 Essential Trio (2,000 mcg of methylcobalamin per serving; 2 fl oz liquid) and B-Complex (all eight B vitamins; 60 vegetarian capsules). Together they support normal energy metabolism and a healthy response to occasional stress.† The stack is $60.36, versus $81.97 bought separately, so you save $21.61 (about 26%).\u003c\/strong\u003e\u003c\/p\u003e\r\n\u003cp\u003eThis stack is for the years when the calendar is full and coffee is doing too much of the work: late 30s and 40s, a demanding job, kids or aging parents, a training plan you'd like to keep. Aging isn't optional. Getting old is. The habits you build now are the ones that carry you into your 70s and 80s.\u003c\/p\u003e\r\n\u003ch2\u003eAdrenal Support: adaptogen herbs plus vitamins B5, B6 and C\u003c\/h2\u003e\r\n\u003cp\u003eEach 2-tablet serving of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/adrenal-support-60-vegetarian\"\u003eAdrenal Support, our adaptogen tablet\u003c\/a\u003e has 50 mg of vitamin C (55% DV), 20 mg of vitamin B6 from pyridoxine HCl (1,176% DV) and 500 mg of pantothenic acid from d-calcium pantothenate (10,000% DV), plus a 425 mg proprietary herbal blend: rhodiola root extract (standardized to 1% salidrosides), ashwagandha root extract (standardized to 2.5% withanolides), wild yam root extract, schizandra berry, eleuthero root extract and organic stinging nettle leaf. The bottle holds 30 servings.\u003c\/p\u003e\r\n\u003cp\u003e\"Adaptogen\" is what researchers call herbs studied for helping the body hold its balance under stress. In one 60-day trial, 60 healthy adults who reported high stress took 240 mg of a standardized ashwagandha extract or a placebo daily. The ashwagandha group had a larger drop in morning cortisol, with no side effects reported (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ea 60-day ashwagandha trial in stressed, healthy adults\u003c\/a\u003e).† A systematic review of 11 placebo-controlled rhodiola trials found it may help physical and mental performance with few, mild side effects, though the authors noted that the individual trials hadn't been independently repeated (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21036578\/\"\u003ea systematic review of rhodiola trials\u003c\/a\u003e).† One honest note: the label doesn't list each herb's amount, so we can't say a serving matches those study doses.\u003c\/p\u003e\r\n\u003ch2\u003eB-12 Essential Trio: liquid methylcobalamin, folinate and B6\u003c\/h2\u003e\r\n\u003cp\u003eOne serving of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-sublingual-essential-trio\"\u003eB-12 Essential Trio, our liquid B12\u003c\/a\u003e is one dropper bulb squeeze (about half a dropper, about 0.84 grams): 2,000 mcg of vitamin B12 as methylcobalamin (83,333% DV), 680 mcg DFE of folinate from calcium folinate (170% DV) and 4 mg of vitamin B6 (235% DV). The 2 fl oz bottle holds 80 servings, with natural blueberry flavor.\u003c\/p\u003e\r\n\u003cp\u003eWhy these forms: methylcobalamin is one of the two forms of B12 your cells use directly; cyanocobalamin gets converted first (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e). Folinate is already in the reduced folate family, so it skips the conversion step folic acid needs. B12, folate and B6 work as a team in the cycle that supplies methyl groups to your cells.†\u003c\/p\u003e\r\n\u003ch2\u003eB-Complex: all eight B vitamins in one capsule\u003c\/h2\u003e\r\n\u003cp\u003eOne capsule of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b-good-com-vitamin-b-complex\"\u003eB-Complex, our one-a-day B vitamin capsule\u003c\/a\u003e has 100 mg each of thiamin, riboflavin, vitamin B6 and pantothenic acid, niacinamide (100 mg NE), 680 mcg DFE of folic acid, 100 mcg of vitamin B12 (cyanocobalamin) and 100 mcg of biotin, plus 47 mg of choline, 100 mg of inositol and 60 mg of PABA. The bottle holds 60 capsules, a 60-day supply at the label's one capsule a day.\u003c\/p\u003e\r\n\u003cp\u003eB vitamins don't supply calories. They're coenzymes, helpers your enzymes need to pull energy out of food and to make DNA and brain chemical messengers. A review of all eight shows how closely their jobs overlap, which is the author's case for taking the whole group (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003ea review of how the eight B vitamins work together\u003c\/a\u003e).†\u003c\/p\u003e\r\n\u003ch2\u003eHow to take them together\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eAdrenal Support:\u003c\/strong\u003e \"One to two tablets, as a dietary supplement.\" The amounts above are for 2 tablets.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eB-12 Essential Trio:\u003c\/strong\u003e \"Take one serving by mouth in the morning.\" Refrigerate after opening.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eB-Complex:\u003c\/strong\u003e \"One capsule daily, as a dietary supplement.\"\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003eMind the vitamin B6: at full label servings the three bottles add up to 124 mg a day (20 + 4 + 100), above the 100 mg daily upper limit for adults from food and supplements combined (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB6-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B6\u003c\/a\u003e). Check with your practitioner before taking all three at full servings. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\r\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e See the \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/b12-sublingual-essential-trio\"\u003ecertificates of analysis for B-12 Essential Trio\u003c\/a\u003e.\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and all three formulas are made and tested in our UL-certified cGMP facility there, with the formulators, the makers and the testers under one roof. The owners work in the building too; it's been owner-run since 2017. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\r\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\r\n\u003ch3\u003eDoes the Energy \u0026amp; Focus Stack contain caffeine?\u003c\/h3\u003e\r\n\u003cp\u003eNo. None of the three labels lists caffeine. The energy side of this stack comes from B vitamins, which help your body use the food you eat.†\u003c\/p\u003e\r\n\u003ch3\u003eWhy are there two kinds of B12 and folate?\u003c\/h3\u003e\r\n\u003cp\u003eEach bottle is built to stand on its own: the Trio uses methylcobalamin and folinate, and B-Complex uses cyanocobalamin and folic acid. Together that's 2,100 mcg of B12, and no upper limit has been set for B12 because of its low potential for toxicity (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e).\u003c\/p\u003e\r\n\u003ch3\u003eHow long does the stack last?\u003c\/h3\u003e\r\n\u003cp\u003eThe bottles run out at different times. Adrenal Support holds 30 servings of 2 tablets, B-12 Essential Trio holds 80 servings, and B-Complex is a 60-day supply at one capsule a day.\u003c\/p\u003e\r\n\u003ch3\u003eIs the stack safe with my medication?\u003c\/h3\u003e\r\n\u003cp\u003eAsk your healthcare practitioner, and bring all three bottles. Herbs aren't harmless just because they're plants. You can also check combinations in our \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/tools\/interaction-checker\"\u003esupplement and medication interaction checker\u003c\/a\u003e.\u003c\/p\u003e\r\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/single-bottle-solution-what-is-it-and-why-do-we-put-it-on-our-premium-bottles\"\u003eWhat \"Single Bottle Solution\" on our labels means\u003c\/a\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch2\u003eReferences\u003c\/h2\u003e\r\n\u003col\u003e\r\n\u003cli\u003eLopresti AL et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eHung SK et al. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21036578\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eKennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":50897017176346,"sku":"BundleM1000M2210A2207","price":60.36,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/Bundle_Group_Image.png?v=1753454087"},{"product_id":"cortiresponse-stress-mood-support","title":"CortiResponse – Daily Stress, Mood \u0026 Mental Clarity Support | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eCortiResponse is a 60-capsule formula for daily stress, mood and mental clarity support.† Each 2-capsule serving combines 100 mg of L-theanine, 100 mg of ashwagandha root, 180 mg of holy basil 10:1 extract, 100 mg of passionflower 4:1 extract and 300 mg of magnolia bark 4:1 extract with green tea, cocoa and 120 mcg of chromium. It's made to support a healthy response to occasional stress.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStress doesn't book an appointment. In your 30s and 40s it's deadlines, kids, aging parents and a phone that won't stop buzzing, and the habits you build now carry into the decades ahead. CortiResponse is one simple daily step for staying steady and clear-headed, alongside sleep, food and movement.† Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take CortiResponse\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eTo support a healthy cortisol response to occasional, everyday stress, with ashwagandha, holy basil and magnolia bark.†\u003c\/li\u003e\n\u003cli\u003eTo support calm, relaxed alertness, with 100 mg of L-theanine.†\u003c\/li\u003e\n\u003cli\u003eTo support a positive mood and ease occasional tension, with passionflower and magnolia bark.†\u003c\/li\u003e\n\u003cli\u003eTo support mental clarity and focus on demanding days.†\u003c\/li\u003e\n\u003cli\u003eTo support normal carbohydrate metabolism, with 120 mcg of chromium.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChromium (chromium polynicotinate, GTF)\u003c\/td\u003e\n\u003ctd\u003e120 mcg\u003c\/td\u003e\n\u003ctd\u003e342%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCocoa Seed Extract (\u003cem\u003eTheobroma cacao\u003c\/em\u003e) (standardized to 6% theobromine)\u003c\/td\u003e\n\u003ctd\u003e300 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnolia Bark 4:1 Extract (\u003cem\u003eMagnolia officinalis\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e300 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGreen Tea Leaf Extract (\u003cem\u003eCamilla sinensis\u003c\/em\u003e) (standardized to 50% polyphenols and 35% catechins)\u003c\/td\u003e\n\u003ctd\u003e200 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHoly Basil Herb 10:1 Extract (\u003cem\u003eOcimum sanctum\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e180 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAshwagandha Root (\u003cem\u003eWithania somnifera\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePassionflower Herb (\u003cem\u003ePassiflora incarnata\u003c\/em\u003e) 4:1 Extract\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eL-Theanine\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBanaba Leaf Standardized Extract (\u003cem\u003eLagerstroemia speciosa\u003c\/em\u003e) (standardized to 1% corosolic acid)\u003c\/td\u003e\n\u003ctd\u003e10 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e* Daily Value not established. Serving size: 2 vegetarian capsules. Servings per container: 30. Each bottle holds 60 capsules. Other ingredients: Cellulose (from capsule shell), cellulose, vegetable stearate, and silicon dioxide. The bottle's side panel carries Gluten-Free, Dairy-Free, Soy-Free and Made in the USA icons.\u003c\/p\u003e\n\u003ch2\u003eHow CortiResponse works\u003c\/h2\u003e\n\u003cp\u003eStress tells your adrenal glands to release cortisol through what researchers call the HPA (hypothalamic-pituitary-adrenal) axis. The goal is a response that rises when you need it and settles when you don't, and several ingredients below were studied for that.† Many studies used branded extracts, often at higher amounts than one serving.\u003c\/p\u003e\n\u003ch3\u003eL-theanine, 100 mg\u003c\/h3\u003e\n\u003cp\u003eL-theanine is an amino acid from tea leaves. In a crossover trial in healthy, moderately stressed adults, a single 200 mg dose produced a larger rise in alpha brain waves (the pattern linked with relaxed alertness) than placebo three hours later, and a larger drop in salivary cortisol at one hour (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34562208\/\"\u003ea single-dose L-theanine trial during a mental stress test\u003c\/a\u003e). In a four-week crossover trial, 30 healthy adults (average age 48) took 200 mg a day in one period and a placebo in another. Stress-symptom and sleep-quality scores improved during the L-theanine weeks (some sleep scores beat placebo outright), as did verbal fluency and executive function (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31623400\/\"\u003ea four-week L-theanine trial in healthy adults\u003c\/a\u003e). Both studies were small and used twice the amount in one serving.†\u003c\/p\u003e\n\u003ch3\u003eAshwagandha root, 100 mg\u003c\/h3\u003e\n\u003cp\u003eAshwagandha (\u003cem\u003eWithania somnifera\u003c\/em\u003e) is a root from Ayurvedic tradition and one of the most researched herbs scientists call adaptogens. In a 60-day trial, 60 healthy adults with high self-reported stress took 240 mg of a standardized extract or a placebo daily. The ashwagandha group had a larger drop in morning cortisol, with no side effects reported (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ea 60-day ashwagandha trial in stressed, healthy adults\u003c\/a\u003e). The candid part: CortiResponse has 100 mg of ashwagandha root, not a concentrated extract, so it plays a supporting role.†\u003c\/p\u003e\n\u003ch3\u003eHoly basil 10:1 extract, 180 mg\u003c\/h3\u003e\n\u003cp\u003eHoly basil, or tulsi (\u003cem\u003eOcimum sanctum\u003c\/em\u003e, also called \u003cem\u003eOcimum tenuiflorum\u003c\/em\u003e), is a cousin of kitchen basil. A 10:1 extract is concentrated from about 10 parts herb to 1 part extract. In an 8-week trial, 100 stressed adults aged 18 to 65 took 125 mg of a standardized holy basil extract twice a day or a placebo. The holy basil group saw bigger improvements in perceived stress and sleep-quality scores, lower hair cortisol at week 8, and lower salivary cortisol after a lab stress test (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36185698\/\"\u003ean 8-week holy basil trial in stressed adults\u003c\/a\u003e). That was a different extract than ours, so read it as evidence for the herb, not this capsule.†\u003c\/p\u003e\n\u003ch3\u003eMagnolia bark 4:1 extract, 300 mg\u003c\/h3\u003e\n\u003cp\u003eMagnolia bark (\u003cem\u003eMagnolia officinalis\u003c\/em\u003e) is a staple of traditional Chinese herbal practice. Most human research pairs it with a second bark, phellodendron. In a 4-week trial, 56 moderately stressed adults took that combination or a placebo. The combination group's salivary cortisol exposure was 18% lower than placebo, and their mood-state scores, including tension and fatigue, were better (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23924268\/\"\u003ea 4-week magnolia and phellodendron trial\u003c\/a\u003e). CortiResponse has no phellodendron, so that study speaks to the pairing, not magnolia alone.†\u003c\/p\u003e\n\u003ch3\u003ePassionflower 4:1 extract, 100 mg\u003c\/h3\u003e\n\u003cp\u003ePassionflower (\u003cem\u003ePassiflora incarnata\u003c\/em\u003e) is a climbing vine with a long folk history as a calming herb. The 100 mg of 4:1 extract comes from about 400 mg of the dried herb. Most human passionflower trials took place in medical settings, not everyday stress, so we don't cite them here.†\u003c\/p\u003e\n\u003ch3\u003eGreen tea leaf and cocoa seed extracts\u003c\/h3\u003e\n\u003cp\u003eThe green tea leaf extract (200 mg) is standardized to 50% polyphenols and 35% catechins, about 100 mg of polyphenols and 70 mg of catechins per serving. Catechins such as EGCG are green tea's best-known antioxidants. The cocoa seed extract (300 mg) is standardized to 6% theobromine, about 18 mg per serving. Theobromine is cocoa's gentler cousin of caffeine.†\u003c\/p\u003e\n\u003ch3\u003eChromium and banaba leaf\u003c\/h3\u003e\n\u003cp\u003eChromium is a trace mineral that might help insulin do its job, and it may play a role in carbohydrate, fat and protein metabolism (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Chromium-HealthProfessional\/\"\u003eNIH fact sheet on chromium\u003c\/a\u003e). Ours is chromium polynicotinate (chromium bound to niacin), sometimes labeled GTF. No upper limit has been set for chromium. Banaba leaf extract adds 10 mg. Most human banaba research involves people whose blood sugar is outside the normal range, so we don't cite it here.†\u003c\/p\u003e\n\u003ch2\u003eHow to take CortiResponse\u003c\/h2\u003e\n\u003cp\u003eThe label says: \"Take one to two capsules, 30 minutes before a meal, as a dietary supplement.\" The amounts in the table are for a 2-capsule serving.\u003c\/p\u003e\n\u003cp\u003eThe label warns: \"Not recommended while pregnant or lactating unless directed by a health care practitioner.\" Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. Ashwagandha has been well tolerated in trials lasting up to about three months, and its long-term safety isn't known (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Ashwagandha-HealthProfessional\/\"\u003eNIH fact sheet on ashwagandha\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of CortiResponse gets its own.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley. Our UL-certified cGMP facility keeps the formulators, the makers and the testers under one roof, and the owners (it's been owner-run since 2017) work in the building. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow many CortiResponse capsules should I take?\u003c\/h3\u003e\n\u003cp\u003eOne to two capsules, 30 minutes before a meal, per the label. The Supplement Facts amounts are for 2 capsules.\u003c\/p\u003e\n\u003ch3\u003eDoes CortiResponse contain caffeine?\u003c\/h3\u003e\n\u003cp\u003eThe label doesn't list caffeine. It does contain green tea leaf extract, which can carry some naturally occurring caffeine, and cocoa seed extract, which supplies about 18 mg of theobromine per serving. Sensitive to stimulants? Start with one capsule.\u003c\/p\u003e\n\u003ch3\u003eWill CortiResponse make me drowsy?\u003c\/h3\u003e\n\u003cp\u003eIt isn't made as a sleep formula: there's no melatonin on the label, and the L-theanine research focuses on calm alertness. The NIH lists mild drowsiness as a possible ashwagandha side effect, so notice how you feel at first.\u003c\/p\u003e\n\u003ch3\u003eHow long does it take to notice CortiResponse?\u003c\/h3\u003e\n\u003cp\u003eIt depends on the ingredient. The L-theanine trial measured changes within hours of one dose, while the ashwagandha and holy basil trials ran 60 days and 8 weeks.\u003c\/p\u003e\n\u003ch3\u003eCan I take CortiResponse with your other products?\u003c\/h3\u003e\n\u003cp\u003eYes, but check for shared ingredients first. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/relaxation-supplement-passion-fl\"\u003eRelaxing Passion Flower lozenges\u003c\/a\u003e (50 mg of passionflower 4:1 extract each) and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/natural-sleep-aid-herbal-support\"\u003eSleepy Sleep\u003c\/a\u003e both contain passionflower. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/adrenal-support-60-vegetarian\"\u003eAdrenal Support\u003c\/a\u003e also has ashwagandha, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/good-magnesium-chelate-amino-acids\"\u003eGood Magnesium\u003c\/a\u003e lists holy basil in its other ingredients, and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/brain-advantage\"\u003eBrain Advantage\u003c\/a\u003e has 30 mg of L-theanine. If you stack, run the combination by your practitioner.\u003c\/p\u003e\n\u003ch3\u003eCan I take CortiResponse with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first. Per the NIH fact sheets, ashwagandha might interact with thyroid hormone, blood sugar, blood pressure, immune-suppressing and sedative medications, and chromium might add to the effect of blood sugar medications or reduce levothyroxine absorption.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/single-bottle-solution-what-is-it-and-why-do-we-put-it-on-our-premium-bottles\"\u003eWhat \"Single Bottle Solution\" on our labels means\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eEvans M et al. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population. Neurology and Therapy. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34562208\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHidese S et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31623400\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLopresti AL et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLopresti AL et al. A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer™) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36185698\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eTalbott SM et al. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition. 2013. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23924268\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":50951720304922,"sku":"015-A6001","price":33.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/A6001_REV00_NewItemBadge.png?v=1755025348"},{"product_id":"brain-advantage","title":"Brain Advantage – Brain Energy, Focus \u0026 Recall Support | 60 Vegetarian Capsules","description":"\u003cp\u003e\u003cstrong\u003eBrain Advantage is a two-capsule daily nootropic with 250 mg of Cognizin® citicoline, 320 mg of Synapsa™ bacopa extract standardized to 55% bacosides, and 500 mg of lion's mane extract, plus ginkgo, L-theanine, methylfolate, niacinamide, vitamin C, magnesium and zinc. Each bottle holds 60 vegetarian capsules, a 30-day supply. It supports brain energy, mental focus and recall.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBrain Advantage is for people who would like their memory to keep up with their calendar. Maybe you're 42 and juggling a team and a household. Maybe you're 60 and have big plans for your 80s. Either way, the time to look after your brain is before you're worried about it, which for most people means starting in your 30s and 40s. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003cp\u003eThere's no caffeine in it and nothing designed to give you a buzz. Citicoline and bacopa, the two headline ingredients, both have placebo-controlled research in healthy adults, and both are here as named, branded ingredients with every amount printed. No proprietary blend, no guessing.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Brain Advantage\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBrain energy.\u003c\/strong\u003e Citicoline supplies choline and cytidine, raw materials brain cells use to build their membranes, and it is studied for its role in brain energy metabolism.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFocus and attention.\u003c\/strong\u003e Brain Advantage supports mental focus, and bacopa supports attention and processing speed with consistent daily use.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMemory and recall.\u003c\/strong\u003e Bacopa supports learning and the retention of newly learned information with steady daily use.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEveryday nutrient support.\u003c\/strong\u003e Folate as L-5-methyltetrahydrofolate supports normal methylation, and niacinamide (vitamin B3) supports normal energy metabolism.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin C (from Magnesium and Zinc Ascorbate)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e111%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNiacinamide\u003c\/td\u003e\n\u003ctd\u003e122 mg\u003c\/td\u003e\n\u003ctd\u003e766%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFolate (from L-5-Methyltetrahydrofolate, LMTHF)\u003c\/td\u003e\n\u003ctd\u003e400 mcg DFE\u003c\/td\u003e\n\u003ctd\u003e100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium (from magnesium ascorbate)\u003c\/td\u003e\n\u003ctd\u003e22 mg\u003c\/td\u003e\n\u003ctd\u003e5%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (from zinc ascorbate)\u003c\/td\u003e\n\u003ctd\u003e11 mg\u003c\/td\u003e\n\u003ctd\u003e100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLion's Mane Extract (from \u003cem\u003eHercicium erinaceus\u003c\/em\u003e mushroom)\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eBacopa monnieri\u003c\/em\u003e whole plant extract (from Synapsa™, standardized to 55% Bacosides)\u003c\/td\u003e\n\u003ctd\u003e320 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCiticoline (from Cognizin®)\u003c\/td\u003e\n\u003ctd\u003e250 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eGinkgo biloba\u003c\/em\u003e Leaf Extract (contains 24% ginkgoflavonglycosides and 6% terpene lactones)\u003c\/td\u003e\n\u003ctd\u003e60 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eL-Theanine\u003c\/td\u003e\n\u003ctd\u003e30 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 2 Vegetarian Capsules. Servings per container: 30. Other ingredients: Vegetable Cellulose (from capsule shell), Organic Rice Extract, Silica, and Organic Rice Concentrate. The front label carries gluten-free, dairy-free and soy-free icons.\u003c\/p\u003e\n\u003ch2\u003eHow Brain Advantage works\u003c\/h2\u003e\n\u003ch3\u003eCognizin® citicoline (250 mg)\u003c\/h3\u003e\n\u003cp\u003eCiticoline, also called CDP-choline, is a compound your body already makes from two parts, choline and cytidine. Brain cells use them to build phosphatidylcholine, a main ingredient in cell membranes, and choline is also the raw material for acetylcholine, a messenger that attention and memory circuits rely on.† Cognizin, from Kyowa Hakko Bio, is the citicoline used in both studies below.\u003c\/p\u003e\n\u003cp\u003eIn a small 6-week study with no placebo group, 16 healthy adults (average age 47) took 500 mg or 2,000 mg of Cognizin a day, and brain scans showed higher energy reserves in the frontal lobe, including a 14% rise in a measure that mostly reflects ATP, the molecule cells spend as energy (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18816480\/\"\u003eSilveri et al., 2008\u003c\/a\u003e). In a 12-week placebo-controlled trial of 100 healthy adults aged 50 to 85 with mild, age-related memory changes, the 49 who took 500 mg a day improved more than the placebo group on episodic memory (remembering pairs of items) and an overall memory score (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33978188\/\"\u003eNakazaki et al., 2021\u003c\/a\u003e). Fair warning: those were secondary outcomes, scientists from Cognizin's maker were among the authors, and 500 mg is twice the amount in a serving here.\u003c\/p\u003e\n\u003ch3\u003eSynapsa™ bacopa (320 mg)\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eBacopa monnieri\u003c\/em\u003e is a creeping wetland herb with a long history in Ayurvedic tradition. Its active compounds, the bacosides, vary a lot from one extract to another, which is why this label states the standardization: 55% bacosides. Synapsa is the U.S. name for the extract sold in Australia as KeenMind.\u003c\/p\u003e\n\u003cp\u003eBacopa is a slow worker. In a 12-week placebo-controlled trial in healthy adults, 300 mg a day of KeenMind improved speed of visual information processing, learning rate and memory consolidation (how well newly learned information sticks), with the largest effects at week 12 rather than week 5 (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11498727\/\"\u003eStough et al., 2001\u003c\/a\u003e). A meta-analysis of nine placebo-controlled trials with 518 participants, testing standardized bacopa extracts for 12 weeks or more, found faster times on two attention and reaction-time tests (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24252493\/\"\u003eKongkeaw et al., 2014\u003c\/a\u003e). The differences were measured in milliseconds: statistically clear, but small.\u003c\/p\u003e\n\u003ch3\u003eLion's mane mushroom extract (500 mg)\u003c\/h3\u003e\n\u003cp\u003eLion's mane (\u003cem\u003eHericium erinaceus\u003c\/em\u003e) is an edible mushroom that looks like a shaggy white pom-pom, and its human research is early. In a pilot trial of 41 healthy adults aged 18 to 45, a single 1.8 g dose made people faster on one attention test an hour later, 28 days of use brought a trend toward lower self-reported stress that just missed statistical significance, and several other measures didn't change (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38004235\/\"\u003eDocherty et al., 2023\u003c\/a\u003e). That's more than three times the 500 mg here, so lion's mane is a supporting ingredient, not the reason to buy.\u003c\/p\u003e\n\u003ch3\u003eGinkgo biloba (60 mg) and L-theanine (30 mg)\u003c\/h3\u003e\n\u003cp\u003eThe ginkgo leaf extract is standardized to 24% ginkgoflavonglycosides and 6% terpene lactones, as the label states. L-theanine is an amino acid found in tea leaves. Both are here in supporting amounts, and we don't ask them to carry the formula.\u003c\/p\u003e\n\u003ch3\u003eThe vitamins and minerals\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eFolate (400 mcg DFE)\u003c\/strong\u003e comes as L-5-methyltetrahydrofolate, the form your body already uses, so there's no conversion step from folic acid. It supports normal methylation, a basic chemical process your cells run every day.† \u003cstrong\u003eNiacinamide (122 mg)\u003c\/strong\u003e is a form of vitamin B3 that your cells use to make NAD+, a coenzyme involved in turning food into energy,† and it doesn't cause the skin flushing that nicotinic acid can (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Niacin-HealthProfessional\/\"\u003eNIH niacin fact sheet\u003c\/a\u003e). \u003cstrong\u003eVitamin C (100 mg), magnesium (22 mg) and zinc (11 mg)\u003c\/strong\u003e arrive together as magnesium and zinc ascorbate, so the minerals come bound to the vitamin C. Vitamin C supports the body's normal antioxidant defenses, and many of your enzymes depend on zinc.†\u003c\/p\u003e\n\u003ch2\u003eHow to take Brain Advantage\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDirections on the label:\u003c\/strong\u003e \"Take two capsules daily, as a dietary supplement.\"\u003c\/p\u003e\n\u003cp\u003eTwo capsules is one serving, so a bottle lasts 30 days. Give it time: the 12-week bacopa and citicoline trials above measured results after three months of daily use.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. That goes double if you take a blood thinner or thyroid medication, since Brain Advantage contains ginkgo and bacopa.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. Fifty-two years in, we know a nice adjective isn't proof. Here's what is.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the citicoline and bacopa included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of Brain Advantage gets its own.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon, with globally sourced ingredients.\u003c\/strong\u003e Brain Advantage is formulated, made and tested in our UL-certified cGMP facility in Mt. Angel, a farm town of about 3,500 people in the Willamette Valley. Our formulators, makers and testers work under one roof, and the owners work in the building too. Owner-run since 2017, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow long does Brain Advantage take to work?\u003c\/h3\u003e\n\u003cp\u003ePlan on about 12 weeks of daily use before you judge it. In a placebo-controlled trial, bacopa's effects were largest at 12 weeks, and the citicoline memory trial also ran 12 weeks. Brain Advantage isn't a stimulant, so don't expect a jolt on day one.\u003c\/p\u003e\n\u003ch3\u003eDoes Brain Advantage have caffeine?\u003c\/h3\u003e\n\u003cp\u003eNo. There's no caffeine or other stimulant on the Supplement Facts panel, so you can keep your usual coffee or tea.\u003c\/p\u003e\n\u003ch3\u003eCan I take Brain Advantage with a multivitamin or CortiResponse?\u003c\/h3\u003e\n\u003cp\u003eUsually, yes, but add up the overlaps. Brain Advantage already gives you 122 mg of niacinamide, 400 mcg DFE of folate and 11 mg of zinc, so if you also take a multivitamin like our \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mens-multi-vitamin-60-capsules\"\u003eMen's Multi\u003c\/a\u003e or \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/womens-multi-cap-60ct\"\u003eWomen's Multi\u003c\/a\u003e, or a B-complex, check the totals on both labels. CortiResponse also contains L-theanine. If you take medication or aren't sure about a combination, ask your practitioner.\u003c\/p\u003e\n\u003ch3\u003eWhat makes Cognizin and Synapsa different from generic citicoline and bacopa?\u003c\/h3\u003e\n\u003cp\u003eThey're named, standardized ingredients you can trace to specific research: Cognizin is the citicoline in both citicoline studies above, and Synapsa is the U.S. name for the bacopa extract in the 12-week trial. A label that just says \"bacopa extract\" doesn't tell you which extract you're getting.\u003c\/p\u003e\n\u003ch3\u003eIs Brain Advantage safe to take with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first, and bring the bottle. Ginkgo and bacopa are the two ingredients worth naming, especially with a blood thinner or thyroid medication.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/bacopa-monnieri\"\u003eWhat the bacopa research does and doesn't show, trial by trial\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness, our formula for cellular energy and healthy NAD+ levels\u003c\/a\u003e†\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/cortiresponse-stress-mood-support\"\u003eCortiResponse, our ashwagandha and L-theanine formula for everyday stress\u003c\/a\u003e†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSilveri MM et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR in Biomedicine. 2008. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18816480\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eNakazaki E et al. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. The Journal of Nutrition. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33978188\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eStough C et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology. 2001. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11498727\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKongkeaw C et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of Ethnopharmacology. 2014. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24252493\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDocherty S et al. The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. 2023. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38004235\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":50978625356058,"sku":"015-M1005","price":61.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M1005_REV01_New_Item_Badge.png?v=1755624483"}],"url":"https:\/\/www.mtangelvitamins.com\/collections\/brain-focus-supplements.oembed","provider":"Mt. Angel Vitamins","version":"1.0","type":"link"}