{"title":"Energy \u0026 Cellular Health Supplements","description":"\u003cp\u003eFor everyday energy, start with the B vitamins your body uses to turn food into energy: B-12 Essential Trio or B-Complex Complete.† For cellular energy, Urolithin A 500 mg supports mitochondrial renewal, NMN + NR supports healthy NAD+ levels, and CoQ10 + ALA supports heart and cellular energy.†\u003c\/p\u003e","products":[{"product_id":"b12-dots-energy-nervous-support","title":"Triple B-12 Dots 1,000 mcg – Energy \u0026 Nervous System Support | 60 Dots","description":"\u003cp\u003e\u003cstrong\u003eTriple B-12 Dots are a cyanocobalamin-free vitamin B12 supplement. Each small dot provides 1,000 mcg of vitamin B12 (41,666% of the Daily Value) from three forms: 500 mcg hydroxycobalamin, 400 mcg adenosylcobalamin and 100 mcg methylcobalamin. You let one dissolve in your mouth, and each bottle holds 60 dots. Vitamin B12 supports normal energy production and a healthy nervous system.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePeople reach for B12 when they think about energy, and there's real biology behind that: your cells can't run two key energy and methylation reactions without it.† It matters most when intake or absorption runs low. B12 occurs naturally only in animal foods, so anyone eating little or no meat, fish, eggs or dairy needs another source. And the NIH advises adults over 50 to get most of their B12 from fortified foods or supplements, because many older adults don't make enough stomach acid to free B12 from food (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-Consumer\/\"\u003ethe NIH's consumer guide to vitamin B12\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003eIf you're in your 30s or 40s and building habits now so you can still hike, lift and keep up at 75, a daily B12 dot is one of the easiest to start. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Triple B-12 Dots\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports normal energy production, as the coenzyme your mitochondria need to turn parts of protein breakdown into fuel for the energy cycle.†\u003c\/li\u003e\n\u003cli\u003eSupports healthy nervous system function.†\u003c\/li\u003e\n\u003cli\u003eSupports normal red blood cell formation and DNA synthesis.†\u003c\/li\u003e\n\u003cli\u003eSupports healthy homocysteine metabolism by helping recycle homocysteine back into methionine, working alongside folate.†\u003c\/li\u003e\n\u003cli\u003eHelps maintain healthy B12 levels for people who eat few animal foods and for adults over 50.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B12 (500 mcg hydroxycobalamin, 400 mcg adenosylcobalamin (dibencozide), and 100 mcg methylcobalamin)\u003c\/td\u003e\n\u003ctd\u003e1,000 mcg\u003c\/td\u003e\n\u003ctd\u003e41,666%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 1 Dot. The panel doesn't print a servings-per-container line; the bottle holds 60 dots, which is 60 servings at the one-dot serving size. Other ingredients: Maltodextrin, acacia, cellulose, orange juice, magnesium stearate, and natural cinnamon flavor. The label states: \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\" It also states: \"Does not contain cyanocobalamin.\"\u003c\/p\u003e\n\u003ch2\u003eHow Triple B-12 Dots work\u003c\/h2\u003e\n\u003ch3\u003eVitamin B12 is a coenzyme, not a stimulant\u003c\/h3\u003e\n\u003cp\u003eB12 doesn't work like coffee. It's a helper molecule two specific enzymes can't run without. Your body uses two working forms, methylcobalamin and adenosylcobalamin, and converts other forms (like hydroxycobalamin) into those two (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e). Triple B-12 Dots give you both working forms ready-made, plus hydroxycobalamin, with no cyanocobalamin.\u003c\/p\u003e\n\u003ch3\u003eAdenosylcobalamin (400 mcg): the mitochondrial form\u003c\/h3\u003e\n\u003cp\u003eAdenosylcobalamin (dibencozide is another name for it) works inside your mitochondria, the parts of your cells that make most of your energy. There it helps an enzyme called methylmalonyl-CoA mutase convert leftovers from breaking down certain amino acids into a compound that feeds straight into the energy cycle (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\"\u003eFroese et al., 2019\u003c\/a\u003e). In plain terms, it keeps part of your protein metabolism flowing into fuel.†\u003c\/p\u003e\n\u003ch3\u003eMethylcobalamin (100 mcg): the methylation form\u003c\/h3\u003e\n\u003cp\u003eMethylcobalamin works in the main body of the cell with an enzyme called methionine synthase. That enzyme recycles homocysteine into methionine, which your body then uses to make SAMe, its most important methyl donor. The same step takes a methyl group from folate, which keeps folate moving through the cycle your cells use to build DNA (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\"\u003eFroese et al., 2019\u003c\/a\u003e). That's why B12 and folate are usually talked about as a team.† A review of B vitamins and the brain lists these same jobs (energy production, DNA synthesis and methylation) among the ways B vitamins support normal brain function (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003eKennedy, 2016\u003c\/a\u003e).†\u003c\/p\u003e\n\u003ch3\u003eHydroxycobalamin (500 mcg): the form your cells convert\u003c\/h3\u003e\n\u003cp\u003eHydroxycobalamin (often spelled hydroxocobalamin) makes up half of the B12 in each dot: 500 of the 1,000 mcg. Your cells convert it into either working form, so it can feed both the mitochondrial job and the methylation job (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e).†\u003c\/p\u003e\n\u003ch3\u003eWhy 1,000 mcg when the Daily Value is 2.4 mcg\u003c\/h3\u003e\n\u003cp\u003eBecause you absorb only a small share of a large dose. Your gut's main B12 absorption system fills up at about 1 to 2 mcg at a time, and the NIH puts absorption at about 1.3% of a 1,000 mcg dose: roughly 13 mcg per dot, still more than five times the 2.4 mcg Daily Value (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e). A systematic review of absorption studies found the same pattern with food: absorption ranged from 83% of a 3 mcg dose (from mutton) down to 4.5% of a 38 mcg dose (from liver) (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23796635\/\"\u003eDoets et al., 2013\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eWhat the research does and doesn't show\u003c\/h3\u003e\n\u003cp\u003eIt shows that intake matters. In 299 healthy adults aged 18 to 50, blood markers of B12 status leveled off once dietary intake reached about 4 to 7 mcg a day, above the 2.4 mcg Daily Value (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20071646\/\"\u003eBor et al., 2010\u003c\/a\u003e). In 2,999 adults from the Framingham Offspring Study, 8% of supplement users had blood B12 below 185 pmol\/L, compared with 20% of people who didn't take supplements; that's an observational snapshot, not a trial (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10648266\/\"\u003eTucker et al., 2000\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003eIt doesn't show that B12 supplements sharpen your thinking. A systematic review of 14 randomized trials found no clear effect of B6, B12 or folic acid supplements on cognitive test scores, and the authors rated most of those trials as low quality (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17210874\/\"\u003eBalk et al., 2007\u003c\/a\u003e). And to be straight with you, none of the studies above tested this three-form blend itself. What we can tell you is exactly what's in each dot and how each form is used.\u003c\/p\u003e\n\u003ch2\u003eHow to take Triple B-12 Dots\u003c\/h2\u003e\n\u003cp\u003eThe label directions, word for word: \"One or more dots daily, as a dietary supplement. For best absorption allow dot to dissolve in mouth completely.\"\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLet the dot dissolve fully in your mouth instead of swallowing it whole.\u003c\/li\u003e\n\u003cli\u003eThe label doesn't call for food, so pick whatever time of day you'll remember.\u003c\/li\u003e\n\u003cli\u003eOne dot is the label's serving. Not sure whether you need more? Ask your healthcare practitioner.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. Some common medications, including acid-reducing medicines, can lower B12 levels over time.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. Fifty-two years in, here's how we back up what's on this label:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the B12 included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of Triple B-12 Dots gets its own certificate of analysis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e Triple B-12 Dots are made in our UL-certified cGMP facility in Mt. Angel, a farm town of about 3,500 in the Willamette Valley. The people who formulate, make and test them work under one roof, and the owners work in the building too. We're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much vitamin B12 is in each dot?\u003c\/h3\u003e\n\u003cp\u003eEach dot has 1,000 mcg of vitamin B12, which is 41,666% of the Daily Value. It comes from 500 mcg hydroxycobalamin, 400 mcg adenosylcobalamin and 100 mcg methylcobalamin.\u003c\/p\u003e\n\u003ch3\u003eIs 1,000 mcg of B12 too much?\u003c\/h3\u003e\n\u003cp\u003eNo upper limit has been set for vitamin B12; the Food and Nutrition Board didn't establish one because of B12's low potential for toxicity. If you take medication or have a medical condition, check with your healthcare practitioner first.\u003c\/p\u003e\n\u003ch3\u003eWhy are the dots cyanocobalamin-free?\u003c\/h3\u003e\n\u003cp\u003eBecause we chose the two forms your cells actually work with, plus hydroxycobalamin, which cells convert into both. Your body converts cyanocobalamin into the working forms too, so this is a formulation choice, not a knock on other forms.\u003c\/p\u003e\n\u003ch3\u003eHow long until I notice anything?\u003c\/h3\u003e\n\u003cp\u003eThere's no set timeline, and you shouldn't expect a jolt, because B12 isn't a stimulant. It works as a helper in everyday cell reactions, so if your intake was already good you may not feel a difference at all. That's normal.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with B-12 Essential Trio or B-Complex?\u003c\/h3\u003e\n\u003cp\u003eYou can, but both already contain B12, so check the totals first. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-sublingual-essential-trio\"\u003eB-12 Essential Trio liquid with folinate and B6\u003c\/a\u003e has 2,000 mcg of methylcobalamin per serving, and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b-good-com-vitamin-b-complex\"\u003eour B-Complex with all eight B vitamins\u003c\/a\u003e has 100 mcg of vitamin B12 per capsule. If you want to combine them, ask your healthcare practitioner.\u003c\/p\u003e\n\u003ch3\u003eAre Triple B-12 Dots vegan?\u003c\/h3\u003e\n\u003cp\u003eThe label doesn't make a vegan claim. It does state \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives,\" and the other ingredients are listed in full above so you can decide for yourself.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/p5p-50mg-vitamin-b6-supplement\"\u003eP5P 50 mg, the coenzyme form of vitamin B6\u003c\/a\u003e, another B vitamin involved in homocysteine metabolism.†\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/everyday-liquid-sunshine-2-d3-k2\"\u003eEveryday Liquid Sunshine 2 vitamin D3 and K2 drops\u003c\/a\u003e, if you're building a simple daily foundation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eFroese DS et al. Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDoets EL et al. Systematic review on daily vitamin B12 losses and bioavailability for deriving recommendations on vitamin B12 intake with the factorial approach. Ann Nutr Metab. 2013. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23796635\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBor MV et al. Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population. Am J Clin Nutr. 2010. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20071646\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eTucker KL et al. Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study. Am J Clin Nutr. 2000. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10648266\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBalk EM et al. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch Intern Med. 2007. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17210874\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":44364426019098,"sku":"015-A2200","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/A2200_REV00_Necktag.png?v=1746812407"},{"product_id":"coq10-alpha-lipoic-acid","title":"CoQ10 100 mg Plus Alpha Lipoic Acid – Heart \u0026 Energy Support | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eCoQ10 Plus Alpha Lipoic Acid is a once-a-day vegetarian capsule with 100 mg of CoQ10 (coenzyme Q10), 100 mg of lecithin (from soybean) and 5 mg of alpha lipoic acid. Each bottle holds 60 capsules, a 60-day supply at the label's serving of one capsule. CoQ10 helps your mitochondria turn food into usable energy and supports healthy heart function.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYour body makes its own CoQ10, and the amount in most of your organs tends to peak in early adulthood and drift down from there. So this capsule is built for people in their late 30s and 40s who are already paying attention to energy and heart function, and for anyone over 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take CoQ10 Plus Alpha Lipoic Acid\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular energy.\u003c\/strong\u003e CoQ10 carries electrons inside your mitochondria, a step your cells need to make ATP, the energy they run on.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealthy heart function.\u003c\/strong\u003e Your heart beats around the clock on energy made by its mitochondria, and CoQ10 is part of that machinery.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant support.\u003c\/strong\u003e CoQ10 and alpha lipoic acid both take part in the body's normal defenses against everyday oxidative stress.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeeping up your CoQ10.\u003c\/strong\u003e Organ levels of CoQ10 tend to decline after early adulthood, and a daily supplement raises the CoQ10 in your blood.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCoQ10 (Coenzyme Q10)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLecithin (from soybean)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAlpha Lipoic Acid\u003c\/td\u003e\n\u003ctd\u003e5 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*Daily Value not established, as printed on the label. Serving size: 1 Vegetarian Capsule. Count: 60 vegetarian capsules, a 60-day supply at the label's serving. Other ingredients: Deep mined calcium phosphates, cellulose, vegetable cellulose (preservative-free, from capsule shell), magnesium trisilicate, silica, magnesium carbonate, \u0026amp; magnesium stearate. The label states: \"Uniquely formulated and emulsified to enhance the absorption of CoQ10.\" It also states: \"NO salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\" Allergen statement: \"Contains soy, from lecithin.\"\u003c\/p\u003e\n\u003ch2\u003eHow CoQ10 Plus Alpha Lipoic Acid works\u003c\/h2\u003e\n\u003ch3\u003eCoQ10 (coenzyme Q10), 100 mg\u003c\/h3\u003e\n\u003cp\u003eCoQ10 is a fat-soluble, vitamin-like compound your body makes on its own. It sits in the inner membrane of your mitochondria and shuttles electrons between the protein complexes that produce ATP. In its reduced form it also acts as an antioxidant within cell membranes.†\u003c\/p\u003e\n\u003cp\u003eYour own supply changes with age. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2779364\/\"\u003ea study of organ samples from people aged one day to 81 years\u003c\/a\u003e, researchers in Sweden found that CoQ10 (ubiquinone) in the heart, lungs, liver, kidneys and spleen peaked around age 20 and then kept decreasing. It was a measurement study, not a supplement trial, and it's part of why we say start in your 30s and 40s.\u003c\/p\u003e\n\u003cp\u003eDoes a supplement actually get in? In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18318910\/\"\u003ea 14-day trial in 41 healthy trained and untrained adults\u003c\/a\u003e, 100 mg of CoQ10 twice a day significantly raised blood CoQ10. Time to exhaustion on a treadmill test trended longer but didn't reach statistical significance, and oxidative stress markers after a single dose moved in mixed directions. So CoQ10 clearly reached the blood, while performance changes in this healthy, mostly young group were small and uncertain. The daily dose was also twice what one of our capsules holds.\u003c\/p\u003e\n\u003ch3\u003eLecithin (from soybean), 100 mg\u003c\/h3\u003e\n\u003cp\u003eCoQ10 is a large, oily molecule, and your gut absorbs it slowly and only in part. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16551570\/\"\u003eA review of how CoQ10 is absorbed and used\u003c\/a\u003e, written by researchers at a CoQ10 supplement maker, reports that solubilized CoQ10 formulations show better absorption, that blood levels peak about 6 hours after a dose, and that the half-life is about 33 hours. That long half-life is one reason a once-a-day capsule makes sense.\u003c\/p\u003e\n\u003cp\u003eLecithin is a mix of phospholipids, the same family of fats that forms your cell membranes, and it works as an emulsifier, helping oil and water mix. That's what the label means by \"emulsified to enhance the absorption of CoQ10.\" We haven't published an absorption study of this exact capsule, so read that as design reasoning, not a measured result. Because the lecithin comes from soybeans, this formula contains soy.\u003c\/p\u003e\n\u003ch3\u003eAlpha lipoic acid (ALA), 5 mg\u003c\/h3\u003e\n\u003cp\u003eAlpha lipoic acid is a sulfur-containing compound your body makes in small amounts. Inside mitochondria it's a working part of the enzymes that break down fuel from food, so it shares a workplace with CoQ10.† \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7649494\/\"\u003eA review of lipoic acid's antioxidant chemistry\u003c\/a\u003e describes how ALA and its reduced form react with several kinds of reactive oxygen species and interact with vitamin C and glutathione, which in turn can help recycle vitamin E. The same review notes the reduced form may also act as a pro-oxidant by reducing iron, a reminder that antioxidant chemistry has two sides.\u003c\/p\u003e\n\u003cp\u003eAbout the dose: 5 mg is a small, supporting amount, and the human research we found used far more. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15327583\/\"\u003ea placebo-controlled crossover study in 16 healthy men\u003c\/a\u003e (average age 58), a single 600 mg dose showed up in the blood but didn't change measures of oxidative stress or blood vessel function over the next 90 minutes. So think of the ALA here as a companion to the CoQ10, not a standalone ALA dose. We don't claim a measurable effect from the ALA on its own.\u003c\/p\u003e\n\u003ch3\u003eWhat the research does and doesn't show\u003c\/h3\u003e\n\u003cp\u003eWe know of no published trial of this exact formula; the studies above test CoQ10 or ALA separately, over hours to weeks. They support that CoQ10 is part of how your cells make energy, that organ levels decline after early adulthood, and that supplements raise blood levels.† They don't promise you'll feel a specific difference by a specific date.\u003c\/p\u003e\n\u003ch2\u003eHow to take CoQ10 Plus Alpha Lipoic Acid\u003c\/h2\u003e\n\u003cp\u003eDirections from the label: One capsule daily, as a dietary supplement.\u003c\/p\u003e\n\u003cp\u003eThe label doesn't set a time of day or say whether to take it with food. CoQ10 is fat-soluble, so many people take it with a meal that has some fat in it.\u003c\/p\u003e\n\u003cp\u003eIf you also take another of our formulas that contains CoQ10 (see the FAQ below), add up your daily total. For context, \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19096117\/\"\u003ea safety review of CoQ10\u003c\/a\u003e, written by researchers at a CoQ10 ingredient maker, put the observed safe level from human trials at 1,200 mg a day.\u003c\/p\u003e\n\u003cp\u003eAllergen statement from the label: Contains soy, from lecithin. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, CoQ10 and ALA included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Each one records what that lot was tested for and what the results were.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and our UL-certified cGMP facility is right there in it. The people who formulate this capsule, make it and test it all work under one roof, and the owners work in the building too (owner-run since 2017). We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much CoQ10 is in each capsule?\u003c\/h3\u003e\n\u003cp\u003eEach capsule has 100 mg of CoQ10, along with 100 mg of lecithin (from soybean) and 5 mg of alpha lipoic acid. One capsule is the full serving, so a 60-capsule bottle lasts 60 days at the label's directions.\u003c\/p\u003e\n\u003ch3\u003eWhen should I take it, and with food or without?\u003c\/h3\u003e\n\u003cp\u003eTake one capsule a day at whatever time you'll remember, since the label doesn't set one. Because CoQ10 is fat-soluble, many people take it with a meal that includes some fat.\u003c\/p\u003e\n\u003ch3\u003eHow long before I notice anything?\u003c\/h3\u003e\n\u003cp\u003eThere's no set timeline. In one trial in healthy adults, blood CoQ10 rose significantly within two weeks at 200 mg a day, but a blood level isn't the same as a difference you can feel, and people vary.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with YourHeart Nutrients or one of your multivitamins?\u003c\/h3\u003e\n\u003cp\u003eYou can, but count the CoQ10 in each. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/yourheart-nutrients-heart-health\"\u003eYourHeart Nutrients\u003c\/a\u003e has 100 mg of CoQ10 per 4-capsule serving, the \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mens-50-plus-multivitamin\"\u003eMen's 50+ Multivitamin\u003c\/a\u003e and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/womens-50-plus-multivitamin\"\u003eWomen's 50+ Multivitamin\u003c\/a\u003e each have 100 mg per 2-capsule serving, and the \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mens-multi-vitamin-60-capsules\"\u003eMen's Multi\u003c\/a\u003e has 50 mg per 2-capsule serving. Paired with this capsule, that's 150 to 200 mg a day, well under the 1,200 mg observed safe level in the safety review above. If you take medication, check with your practitioner first.\u003c\/p\u003e\n\u003ch3\u003eDoes it contain soy?\u003c\/h3\u003e\n\u003cp\u003eYes. The label says \"Contains soy, from lecithin.\" If you avoid soy, this formula isn't the right fit.\u003c\/p\u003e\n\u003ch3\u003eWill taking CoQ10 make my body stop making its own?\u003c\/h3\u003e\n\u003cp\u003eAccording to the safety review cited above, no. It concluded that supplemental CoQ10 doesn't appear to change the body's own CoQ10 production and doesn't build up in blood or tissue after you stop taking it.\u003c\/p\u003e\n\u003ch3\u003eIs it safe to take with my medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner before you start. Bring the bottle so they can read the full label.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A 500 mg\u003c\/a\u003e, one capsule a day, which supports mitochondrial renewal and cellular energy.†\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/single-bottle-solution-what-is-it-and-why-do-we-put-it-on-our-premium-bottles\"\u003eWhat \"Single Bottle Solution\" on our labels means\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eKalén A et al. Age-related changes in the lipid compositions of rat and human tissues. Lipids. 1989. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2779364\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eCooke M et al. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 2008. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18318910\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBhagavan HN et al. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16551570\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003ePacker L et al. alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med. 1995. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7649494\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSharman JE et al. Alpha-lipoic acid does not acutely affect resistance and conduit artery function or oxidative stress in healthy men. Br J Clin Pharmacol. 2004. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15327583\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHidaka T et al. Safety assessment of coenzyme Q10 (CoQ10). Biofactors. 2008. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19096117\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":44427130536218,"sku":"015-A7004","price":25.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/A7004_REV00_Listing_Image_1.png?v=1738257879"},{"product_id":"b-good-com-vitamin-b-complex","title":"B-Complex Complete Vitamin – Energy \u0026 Nerve Support | 60 Vegetarian Capsules","description":"\u003cp\u003e\u003cstrong\u003eB-Complex Complete Vitamin puts all eight B vitamins in one vegetarian capsule a day: 100 mg each of thiamin, riboflavin, niacinamide, vitamin B6 and pantothenic acid, plus 680 mcg DFE folic acid, 100 mcg vitamin B12 and 100 mcg biotin, with choline, inositol and PABA. Each bottle holds 60 capsules. It supports normal energy metabolism and nervous system function.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB vitamins don't hand you energy the way coffee does. They're the helpers your cells use to turn food into fuel, and your body keeps only small reserves of most of them.† B-Complex is for adults who want that covered in one step: people in their 30s and 40s building habits they plan to keep for decades, and anyone over 50 who intends to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003cp\u003eThe doses are high, so read \"How to take\" before you stack this with other B products.\u003c\/p\u003e\n\u003ch2\u003eWhy people take B-Complex\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy from food.\u003c\/strong\u003e Thiamin, riboflavin, niacinamide, pantothenic acid and biotin help your cells turn carbohydrates, fats and protein into usable energy.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNervous system function.\u003c\/strong\u003e Vitamin B6, folate and vitamin B12 help your body make neurotransmitters and support normal nerve function.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEveryday stress.\u003c\/strong\u003e B vitamins support a normal response to the ordinary stress of busy days.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMethylation and cell building.\u003c\/strong\u003e Folic acid, B6 and B12 work together in one-carbon metabolism, which your body uses to make DNA and build cells, including red blood cells.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFat and protein metabolism.\u003c\/strong\u003e Biotin and pantothenic acid help your body build and break down fatty acids and use amino acids.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eThiamin (thiamin HCl)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e8,333%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRiboflavin (vitamin B2)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e7,692%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNiacinamide\u003c\/td\u003e\n\u003ctd\u003e100 mg NE\u003c\/td\u003e\n\u003ctd\u003e625%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B6 (from pyridoxine HCl)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e5,882%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFolic Acid\u003c\/td\u003e\n\u003ctd\u003e680 mcg DFE\u003c\/td\u003e\n\u003ctd\u003e170%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B12 (cyanocobalamin)\u003c\/td\u003e\n\u003ctd\u003e100 mcg\u003c\/td\u003e\n\u003ctd\u003e4,166%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBiotin\u003c\/td\u003e\n\u003ctd\u003e100 mcg\u003c\/td\u003e\n\u003ctd\u003e333%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePantothenic Acid (from d-calcium pantothenate)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e2,000%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCholine (from choline bitartrate)\u003c\/td\u003e\n\u003ctd\u003e47 mg\u003c\/td\u003e\n\u003ctd\u003e8%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInositol\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePABA (para-aminobenzoic acid)\u003c\/td\u003e\n\u003ctd\u003e60 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 1 vegetarian capsule. At one capsule per serving, the 60-capsule bottle holds 60 servings. Other ingredients: Vegetable cellulose (preservative-free, from capsule shell), magnesium trisilicate, vegetable stearate, magnesium stearate, silica, and rice polish. The label states: \"NO corn, soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\"\u003c\/p\u003e\n\u003cp\u003eWhy the big percentages? The Daily Values for the five vitamins dosed at 100 mg run from 1.2 mg to 16 mg, so 100 mg works out to hundreds or thousands of percent. DFE means dietary folate equivalents, a unit that adjusts for folic acid being more easily absorbed than food folate.\u003c\/p\u003e\n\u003ch2\u003eHow B-Complex works\u003c\/h2\u003e\n\u003ch3\u003eThiamin, riboflavin, niacinamide and pantothenic acid: food into fuel\u003c\/h3\u003e\n\u003cp\u003eYour cells run on ATP, and the enzymes that make it need helper molecules built from B vitamins. A review of all eight describes them as coenzymes in energy production, DNA synthesis and repair, methylation, and making brain chemicals, and argues for getting all eight rather than just a few (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003eKennedy, 2016\u003c\/a\u003e).†\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eThiamin (thiamin HCl)\u003c\/strong\u003e becomes thiamin diphosphate, a cofactor for five enzymes in glucose, amino acid and fat metabolism. Thiamin HCl is one of the two most common supplement forms, both stable and water soluble (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Thiamin-HealthProfessional\/\"\u003eNIH thiamin fact sheet\u003c\/a\u003e).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRiboflavin\u003c\/strong\u003e is built into two coenzymes, FAD and FMN, that run energy production and fat metabolism. It also helps activate its teammates: FMN is needed to convert B6 into its coenzyme form (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Riboflavin-HealthProfessional\/\"\u003eNIH riboflavin fact sheet\u003c\/a\u003e).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNiacinamide\u003c\/strong\u003e, a form of vitamin B3, becomes NAD, a coenzyme more than 400 enzymes depend on. Unlike nicotinic acid, it doesn't cause skin flushing (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Niacin-HealthProfessional\/\"\u003eNIH niacin fact sheet\u003c\/a\u003e).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePantothenic acid (from d-calcium pantothenate)\u003c\/strong\u003e builds coenzyme A, which your body needs to make and break down fatty acids. Calcium pantothenate is more common in supplements than the other main form, pantethine (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/PantothenicAcid-HealthProfessional\/\"\u003eNIH pantothenic acid fact sheet\u003c\/a\u003e).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eVitamin B6, folic acid and B12: methylation and nerves\u003c\/h3\u003e\n\u003cp\u003eFolate carries single-carbon units for making DNA, and with B12's help it turns homocysteine into methionine, which the body uses to make SAMe, an important methyl donor (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Folate-HealthProfessional\/\"\u003eNIH folate fact sheet\u003c\/a\u003e). B12 is also needed for normal nervous system function and red blood cell formation (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH vitamin B12 fact sheet\u003c\/a\u003e), and B6 helps make several neurotransmitters (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003eKennedy, 2016\u003c\/a\u003e).†\u003c\/p\u003e\n\u003cp\u003eTo be candid, these are standard, well-studied forms, not pre-activated ones. Cyanocobalamin is the most common B12 in supplements, and your body converts it to the active forms (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH vitamin B12 fact sheet\u003c\/a\u003e). Pyridoxine HCl is the most common B6, and absorption doesn't differ much between B6 forms (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB6-HealthProfessional\/\"\u003eNIH vitamin B6 fact sheet\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eBiotin\u003c\/h3\u003e\n\u003cp\u003eBiotin is a cofactor for five carboxylase enzymes that handle steps in the metabolism of fatty acids, glucose and amino acids (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Biotin-HealthProfessional\/\"\u003eNIH biotin fact sheet\u003c\/a\u003e).†\u003c\/p\u003e\n\u003ch3\u003eCholine, inositol and PABA\u003c\/h3\u003e\n\u003cp\u003eYour body uses choline to build cell membranes and to make acetylcholine, a messenger for memory, mood and muscle control (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Choline-HealthProfessional\/\"\u003eNIH choline fact sheet\u003c\/a\u003e). A review estimated about 90% of Americans fall below the Adequate Intake for choline (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30853718\/\"\u003eWallace, 2018\u003c\/a\u003e). The 47 mg here is 8% of the Daily Value: a small contribution, not a full day's worth.† Inositol and PABA are traditional B-complex companions with no Daily Value, and we don't claim a specific benefit for either.\u003c\/p\u003e\n\u003ch3\u003eWhat the research shows, and what it doesn't\u003c\/h3\u003e\n\u003cp\u003eThe most relevant trials of high-dose B-complex formulas enrolled healthy, working adults. In one, 215 men aged 30 to 55 took a B-complex with vitamin C and minerals or a placebo for 33 days. The supplement group rated their stress lower and their vigor higher, did better on a mental math task, and felt less mentally tired before and after an hour of demanding tests (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20454891\/\"\u003eKennedy, 2010\u003c\/a\u003e). In phone check-ins with 198 men from the same group over four weeks, the supplement group rated their physical stamina higher and reported more concentration and mental stamina after a workday (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21751253\/\"\u003eKennedy, 2011\u003c\/a\u003e). In a 90-day trial, 60 adults under ongoing work stress who took a high-dose B-complex reported lower personal strain, less confusion and a less dejected mood than the placebo group at 12 weeks, with no change in other mood measures (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21905094\/\"\u003eStough, 2011\u003c\/a\u003e).†\u003c\/p\u003e\n\u003cp\u003eThe limits: those formulas differ from ours (the 215-man trial's also included vitamin C and minerals), the trials were modest in size, and most of the effects were changes in how people rated themselves. B-Complex itself hasn't been tested in a trial.\u003c\/p\u003e\n\u003ch2\u003eHow to take B-Complex\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDirections on the label:\u003c\/strong\u003e One capsule daily, as a dietary supplement.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKnow your totals.\u003c\/strong\u003e One capsule's 100 mg of B6 equals the adult \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB6-HealthProfessional\/\"\u003eTolerable Upper Intake Level (UL) for vitamin B6\u003c\/a\u003e set by the Food and Nutrition Board. It also supplies 100 mg of niacinamide, and the board's \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Niacin-HealthProfessional\/\"\u003e35 mg UL for supplemental niacin\u003c\/a\u003e applies to niacinamide too. Neither limit applies when a practitioner directs a higher intake, but both are a reason not to add other B6 or niacin products on your own.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of B-Complex has its own.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA with globally sourced ingredients, in Mt. Angel, Oregon.\u003c\/strong\u003e B-Complex is made and tested in a farm town of about 3,500 people in the Willamette Valley, inside a UL-certified cGMP facility where formulators, makers and testers work under one roof. The owners work in the building too, and the company has been owner-run since 2017. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow many capsules of B-Complex should I take?\u003c\/h3\u003e\n\u003cp\u003eOne capsule a day, as the label directs. A 60-capsule bottle lasts 60 days at that serving.\u003c\/p\u003e\n\u003ch3\u003eShould I take B-Complex with food or at a certain time?\u003c\/h3\u003e\n\u003cp\u003eThe label doesn't specify either, so choose a time you'll stick with.\u003c\/p\u003e\n\u003ch3\u003eWhy does my urine turn bright yellow?\u003c\/h3\u003e\n\u003cp\u003eThat's the riboflavin (vitamin B2). It's naturally yellow, and the small amount you absorb beyond what your body needs leaves in urine. It's expected. No upper limit has been set for riboflavin because adverse effects from high intakes haven't been reported, though the Food and Nutrition Board still advises caution with very large amounts.\u003c\/p\u003e\n\u003ch3\u003eHow long until I notice a difference?\u003c\/h3\u003e\n\u003cp\u003eGive it at least a month. B vitamins aren't stimulants, and in the trials above, changes were measured over 4 to 12 weeks.† If your diet already supplies plenty of B vitamins, you may notice little.\u003c\/p\u003e\n\u003ch3\u003eCan I take B-Complex with a multivitamin or other B products?\u003c\/h3\u003e\n\u003cp\u003eYes, but add up the B6 and niacin first and check with your practitioner, since one capsule already reaches the adult UL for B6. Our \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-sublingual-essential-trio\"\u003eB-12 Essential Trio liquid\u003c\/a\u003e adds 4 mg of B6 per serving. If you want more B12 without more B6, our \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-dots-energy-nervous-support\"\u003eTriple B-12 Dots, 1,000 mcg of cyanocobalamin-free B12 per dot\u003c\/a\u003e, contain no B6.\u003c\/p\u003e\n\u003ch3\u003eIs B-Complex safe with my medications?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first. Also tell whoever orders your bloodwork that you take biotin, since intakes above the recommended amount can skew some lab results. Our \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/tools\/interaction-checker\"\u003esupplement and medication interaction checker\u003c\/a\u003e is a good place to start.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mens-multi-vitamin-60-capsules\"\u003eMen's Multi: vitamins, minerals, KSM-66 ashwagandha and CoQ10 in two capsules a day\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/womens-multi-cap-60ct\"\u003eWomen's Multi: vitamins, minerals, KSM-66 ashwagandha and CoQ10 in two capsules a day\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eKennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKennedy DO et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology. 2010. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20454891\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKennedy DO et al. Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Hum Psychopharmacol. 2011. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21751253\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eStough C et al. The effect of 90 day administration of a high dose vitamin B-complex on work stress. Hum Psychopharmacol. 2011. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21905094\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWallace TC et al. Choline: The Underconsumed and Underappreciated Essential Nutrient. Nutr Today. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30853718\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":51646906040602,"sku":"015-A2207","price":25.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/A2207_REV00_Listing_Image_1.png?v=1769810719"},{"product_id":"b12-sublingual-essential-trio","title":"B-12 Essential Trio – B12, Folinate \u0026 B6 for Energy Metabolism | 2 fl oz Liquid","description":"\u003cp\u003e\u003cstrong\u003eB-12 Essential Trio is a blueberry-flavored liquid with three B vitamins. One serving (a single dropper bulb squeeze, about 0.84 grams) gives 2,000 mcg of vitamin B12 as methylcobalamin, 680 mcg DFE of folate as folinate and 4 mg of vitamin B6. Each 2 fl oz bottle holds 80 servings. Together, these vitamins support normal energy metabolism and healthy homocysteine metabolism.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB12 occurs naturally only in animal foods, so anyone eating little or no meat, fish, eggs or dairy may need another source. The NIH also advises people over 50 to get most of their B12 from fortified foods or supplements, since many older adults don't make enough stomach acid to free B12 from food (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-Consumer\/\"\u003ethe NIH's consumer guide to vitamin B12\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003eIf you're in your 30s or 40s and building habits so you can keep up at 75, half a dropper each morning is about as easy as a habit gets. No pills to swallow. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take B-12 Essential Trio\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports normal energy metabolism, because B12 and B6 are coenzymes your cells use to turn parts of protein and fat into fuel.†\u003c\/li\u003e\n\u003cli\u003eSupports healthy homocysteine levels already within the normal range, as B12 and folate recycle homocysteine into methionine.†\u003c\/li\u003e\n\u003cli\u003eSupports normal red blood cell formation and DNA synthesis, with folate and B12 working together.†\u003c\/li\u003e\n\u003cli\u003eSupports healthy nervous system function.†\u003c\/li\u003e\n\u003cli\u003eHelps people who eat few animal foods, and adults over 50, keep B12 intake up.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B6 (from Pyridoxine HCl)\u003c\/td\u003e\n\u003ctd\u003e4 mg\u003c\/td\u003e\n\u003ctd\u003e235%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFolinate (from Calcium Folinate)\u003c\/td\u003e\n\u003ctd\u003e680 mcg DFE\u003c\/td\u003e\n\u003ctd\u003e170%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B12 (Methylcobalamin)\u003c\/td\u003e\n\u003ctd\u003e2,000 mcg\u003c\/td\u003e\n\u003ctd\u003e83,333%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 1 Dropper Bulb Squeeze (Approximately half a dropper full, Approximately 0.84 grams). Servings per container: 80. Other ingredients: Vegetable Glycerin, Purified Water, Citric Acid, Potassium Sorbate, and Natural Blueberry Flavor. The label states: \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or artificial colors or flavors.\" It also says: \"Refrigerate after opening.\" Potassium sorbate is a preservative.\u003c\/p\u003e\n\u003ch2\u003eHow B-12 Essential Trio works\u003c\/h2\u003e\n\u003ch3\u003eMethylcobalamin (2,000 mcg): B12 for the methylation cycle\u003c\/h3\u003e\n\u003cp\u003eB12 is a coenzyme, a helper molecule two enzymes can't work without, and methylcobalamin is one of the two forms your cells use in that role (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e). It partners with methionine synthase, the enzyme that recycles homocysteine into methionine, which your body turns into SAMe, its most important methyl donor. That same step pulls a one-carbon unit off folate so folate can keep cycling into DNA building blocks, which is why B12 and folate come as a pair. B12's other coenzyme form helps your mitochondria turn leftovers from breaking down certain amino acids into fuel (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\"\u003eFroese et al., 2019\u003c\/a\u003e).†\u003c\/p\u003e\n\u003cp\u003eStraight talk: your cells process any B12 they absorb before using it, and the NIH says there's no evidence that absorption differs by form. We chose methylcobalamin because it's one of the two coenzyme forms, not because we can show it's absorbed or used better.\u003c\/p\u003e\n\u003ch3\u003eWhy 2,000 mcg when the Daily Value is 2.4 mcg\u003c\/h3\u003e\n\u003cp\u003eBecause the share you absorb drops as the dose rises: the NIH puts absorption near 50% for doses under 1 to 2 mcg but about 1.3% of a 1,000 mcg dose. A systematic review saw the same pattern with food: people absorbed 83% of a 3 mcg dose but only 4.5% of a 38 mcg dose (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23796635\/\"\u003eDoets et al., 2013\u003c\/a\u003e). A big dose offsets a small percentage.\u003c\/p\u003e\n\u003ch3\u003eFolinate (680 mcg DFE): folate that skips a slow step\u003c\/h3\u003e\n\u003cp\u003eFolate carries the one-carbon units your cells need to build DNA and keep the methionine cycle turning.† Most supplements use folic acid, a fully oxidized form your body must first convert with an enzyme called DHFR; food folates are already in the reduced tetrahydrofolate form (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Folate-HealthProfessional\/\"\u003eNIH fact sheet on folate\u003c\/a\u003e). In liver tissue from six people, DHFR converted folic acid at less than 2% of the rate seen in rat liver, and activity varied almost fivefold between people (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19706381\/\"\u003eBailey and Ayling, 2009\u003c\/a\u003e). Folinate is a formyl form of tetrahydrofolate, the same reduced family as food folate, so it doesn't wait on DHFR. To be fair, that was a lab study, not a supplement trial, and the NIH puts folic acid absorption at about 85% with food. Folinate just takes one step out of the way.\u003c\/p\u003e\n\u003ch3\u003eVitamin B6 (4 mg from pyridoxine HCl): the protein-metabolism helper\u003c\/h3\u003e\n\u003cp\u003eYour body turns pyridoxine into pyridoxal 5' phosphate (PLP), the coenzyme form of B6, which takes part in more than 100 enzyme reactions, mostly in protein metabolism (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB6-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B6\u003c\/a\u003e).† One review names B6, B12 and folate as the B vitamins most involved in homocysteine metabolism, and describes the B group's roles in energy production, DNA synthesis and making the brain's chemical messengers (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003eKennedy, 2016\u003c\/a\u003e).† Pyridoxine HCl is the most common B6 form in supplements; if you want B6 already in coenzyme form, that's \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/p5p-50mg-vitamin-b6-supplement\"\u003eour P5P 50 mg\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eWhat the research does and doesn't show\u003c\/h3\u003e\n\u003cp\u003eWhat it shows: a pooled analysis of 25 randomized trials with 2,596 participants found folic acid reduced blood homocysteine by 13% to 25%, depending on dose; B12 (0.4 mg a day) brought it down about 7% more, and B6 had no significant effect (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16210710\/\"\u003eHomocysteine Lowering Trialists' Collaboration, 2005\u003c\/a\u003e). Those trials used folic acid, not folinate, and none tested this product.\u003c\/p\u003e\n\u003cp\u003eWhat it doesn't show: that B vitamins sharpen your thinking. A systematic review of 14 randomized trials found no clear effect of B6, B12 or folic acid on cognitive test scores, and most trials were small or low quality (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17210874\/\"\u003eBalk et al., 2007\u003c\/a\u003e). We haven't run a trial on B-12 Essential Trio itself; what we can show you is what's in each serving and how every lot is tested.\u003c\/p\u003e\n\u003ch2\u003eHow to take B-12 Essential Trio\u003c\/h2\u003e\n\u003cp\u003eThe label directions, word for word: \"Take one serving by mouth in the morning.\" One serving is a single squeeze of the dropper bulb, which fills about half the dropper.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSqueeze the bulb once, release, and drip the liquid into your mouth, or into a little water or juice.\u003c\/li\u003e\n\u003cli\u003eRefrigerate after opening, as the label says.\u003c\/li\u003e\n\u003cli\u003eAt one serving each morning, a bottle's 80 servings last 80 days.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. The label gives no serving for children, so check with your child's practitioner first. Acid-reducing medicines can make it harder to absorb B12 from food.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. Fifty-two years in, here's how we back up this label:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the methylcobalamin, folinate and B6 included, for identity, potency, heavy metals and microbes. Here's \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/our-approach-to-raw-material-sourcing-and-testing\"\u003ehow we source and test raw materials\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/b12-sublingual-essential-trio\"\u003eSee the certificates of analysis for this product\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e B-12 Essential Trio is made in our UL-certified cGMP facility in Mt. Angel, a farm town of about 3,500 in the Willamette Valley. The people who formulate, make and test it work under one roof, and the owners work in the building too. We're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much B12, folate and B6 is in one serving?\u003c\/h3\u003e\n\u003cp\u003eOne serving has 2,000 mcg of vitamin B12 as methylcobalamin (83,333% of the Daily Value), 680 mcg DFE of folate as folinate (170%) and 4 mg of vitamin B6 from pyridoxine HCl (235%).\u003c\/p\u003e\n\u003ch3\u003eIs B-12 Essential Trio a sublingual B12?\u003c\/h3\u003e\n\u003cp\u003eYou can take it that way; the label simply says to take one serving by mouth in the morning. Holding it under your tongue first is fine, though the NIH says evidence suggests no difference in efficacy between oral and sublingual B12.\u003c\/p\u003e\n\u003ch3\u003eIs 2,000 mcg of B12 too much?\u003c\/h3\u003e\n\u003cp\u003eIt's a large dose, but no upper limit has been set for vitamin B12 because of its low potential for toxicity, and you absorb only a small share of it. The 4 mg of B6 is well under the 100 mg adult upper limit. If you take medication, check with your practitioner first.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with B-Complex or Triple B-12 Dots?\u003c\/h3\u003e\n\u003cp\u003eCheck the totals first, because they overlap. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b-good-com-vitamin-b-complex\"\u003eOur B-Complex with all eight B vitamins\u003c\/a\u003e already has 100 mg of B6 per capsule, so adding B-12 Essential Trio brings B6 to 104 mg a day, just over the 100 mg adult upper limit. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-dots-energy-nervous-support\"\u003eTriple B-12 Dots\u003c\/a\u003e add 1,000 mcg of B12 per dot, which you likely don't need on top of 2,000 mcg. Most people pick one, or ask a practitioner first.\u003c\/p\u003e\n\u003ch3\u003eHow soon will I notice a difference?\u003c\/h3\u003e\n\u003cp\u003eThere's no jolt, because B vitamins aren't stimulants; they keep enzymes supplied. If your intake was already good, you may not feel a difference at all, and that's normal.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eFroese DS et al. Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDoets EL et al. Systematic review on daily vitamin B12 losses and bioavailability for deriving recommendations on vitamin B12 intake with the factorial approach. Ann Nutr Metab. 2013. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23796635\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBailey SW et al. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci U S A. 2009. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19706381\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHomocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16210710\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBalk EM et al. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch Intern Med. 2007. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17210874\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"1","offer_id":44364424479002,"sku":"015-M2210","price":25.99,"currency_code":"USD","in_stock":true},{"title":"3","offer_id":44900315201818,"sku":"015-M2210-3","price":69.99,"currency_code":"USD","in_stock":true},{"title":"5","offer_id":44900315234586,"sku":"015-M2210-5","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M2210_REV02_Box.png?v=1738258018"},{"product_id":"good-energy-stamina-support","title":"Good Energy+ – Energy \u0026 Endurance Support | 60 Vegetarian Capsules","description":"\u003cp\u003e\u003cstrong\u003eGood Energy+ is a caffeinated energy and endurance supplement in 60 vegetarian capsules, 30 servings per bottle. Each 2-capsule serving delivers 400 mg Rhodiola rosea root extract (1% salidrosides), 100 mg Panax ginseng root extract (4% ginsenosides) and 100 mg caffeine (42 mg from yerba mate, 58 mg added), plus a 1,002 mg proprietary blend, to support energy, alertness and endurance.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGood Energy+ is for the days that ask a lot: the early workout, the packed calendar, the 2 p.m. slump. It fits people in their 30s and 40s building habits now so they can keep doing what they love in their 70s and 80s, and people past 50 with zero plans to slow down. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003cp\u003eIt isn't a stand-in for sleep, food or water. It's measured caffeine plus Rhodiola and ginseng, with the key amounts on the panel.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Good Energy+\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEndurance.\u003c\/strong\u003e Rhodiola rosea supports physical endurance during exercise, with the most consistent research on single doses taken before a workout.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlertness.\u003c\/strong\u003e 100 mg of caffeine per serving supports alertness, attention and reaction time.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMental performance.\u003c\/strong\u003e Caffeine supports mental performance on demanding days, with Panax ginseng playing a supporting part.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy you can measure.\u003c\/strong\u003e Supports energy for your workday or workout, with the exact caffeine amount and its sources printed on the label.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eRhodiola rosea\u003c\/em\u003e Root Standardized Extract (standardized to 1% salidrosides)\u003c\/td\u003e\n\u003ctd\u003e400 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003ePanax ginseng\u003c\/em\u003e Root Standardized Extract (standardized to 4% ginsenosides by HPLC)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCaffeine (42mg from Yerba Matte, 58mg from added caffeine)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eProprietary Blend (Contains: Yerba matte Leaf Standardized Extract (Ilex paraguariensis), Sea Buckthorn Berry Extract (Hippophae rhamnoides), Goji Fruit Extract (Lycium barbarum), Bromelain (1200 GDU\/g), Royal Jelly Standardized Concentrate (contains 4.0% 10-hydroxy-2-decenoic acid), Eleutherococcus senticosus Root 50:1 Extract, and Bioperine®.)\u003c\/td\u003e\n\u003ctd\u003e1,002 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*Daily Value not established.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing size:\u003c\/strong\u003e 2 Vegetarian Capsules. \u003cstrong\u003eServings per container:\u003c\/strong\u003e 30. \u003cstrong\u003eOther ingredients:\u003c\/strong\u003e Vegetable cellulose (preservative-free, from capsule shell), magnesium stearate, and silica. The front of the bottle states \"CONTAINS 100MG CAFFEINE\", and the panel notes \"Bioperine® Licensed Under US Patent Numbers 5,536,161; 5,744,382; and 6,054,585\".\u003c\/p\u003e\n\u003ch2\u003eHow Good Energy+ works\u003c\/h2\u003e\n\u003ch3\u003eRhodiola rosea: 400 mg, standardized to 1% salidrosides\u003c\/h3\u003e\n\u003cp\u003eRhodiola is a hardy plant from high, harsh climates in Europe and Asia. Our root extract is standardized to 1% salidrosides, one of the marker compounds researchers measure in Rhodiola, so every lot has to hit the same level instead of being \"some amount of ground root.\"\u003c\/p\u003e\n\u003cp\u003eThe research is most consistent for endurance. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15256690\/\"\u003ea double-blind trial in 24 young, healthy volunteers\u003c\/a\u003e, a single 200 mg dose taken an hour before testing increased time to exhaustion from 16.8 to 17.2 minutes on average. A small gain, and four weeks of daily use didn't add to it. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37495266\/\"\u003eA 2023 systematic review of 13 randomized trials in 263 healthy adults\u003c\/a\u003e found single pre-exercise doses had a positive effect on endurance and on how hard exercise felt, while longer-term use helped short, intense (anaerobic) efforts but not endurance.† Most studies had an unclear or high risk of bias, so more high-quality trials are needed. Good Energy+ provides 400 mg, but extracts and doses in these trials varied, so results don't transfer one-for-one.\u003c\/p\u003e\n\u003ch3\u003ePanax ginseng: 100 mg, standardized to 4% ginsenosides\u003c\/h3\u003e\n\u003cp\u003ePanax ginseng is a root with a long history of traditional use in East Asia. Its main active compounds are ginsenosides, and ours are measured by HPLC, a lab method that separates and quantifies the individual compounds.\u003c\/p\u003e\n\u003cp\u003eThe human research is real but mixed. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20737519\/\"\u003ea crossover trial in 30 healthy young adults\u003c\/a\u003e, 400 mg of a standardized extract improved mental arithmetic and ratings of calmness, while 200 mg slowed the usual drop in mood but also slowed responses on the math task. A week of daily use added nothing beyond the first dose.† At 100 mg, ginseng is a supporting player here, not the headliner.\u003c\/p\u003e\n\u003ch3\u003eCaffeine: 100 mg, with the sources spelled out\u003c\/h3\u003e\n\u003cp\u003eThrough the day, a compound called adenosine builds up in the brain and nudges you toward feeling tired. Caffeine blocks adenosine's receptors, so that signal gets muffled for a while. Each serving has 100 mg: 42 mg from yerba mate leaf extract and 58 mg of added caffeine.\u003c\/p\u003e\n\u003cp\u003eYou don't need a huge dose to notice it. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3114783\/\"\u003ea controlled study of low caffeine doses in 20 healthy men\u003c\/a\u003e, single doses from 32 to 256 mg each improved auditory vigilance and visual reaction time, with no adverse behavioral effects noted.† \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25355191\/\"\u003eA review of low-dose caffeine and exercise\u003c\/a\u003e found that about 200 mg or less can support vigilance, alertness and mood during and after exercise with few if any side effects, though responses vary.† A \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28438661\/\"\u003elarge systematic review of caffeine safety\u003c\/a\u003e concluded that up to 400 mg a day isn't associated with overt adverse effects in healthy adults.\u003c\/p\u003e\n\u003ch3\u003eThe 1,002 mg proprietary blend\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eYerba mate leaf extract\u003c\/strong\u003e (\u003cem\u003eIlex paraguariensis\u003c\/em\u003e): the South American leaf brewed as mate tea, and the source of 42 mg of the caffeine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSea buckthorn berry\u003c\/strong\u003e and \u003cstrong\u003egoji fruit\u003c\/strong\u003e extracts: two berries from Europe and Asia.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBromelain (1200 GDU\/g)\u003c\/strong\u003e: protein-digesting enzymes from pineapple. GDU measures enzyme activity, not just weight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoyal jelly concentrate\u003c\/strong\u003e: made by worker bees to feed developing bees and the queen, standardized to 4.0% 10-HDA, a fatty acid characteristic of royal jelly.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEleutherococcus senticosus root 50:1 extract\u003c\/strong\u003e (eleuthero): roughly 50 parts raw root concentrated into each part of extract.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBioperine®\u003c\/strong\u003e: a black pepper extract standardized for piperine.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTo be candid: the label lists the blend as one total, so we don't make specific claims for individual blend ingredients. The three ingredients with printed amounts are the ones you can check.\u003c\/p\u003e\n\u003ch2\u003eHow to take Good Energy+\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDirections (from the label):\u003c\/strong\u003e \"Take two capsules prior to a meal, in the morning or afternoon, as a dietary supplement.\"\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCount your caffeine.\u003c\/strong\u003e Add the 100 mg per serving to your coffee, tea, soda, pre-workout and energy drinks.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep it to the morning or afternoon,\u003c\/strong\u003e as the label says. Late-day caffeine can get in the way of a good night's sleep.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBefore a workout:\u003c\/strong\u003e the most promising Rhodiola research used a single dose about an hour before exercise.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIf you react to bee products (royal jelly) or caffeine makes you jittery, ask your practitioner first. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. Because it contains caffeine, store it out of reach of children.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. After 52 years, we'd still rather show you the work than ask for your trust.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming ingredient lot, from the Rhodiola to the yerba mate, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e That includes Good Energy+.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e That's a farm town of about 3,500 people in the Willamette Valley. Good Energy+ is made in our UL-certified cGMP facility, where the formulators, makers and testers work under one roof and the owners work in the building too. Owner-run since 2017, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much caffeine is in Good Energy+?\u003c\/h3\u003e\n\u003cp\u003eEach 2-capsule serving has 100 mg of caffeine: 42 mg from yerba mate leaf extract and 58 mg added. That's a quarter of the 400 mg a day the caffeine safety review above found isn't associated with overt adverse effects in healthy adults, so count it with your other sources.\u003c\/p\u003e\n\u003ch3\u003eWhen should I take it, and with food?\u003c\/h3\u003e\n\u003cp\u003eTake two capsules prior to a meal, in the morning or afternoon, as the label directs. Before breakfast or lunch works, and it keeps the caffeine out of your evening.\u003c\/p\u003e\n\u003ch3\u003eHow soon will I notice it?\u003c\/h3\u003e\n\u003cp\u003eThe caffeine works the day you take it. The Rhodiola endurance trial above tested one hour after a single dose, and four weeks of daily use added nothing more, so judge it day by day.†\u003c\/p\u003e\n\u003ch3\u003eCan I take it with Adrenal Support or a B vitamin?\u003c\/h3\u003e\n\u003cp\u003eThey can be used together, but know the overlap. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/adrenal-support-60-vegetarian\"\u003eAdrenal Support\u003c\/a\u003e also contains Rhodiola root extract (1% salidrosides) and Eleutherococcus senticosus root 50:1 extract, so you'd get more of both. For energy support without more caffeine, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-sublingual-essential-trio\"\u003eB-12 Essential Trio\u003c\/a\u003e and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b-good-com-vitamin-b-complex\"\u003eB-Complex\u003c\/a\u003e are B vitamin formulas (neither label lists caffeine) that support normal energy metabolism.†\u003c\/p\u003e\n\u003ch3\u003eDoes Good Energy+ support healthy blood sugar?\u003c\/h3\u003e\n\u003cp\u003eThat isn't what it's labeled for. Good Energy+ is formulated for energy and endurance, and that's the job we stand behind. If supporting healthy blood sugar levels already within the normal range is your main goal, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/blood-sugar-support-60ct-caps\"\u003eBlood Sugar Support\u003c\/a\u003e is the formula we make for that.†\u003c\/p\u003e\n\u003ch3\u003eIs it safe to take with my medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner before you start. Bring the bottle so they can check the caffeine, botanicals and royal jelly against what you take.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/our-approach-to-formulation\"\u003eHow our formulator decides which ingredients belong together\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/energy-focus-stack-adrenal-b12\"\u003eEnergy \u0026amp; Focus Stack: Adrenal Support, B-12 Essential Trio and B-Complex\u003c\/a\u003e (none of the three labels lists caffeine)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eDe Bock K et al. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15256690\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSanz-Barrio PM et al. Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials. Phytother Res. 2023. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37495266\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eReay JL et al. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol. 2010. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20737519\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLieberman HR et al. The effects of low doses of caffeine on human performance and mood. Psychopharmacology (Berl). 1987. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3114783\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSpriet LL. Exercise and sport performance with low doses of caffeine. Sports Med. 2014. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25355191\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWikoff D et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol. 2017. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28438661\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":44364422283546,"sku":"010-A1029","price":31.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/A3008_Bottle_Mockup_Center.png?v=1738258710"},{"product_id":"nmn-nr-cellular-wellness-supplement","title":"NMN + NR with Resveratrol and TMG – NAD+ \u0026 Cellular Energy Support | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eNMN + NR with Resveratrol and TMG is a 60-capsule NAD+ formula. Each 2-capsule serving provides 500 mg β-nicotinamide mononucleotide (NMN), 200 mg nicotinamide riboside (NR), 250 mg resveratrol, 50 mg TMG, 50 mg Bioperine® black pepper extract and 10 mg zinc (as bisglycinate chelate), to support cellular energy production and healthy NAD+ levels.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNMN and NR are two building blocks your body uses to make NAD+, which every cell needs for energy and upkeep. This formula puts both in one bottle. It's built for people in their late 30s and 40s who are already working on energy and cellular health, and for anyone over 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take NMN + NR\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealthy NAD+ levels.\u003c\/strong\u003e NMN and NR are both NAD+ precursors, and each raised blood NAD+ in placebo-controlled trials in healthy adults.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular energy.\u003c\/strong\u003e Your mitochondria use NAD+ to turn food into ATP, the energy your cells run on.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNormal DNA repair.\u003c\/strong\u003e PARPs, enzymes involved in routine DNA repair, need NAD+ to work, and so do sirtuins.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant support.\u003c\/strong\u003e Resveratrol is a plant polyphenol studied for its role in the body's normal defenses against everyday oxidative stress.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMethylation and enzyme support.\u003c\/strong\u003e TMG donates methyl groups for normal methylation, and zinc helps hundreds of enzymes work.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eβ-Nicotinamide Mononucleotide\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root)\u003c\/td\u003e\n\u003ctd\u003e250 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide riboside\u003c\/td\u003e\n\u003ctd\u003e200 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTrimethylglycine (TMG) (Betaine anhydrous)\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit)\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (as bisglycinate chelate)\u003c\/td\u003e\n\u003ctd\u003e10 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*Daily Value not established, as printed on the label. Serving size: 2 capsules. Servings per container: 30. Other ingredients: Vegetarian Capsule (Hypromellose and water), organic brown rice and magnesium stearate. The label states: \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\" Bioperine® is a registered trademark of Sabinsa Corporation.\u003c\/p\u003e\n\u003ch2\u003eHow NMN + NR works\u003c\/h2\u003e\n\u003ch3\u003eNMN (β-nicotinamide mononucleotide), 500 mg\u003c\/h3\u003e\n\u003cp\u003eNMN is one step away from NAD+ (nicotinamide adenine dinucleotide), a coenzyme in every cell. Mitochondria use NAD+ to make ATP, and sirtuins and PARPs use it up as they work, so cells keep rebuilding it, and NMN is one of the pieces.† Edamame, broccoli and meat contain it, but only about 1 mg per 100 grams, as the authors of \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35927255\/\"\u003ea 12-week NMN trial in healthy older men\u003c\/a\u003e note.\u003c\/p\u003e\n\u003cp\u003eIn that trial, 42 healthy men aged 65 and older were randomized to 250 mg of NMN or placebo daily, though a supplier mix-up left 12-week results for only 20 of them. NMN raised NAD+ in whole blood and was well tolerated. Gait speed and left-hand grip showed nominal gains the authors say larger studies must confirm, and muscle mass didn't change. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ea 60-day dose-comparison trial in 80 healthy middle-aged adults\u003c\/a\u003e, 300, 600 or 900 mg a day raised blood NAD+ in every group, most at 600 and 900 mg, and six-minute walk distance rose more than with placebo. Several authors work for chemical and biotech companies, so it's worth seeing repeated. On safety, in \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36002548\/\"\u003ea four-week placebo-controlled safety trial in 31 healthy adults\u003c\/a\u003e funded by an NMN maker, 1,250 mg a day produced no changes beyond normal variation.\u003c\/p\u003e\n\u003cp\u003eWhat it doesn't show: these trials ran weeks, not years, higher blood NAD+ isn't proof of a change you'll feel, and we haven't found a trial of this exact combination. Our \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/nad-longevity-complete-guide\"\u003eguide to how NAD+ works and why levels change with age\u003c\/a\u003e goes deeper.\u003c\/p\u003e\n\u003ch3\u003eNR (nicotinamide riboside), 200 mg\u003c\/h3\u003e\n\u003cp\u003eNR is a form of vitamin B3. Inside cells, an enzyme called NRK turns NR into NMN, which then becomes NAD+. NMN can also be converted to NR outside cells and rebuilt inside. So the two are neighbors on the same road, and taking both offers two entry points.†\u003c\/p\u003e\n\u003cp\u003eIn \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ea crossover trial in 30 healthy adults aged 55 to 79\u003c\/a\u003e, 500 mg of NR twice a day for six weeks was well tolerated and raised NAD+ in blood cells by about 60% versus placebo. The 200 mg here is a supporting dose, not a copy of that trial.\u003c\/p\u003e\n\u003ch3\u003eResveratrol, 250 mg from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e root\u003c\/h3\u003e\n\u003cp\u003eResveratrol is a polyphenol best known from grape skins; ours comes from Japanese knotweed (\u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) root. Lab research studies how it interacts with sirtuins, the NAD+-using enzymes above, which is why it's often paired with NAD+ precursors. We haven't found human trials of that pairing, and little of a resveratrol dose reaches the blood intact (low bioavailability).\u003c\/p\u003e\n\u003cp\u003eIn \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24804871\/\"\u003ea small single-dose study of resveratrol with and without piperine\u003c\/a\u003e, 23 adults took placebo, 250 mg of trans-resveratrol, or the same with 20 mg of piperine, on separate days. Thinking-task scores and mood didn't change, though the pair increased blood flow in the front of the brain during tasks. In a separate group of six, piperine didn't raise blood resveratrol. Interesting, early, and one study.\u003c\/p\u003e\n\u003ch3\u003eTMG (trimethylglycine), 50 mg\u003c\/h3\u003e\n\u003cp\u003eTMG, also called betaine, carries three methyl groups and hands them off in a process called methylation.† Why it's here: the body clears some of the nicotinamide left over from NAD+ use by attaching methyl groups to it, and TMG is a methyl donor. That's a sensible rationale, not a tested result. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14652361\/\"\u003ea six-week betaine trial in healthy men and women\u003c\/a\u003e, 1.5 to 6 grams a day lowered fasting homocysteine 12 to 20% versus placebo. A serving here has 50 mg, so we don't claim that effect.\u003c\/p\u003e\n\u003ch3\u003eBioperine® (black pepper fruit extract), 50 mg\u003c\/h3\u003e\n\u003cp\u003eBioperine® is a black pepper extract rich in piperine, which can change how the body absorbs and breaks down some compounds. The resveratrol study above found no rise in blood levels, so we don't promise one.\u003c\/p\u003e\n\u003ch3\u003eZinc (as bisglycinate chelate), 10 mg\u003c\/h3\u003e\n\u003cp\u003eZinc is needed for the activity of hundreds of enzymes and plays a role in making protein and DNA and in normal cell division, per the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Zinc-HealthProfessional\/\"\u003eNIH Office of Dietary Supplements zinc fact sheet\u003c\/a\u003e.† Bisglycinate chelate means the zinc is bound to the amino acid glycine. The adult RDA is 8 mg for women and 11 mg for men, and the adult upper limit from all sources is 40 mg a day.\u003c\/p\u003e\n\u003ch2\u003eHow to take NMN + NR\u003c\/h2\u003e\n\u003cp\u003eDirections: Take 2 capsules daily, as a dietary supplement. That one 2-capsule serving a day makes each 60-capsule bottle a 30-day supply.\u003c\/p\u003e\n\u003cp\u003eIf you take other zinc, as in a multivitamin, add up your daily total and keep it under the 40 mg adult upper limit.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are rejected.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003eSee the certificates of analysis for this product\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and we make and test this formula there in our UL-certified cGMP facility. Formulators, makers and testers work under one roof, and the owners work in the building too (owner-run since 2017). We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much NMN and NR is in each serving?\u003c\/h3\u003e\n\u003cp\u003eEach 2-capsule serving has 500 mg of NMN and 200 mg of NR, plus 250 mg of resveratrol, 50 mg of TMG, 50 mg of Bioperine® and 10 mg of zinc. Trials in healthy adults have used up to 900 mg of NMN a day for 60 days and 1,250 mg a day for four weeks without safety problems, though longer-term data at these amounts are limited.\u003c\/p\u003e\n\u003ch3\u003eWhy combine NMN and NR?\u003c\/h3\u003e\n\u003cp\u003eIt gives your body two entry points into the same NAD+ pathway.† We haven't found a trial comparing the pair with an equal amount of either one alone, so it's a reasonable design, not a proven advantage. Here's \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/nmn-vs-nicotinamide-riboside\"\u003ehow NMN and NR differ\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow long before I notice anything?\u003c\/h3\u003e\n\u003cp\u003eNo one can promise a timeline. Blood NAD+ was already higher at the 30-day check in one trial, but NAD+ isn't something you feel like coffee, and most trials above ran 6 to 12 weeks.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with Urolithin A?\u003c\/h3\u003e\n\u003cp\u003eYes. Our \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack\u003c\/a\u003e pairs one bottle each of NMN + NR and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A 500 mg\u003c\/a\u003e. Urolithin A is studied for how cells recycle worn-out mitochondria, while NMN and NR supply NAD+ building blocks.†\u003c\/p\u003e\n\u003ch3\u003eIs it safe with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner before combining it with medication. Piperine, the main compound in Bioperine®, can change how the body absorbs and processes some compounds, and NAD+ precursors haven't been studied alongside most prescriptions.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/nmn-nicotinamide-mononucleotide\"\u003eWhat the human research says about NMN, dose by dose\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/urolithin-a-vs-nmn\"\u003eHow urolithin A and NMN work differently, and which to start with\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eIgarashi M et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35927255\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eFukamizu Y et al. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Sci Rep. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36002548\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWightman EL et al. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr. 2014. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24804871\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eOlthof MR et al. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14652361\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":50096171581722,"sku":"015-M1026","price":59.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M1026_REV01_New_Item.png?v=1738258899"},{"product_id":"p5p-50mg-vitamin-b6-supplement","title":"P5P 50 mg Pyridoxal-5-Phosphate – Active B6 for Energy | 60 Vegetarian Capsules","description":"\u003cp\u003e\u003cstrong\u003eP5P 50 mg is single-ingredient vitamin B6 in a coenzyme form, pyridoxal 5’ phosphate. Each vegetarian capsule gives you 34 mg of vitamin B6 (2,000% of the Daily Value) from 50 mg of P5P, and each bottle holds 60 capsules at one a day. B6 helps your body turn food into usable energy, process protein, and make the chemical messengers your nervous system runs on.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis one is for people who want their B6 as one clear number in one capsule, not tucked into a blend, and in the coenzyme form itself. A lot of them are in their 30s and 40s, already paying attention to energy and metabolism so they can still be hiking, lifting and keeping up with the grandkids in their 70s and 80s. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003cp\u003eIt's also a deliberate dose. Most adults need 1.3 to 1.7 mg of B6 a day, according to the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB6-HealthProfessional\/\"\u003eNIH vitamin B6 fact sheet\u003c\/a\u003e, so 34 mg is a high-potency choice you make on purpose, ideally with your practitioner in the loop. If you only want the basics covered, your multivitamin may already do it.\u003c\/p\u003e\n\u003ch2\u003eWhy people take P5P 50 mg\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports energy metabolism, including turning stored glycogen back into usable fuel.†\u003c\/li\u003e\n\u003cli\u003eSupports protein and amino acid metabolism, which is most of what B6 does all day.†\u003c\/li\u003e\n\u003cli\u003eSupports normal nervous system function by helping make neurotransmitters.†\u003c\/li\u003e\n\u003cli\u003eSupports normal red blood cell formation, since B6 helps build hemoglobin.†\u003c\/li\u003e\n\u003cli\u003eSupports normal immune function.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B6 (from 50 mg of pyridoxal 5’ phosphate - the coenzyme form of B6)\u003c\/td\u003e\n\u003ctd\u003e34 mg\u003c\/td\u003e\n\u003ctd\u003e2,000%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 1 Vegetarian Capsule. Each bottle holds 60 vegetarian capsules, a 60-day supply at the label's serving of one capsule a day. Other ingredients: L-Leucine, vegetarian capsule (hypromellose and water), ascorbyl palmitate, silica, and vegetable stearate. The label states: \"NO alcohol, soy, salt, yeast, gluten, milk \u0026amp; egg products, starch, or preservatives.\"\u003c\/p\u003e\n\u003ch2\u003eHow P5P 50 mg works\u003c\/h2\u003e\n\u003ch3\u003eP5P is the form your enzymes plug in\u003c\/h3\u003e\n\u003cp\u003eVitamin B6 is a family of six related compounds, and pyridoxal 5’ phosphate (P5P, also written PLP) is one of its two active coenzyme forms, the ones enzymes actually use, per the NIH. The other forms you eat or swallow have to be converted first. A \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23342087\/\"\u003elab study using human intestinal cells\u003c\/a\u003e found the gut carries the full enzyme set for that conversion and does a real share of the work, not just the liver.\u003c\/p\u003e\n\u003cp\u003eNow the honest part. P5P isn't absorbed whole: the phosphate comes off in your small intestine, the B6 crosses over, and your cells put a phosphate back on. The NIH also notes that absorption doesn't differ much between the B6 forms used in supplements. What P5P changes is the route. Pyridoxine HCl, which the NIH says is the most common B6 form in supplements, needs two enzyme steps to become P5P, including an oxidase that depends on riboflavin (vitamin B2), per the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Riboflavin-HealthProfessional\/\"\u003eNIH riboflavin fact sheet\u003c\/a\u003e. Pyridoxal, which is what P5P turns into as it's absorbed, needs only one. So you're starting with B6 that is already most of the way there.\u003c\/p\u003e\n\u003cp\u003eOnce it's in place, P5P works as a coenzyme in more than 100 enzyme reactions, mostly in protein metabolism. Researchers usually judge B6 status by measuring P5P in blood plasma, and a review of \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25974692\/\"\u003ehow B6 status is measured\u003c\/a\u003e lists P5P-dependent reactions across amino acid metabolism, from the kynurenine pathway to transsulfuration.\u003c\/p\u003e\n\u003ch3\u003eEnergy and protein metabolism\u003c\/h3\u003e\n\u003cp\u003eB6's day job is amino acids. P5P helps move nitrogen-containing groups from one molecule to another so your body can build, break down and repurpose protein. It's also part of how you tap stored fuel: B6 is involved in breaking down glycogen, the glucose your muscles and liver keep in reserve, and in making glucose from scratch between meals. It helps form hemoglobin too, the protein that carries oxygen in red blood cells.†\u003c\/p\u003e\n\u003cp\u003eBeing candid: none of that feels like a cup of coffee. B6 keeps the machinery running; it doesn't floor the gas.\u003c\/p\u003e\n\u003ch3\u003eBrain and nervous system\u003c\/h3\u003e\n\u003cp\u003eYour nervous system uses B6 to make neurotransmitters, the chemical messengers nerve cells use to talk to each other.† The human research here is real but modest. In a \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1365868\/\"\u003e3-month trial in 76 healthy men aged 70 to 79\u003c\/a\u003e, 20 mg a day of pyridoxine HCl showed positive effects only on memory, mostly long-term memory storage, and the authors called the improvement modest. A \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12042457\/\"\u003e5-week trial in 211 healthy women of various ages\u003c\/a\u003e tested folate, B12 or 75 mg of B6 against placebo: supplementation slightly helped some memory scores and had no effect on mood. Neither trial was about P5P specifically, so read them as evidence about B6 in general.\u003c\/p\u003e\n\u003ch3\u003eHomocysteine: what B6 does and doesn't do\u003c\/h3\u003e\n\u003cp\u003eHomocysteine is an amino acid your body makes and recycles. B6 helps keep it at normal levels alongside folate and B12, and P5P is the cofactor for transsulfuration, one of the routes your body uses to clear it.† Here's the less exciting part: in a \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9569395\/\"\u003emeta-analysis of 12 randomized trials with 1,114 people\u003c\/a\u003e, folic acid lowered blood homocysteine by about 25% and B12 added about 7% more, while B6 (averaging 16.5 mg a day) added no significant further drop. So B6 is part of the homocysteine picture, but folate and B12 do most of the lifting.\u003c\/p\u003e\n\u003ch2\u003eHow to take P5P 50 mg\u003c\/h2\u003e\n\u003cp\u003eThe label says: \"Take one capsule daily, as a dietary supplement.\"\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKeep an eye on your total B6.\u003c\/strong\u003e Each capsule gives you 34 mg. The US upper limit for adults is 100 mg a day from food and supplements combined, per the NIH. In 2023, \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37207271\/\"\u003eEurope's food-safety panel set a more cautious adult limit of 12 mg a day\u003c\/a\u003e, based on the well-established link between excess B6 and nerve problems. So add up every B6 source you take, and if you notice numbness or tingling in your hands or feet, stop and talk to your practitioner.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the P5P included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of P5P 50 mg gets its own.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and our UL-certified cGMP facility is right there in it. The people who formulate, make and test P5P 50 mg all work under one roof, and the owners work in the building too (owner-run since 2017), so the people making the decisions are just down the hall.\u003c\/p\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. That's 52 years of doing this, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much vitamin B6 is in each capsule?\u003c\/h3\u003e\n\u003cp\u003eEach capsule has 34 mg of vitamin B6 from 50 mg of pyridoxal 5’ phosphate, 2,000% of the Daily Value, as printed on the Supplement Facts panel.\u003c\/p\u003e\n\u003ch3\u003eDoes P5P absorb more easily than regular B6?\u003c\/h3\u003e\n\u003cp\u003eNot in any way we can honestly promise. The NIH notes absorption doesn't differ much among supplement B6 forms. The real difference is the route: P5P skips the riboflavin-dependent step pyridoxine HCl needs.\u003c\/p\u003e\n\u003ch3\u003eWhen should I take it, and does it need food?\u003c\/h3\u003e\n\u003cp\u003eOne capsule a day, whenever you'll remember it. The label doesn't mention food, so pick the meal or time that's easiest. Keeping the bottle by the coffee maker can help you remember.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with B-Complex or B-12 Essential Trio?\u003c\/h3\u003e\n\u003cp\u003eYes with \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-sublingual-essential-trio\"\u003eB-12 Essential Trio\u003c\/a\u003e, but think twice about B-Complex. Trio adds 4 mg of B6, for 38 mg a day in total. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b-good-com-vitamin-b-complex\"\u003eB-Complex\u003c\/a\u003e already has 100 mg of vitamin B6 per capsule, so taking both puts you at 134 mg a day, over the 100 mg adult upper limit. Pick one, or ask your practitioner. For extra B12 with no added B6, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-dots-energy-nervous-support\"\u003eTriple B-12 Dots\u003c\/a\u003e contain none.\u003c\/p\u003e\n\u003ch3\u003eHow long until I notice anything?\u003c\/h3\u003e\n\u003cp\u003eThere's no set timeline, and you may not feel anything obvious. The trials above ran 5 weeks to 3 months and measured memory scores, not how energetic people felt. If you already get enough B6 from food, the honest answer may be: not much day to day.\u003c\/p\u003e\n\u003ch3\u003eIs it safe to take with my medications?\u003c\/h3\u003e\n\u003cp\u003eAsk your practitioner before you start. Vitamin B6 can interact with certain medications, and some medications can affect your B6 levels, according to the NIH. Bring the bottle to your appointment, or use our \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/tools\/interaction-checker\"\u003esupplement and medication interaction checker\u003c\/a\u003e to prep your questions.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/why-choose-us\"\u003eHow we make and test our supplements\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/tools\/interaction-checker\"\u003eCheck a supplement against your medications\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eAlbersen M et al. The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model. PLoS One. 2013. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23342087\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eUeland PM et al. Direct and Functional Biomarkers of Vitamin B6 Status. Annu Rev Nutr. 2015. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25974692\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDeijen JB et al. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology (Berl). 1992. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1365868\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBryan J et al. Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr. 2002. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12042457\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHomocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BMJ. 1998. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9569395\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eEFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D et al. Scientific opinion on the tolerable upper intake level for vitamin B6. EFSA J. 2023. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37207271\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eNIH Office of Dietary Supplements. Vitamin B6: Fact Sheet for Health Professionals. Updated June 16, 2023. \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB6-HealthProfessional\/\"\u003eNIH ODS\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eNIH Office of Dietary Supplements. Riboflavin: Fact Sheet for Health Professionals. Updated May 11, 2022. \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Riboflavin-HealthProfessional\/\"\u003eNIH ODS\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":50745221710106,"sku":"015-M0249","price":15.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M0249_REV00_NewItemBadge.png?v=1750267129"},{"product_id":"energy-focus-stack-adrenal-b12","title":"Energy \u0026 Focus Stack – Adrenal Support, B-12 Essential Trio \u0026 B-Complex","description":"\u003cp\u003e\u003cstrong\u003eThe Energy \u0026amp; Focus Stack is three bottles: Adrenal Support (an adaptogen blend plus vitamins B5, B6 and C; 60 vegetarian tablets), B-12 Essential Trio (2,000 mcg of methylcobalamin per serving; 2 fl oz liquid) and B-Complex (all eight B vitamins; 60 vegetarian capsules). Together they support normal energy metabolism and a healthy response to occasional stress.† The stack is $60.36, versus $81.97 bought separately, so you save $21.61 (about 26%).\u003c\/strong\u003e\u003c\/p\u003e\r\n\u003cp\u003eThis stack is for the years when the calendar is full and coffee is doing too much of the work: late 30s and 40s, a demanding job, kids or aging parents, a training plan you'd like to keep. Aging isn't optional. Getting old is. The habits you build now are the ones that carry you into your 70s and 80s.\u003c\/p\u003e\r\n\u003ch2\u003eAdrenal Support: adaptogen herbs plus vitamins B5, B6 and C\u003c\/h2\u003e\r\n\u003cp\u003eEach 2-tablet serving of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/adrenal-support-60-vegetarian\"\u003eAdrenal Support, our adaptogen tablet\u003c\/a\u003e has 50 mg of vitamin C (55% DV), 20 mg of vitamin B6 from pyridoxine HCl (1,176% DV) and 500 mg of pantothenic acid from d-calcium pantothenate (10,000% DV), plus a 425 mg proprietary herbal blend: rhodiola root extract (standardized to 1% salidrosides), ashwagandha root extract (standardized to 2.5% withanolides), wild yam root extract, schizandra berry, eleuthero root extract and organic stinging nettle leaf. The bottle holds 30 servings.\u003c\/p\u003e\r\n\u003cp\u003e\"Adaptogen\" is what researchers call herbs studied for helping the body hold its balance under stress. In one 60-day trial, 60 healthy adults who reported high stress took 240 mg of a standardized ashwagandha extract or a placebo daily. The ashwagandha group had a larger drop in morning cortisol, with no side effects reported (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ea 60-day ashwagandha trial in stressed, healthy adults\u003c\/a\u003e).† A systematic review of 11 placebo-controlled rhodiola trials found it may help physical and mental performance with few, mild side effects, though the authors noted that the individual trials hadn't been independently repeated (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21036578\/\"\u003ea systematic review of rhodiola trials\u003c\/a\u003e).† One honest note: the label doesn't list each herb's amount, so we can't say a serving matches those study doses.\u003c\/p\u003e\r\n\u003ch2\u003eB-12 Essential Trio: liquid methylcobalamin, folinate and B6\u003c\/h2\u003e\r\n\u003cp\u003eOne serving of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-sublingual-essential-trio\"\u003eB-12 Essential Trio, our liquid B12\u003c\/a\u003e is one dropper bulb squeeze (about half a dropper, about 0.84 grams): 2,000 mcg of vitamin B12 as methylcobalamin (83,333% DV), 680 mcg DFE of folinate from calcium folinate (170% DV) and 4 mg of vitamin B6 (235% DV). The 2 fl oz bottle holds 80 servings, with natural blueberry flavor.\u003c\/p\u003e\r\n\u003cp\u003eWhy these forms: methylcobalamin is one of the two forms of B12 your cells use directly; cyanocobalamin gets converted first (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e). Folinate is already in the reduced folate family, so it skips the conversion step folic acid needs. B12, folate and B6 work as a team in the cycle that supplies methyl groups to your cells.†\u003c\/p\u003e\r\n\u003ch2\u003eB-Complex: all eight B vitamins in one capsule\u003c\/h2\u003e\r\n\u003cp\u003eOne capsule of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b-good-com-vitamin-b-complex\"\u003eB-Complex, our one-a-day B vitamin capsule\u003c\/a\u003e has 100 mg each of thiamin, riboflavin, vitamin B6 and pantothenic acid, niacinamide (100 mg NE), 680 mcg DFE of folic acid, 100 mcg of vitamin B12 (cyanocobalamin) and 100 mcg of biotin, plus 47 mg of choline, 100 mg of inositol and 60 mg of PABA. The bottle holds 60 capsules, a 60-day supply at the label's one capsule a day.\u003c\/p\u003e\r\n\u003cp\u003eB vitamins don't supply calories. They're coenzymes, helpers your enzymes need to pull energy out of food and to make DNA and brain chemical messengers. A review of all eight shows how closely their jobs overlap, which is the author's case for taking the whole group (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003ea review of how the eight B vitamins work together\u003c\/a\u003e).†\u003c\/p\u003e\r\n\u003ch2\u003eHow to take them together\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eAdrenal Support:\u003c\/strong\u003e \"One to two tablets, as a dietary supplement.\" The amounts above are for 2 tablets.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eB-12 Essential Trio:\u003c\/strong\u003e \"Take one serving by mouth in the morning.\" Refrigerate after opening.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eB-Complex:\u003c\/strong\u003e \"One capsule daily, as a dietary supplement.\"\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003eMind the vitamin B6: at full label servings the three bottles add up to 124 mg a day (20 + 4 + 100), above the 100 mg daily upper limit for adults from food and supplements combined (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB6-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B6\u003c\/a\u003e). Check with your practitioner before taking all three at full servings. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\r\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e See the \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/b12-sublingual-essential-trio\"\u003ecertificates of analysis for B-12 Essential Trio\u003c\/a\u003e.\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and all three formulas are made and tested in our UL-certified cGMP facility there, with the formulators, the makers and the testers under one roof. The owners work in the building too; it's been owner-run since 2017. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\r\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\r\n\u003ch3\u003eDoes the Energy \u0026amp; Focus Stack contain caffeine?\u003c\/h3\u003e\r\n\u003cp\u003eNo. None of the three labels lists caffeine. The energy side of this stack comes from B vitamins, which help your body use the food you eat.†\u003c\/p\u003e\r\n\u003ch3\u003eWhy are there two kinds of B12 and folate?\u003c\/h3\u003e\r\n\u003cp\u003eEach bottle is built to stand on its own: the Trio uses methylcobalamin and folinate, and B-Complex uses cyanocobalamin and folic acid. Together that's 2,100 mcg of B12, and no upper limit has been set for B12 because of its low potential for toxicity (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e).\u003c\/p\u003e\r\n\u003ch3\u003eHow long does the stack last?\u003c\/h3\u003e\r\n\u003cp\u003eThe bottles run out at different times. Adrenal Support holds 30 servings of 2 tablets, B-12 Essential Trio holds 80 servings, and B-Complex is a 60-day supply at one capsule a day.\u003c\/p\u003e\r\n\u003ch3\u003eIs the stack safe with my medication?\u003c\/h3\u003e\r\n\u003cp\u003eAsk your healthcare practitioner, and bring all three bottles. Herbs aren't harmless just because they're plants. You can also check combinations in our \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/tools\/interaction-checker\"\u003esupplement and medication interaction checker\u003c\/a\u003e.\u003c\/p\u003e\r\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/single-bottle-solution-what-is-it-and-why-do-we-put-it-on-our-premium-bottles\"\u003eWhat \"Single Bottle Solution\" on our labels means\u003c\/a\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch2\u003eReferences\u003c\/h2\u003e\r\n\u003col\u003e\r\n\u003cli\u003eLopresti AL et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eHung SK et al. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21036578\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eKennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":50897017176346,"sku":"BundleM1000M2210A2207","price":60.36,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/Bundle_Group_Image.png?v=1753454087"},{"product_id":"mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules","title":"Urolithin A 500 mg – Mitochondrial Renewal \u0026 Cellular Energy | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eMt. Angel Vitamins Urolithin A gives you 500 mg of urolithin A in a single capsule, with 60 capsules per bottle: a 60-day supply at the label's one capsule a day. Urolithin A is a compound some people's gut bacteria make from plant tannins in pomegranates, walnuts and berries. It supports mitophagy, the way your cells recycle worn-out mitochondria, for cellular energy, muscle strength and healthy aging.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAging isn't optional. Getting old is. Urolithin A is for people who want their muscles and their energy to keep up for the long haul: people in their late 30s and 40s already planning how they want to feel at 75, and people over 50 who intend to keep going strong. The strength and endurance trials enrolled adults from 40 to 90, so that's where the evidence lives.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Urolithin A\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial renewal.\u003c\/strong\u003e Supports mitophagy, the routine where cells tag worn-out mitochondria, take them apart and recycle the pieces.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular energy.\u003c\/strong\u003e Supports healthy mitochondrial function and cellular energy production.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle strength.\u003c\/strong\u003e In a 4-month trial in sedentary middle-aged adults, 500 mg a day supported leg muscle strength compared with placebo.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial health markers.\u003c\/strong\u003e In healthy older adults, 4 weeks at 500 mg a day shifted blood and muscle markers of mitochondrial health.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealthy aging.\u003c\/strong\u003e Supports the mitochondrial upkeep that tends to slow down as we get older.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eUrolithin A\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*Daily Value not established. Serving size: 1 Capsule. Servings per container: 60. Other ingredients: Cellulose (from capsule shell), brown rice protein, and vegetable stearates. The label states: \"NO soy, salt, yeast, gluten, wheat, milk \u0026amp; egg products, sugar, starch, or preservatives.\" One active ingredient, no proprietary blend.\u003c\/p\u003e\n\u003ch2\u003eHow Urolithin A works\u003c\/h2\u003e\n\u003ch3\u003eWhere urolithin A comes from\u003c\/h3\u003e\n\u003cp\u003eYou don't actually eat urolithin A. Pomegranates, walnuts and some berries contain ellagitannins, and certain gut bacteria convert those into urolithin A, if you carry them. In a study of 100 healthy adults, just 12% had detectable urolithin A in their blood at the start, and about 40% converted a meaningful amount after a glass of pomegranate juice. A 500 mg serving of urolithin A delivered more than six times the exposure of the juice (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34117375\/\"\u003eSingh et al., 2021\u003c\/a\u003e). Taking the finished compound means the same amount every day, no matter who lives in your gut.\u003c\/p\u003e\n\u003ch3\u003eMitophagy, in plain English\u003c\/h3\u003e\n\u003cp\u003eMitochondria are the parts of your cells that turn food and oxygen into usable energy. They wear out. A worn mitochondrion makes less energy and more junk, so healthy cells tag the damaged ones, break them down and recycle the parts so replacements can be built. That cleanup is called mitophagy, and it tends to slow down as we get older, right about when you'd want it running well. Urolithin A supports that recycling process.†\u003c\/p\u003e\n\u003cp\u003eThe human evidence for the mechanism comes from muscle, because muscle is packed with mitochondria and easy to sample. In the first human study, 4 weeks at 500 mg or 1,000 mg a day shifted blood and muscle markers of mitochondrial health in healthy, sedentary older adults (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32694802\/\"\u003eAndreux et al., 2019\u003c\/a\u003e). In a 4-month trial, the 500 mg daily dose raised the active form of Parkin, one of the proteins that marks a mitochondrion for recycling, in muscle samples (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). It doesn't add energy from the outside; it supports maintenance your cells already do.†\u003c\/p\u003e\n\u003ch3\u003eWhat the human trials found\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eStrength in middle age.\u003c\/strong\u003e In a 4-month randomized, placebo-controlled trial, 88 sedentary adults aged 40 to 64 took 500 mg, 1,000 mg or placebo daily. Average hamstring strength improved about 12% in the 500 mg group and 9.8% in the 1,000 mg group, both significant compared with placebo, while the placebo group's strength dropped. The trial's main goal, peak power output on a bike, did not differ from placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEndurance after 65.\u003c\/strong\u003e In a 4-month trial in 66 adults aged 65 to 90, half took 1,000 mg a day and half took placebo. Endurance in a hand muscle and a leg muscle (contractions until fatigue) improved with urolithin A compared with placebo at 2 months. The trial's two main goals, 6-minute walk distance and peak muscle energy production, did not differ from placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\"\u003eLiu et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eWhat the research doesn't show\u003c\/h3\u003e\n\u003cp\u003ePlenty, and you should know it. In a 4-week trial in 42 highly trained male distance runners, 1,000 mg a day did not improve 3,000 m time-trial results, though effort ratings and a blood marker of muscle damage after the time trial were lower than with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40839339\/\"\u003eWhitfield et al., 2025\u003c\/a\u003e). If you're 28 and already training hard, this probably isn't your first purchase. The longest trials cited here ran 4 months, so they can't tell you what years of use look like. Every study cited here had co-authors from the company that developed the ingredient they tested. And none of them tested this exact bottle: they tested urolithin A itself at 500 mg and 1,000 mg a day.\u003c\/p\u003e\n\u003ch3\u003eWhy 500 mg in one capsule\u003c\/h3\u003e\n\u003cp\u003e500 mg is the lower of the two daily amounts in the 4-month middle-aged trial, and that group's hamstring strength gain (about 12%) was in the same range as the 1,000 mg group's (9.8%). One honest caveat: the trial in adults over 65 used only 1,000 mg.\u003c\/p\u003e\n\u003ch2\u003eHow to take Urolithin A\u003c\/h2\u003e\n\u003cp\u003eLabel directions: \"Take 1 capsule daily, as a dietary supplement.\"\u003c\/p\u003e\n\u003cp\u003eIn the middle-aged trial, people took urolithin A in the morning before breakfast with water (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). No study has compared timing or food, so pick the time you'll stick with.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, urolithin A included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eSee the certificates of analysis for this product\u003c\/a\u003e and match one to the lot number on your bottle.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon, with globally sourced ingredients.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and our UL-certified cGMP facility sits right in it. The people who formulate, make and test this capsule work under one roof, and the owners work in the building too. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much urolithin A is in each capsule?\u003c\/h3\u003e\n\u003cp\u003eEach capsule contains 500 mg of urolithin A, and the label serving is one capsule a day. With 60 capsules in the bottle, that's a 60-day supply.\u003c\/p\u003e\n\u003ch3\u003eWhen should I take it, and does it need food?\u003c\/h3\u003e\n\u003cp\u003eTake one capsule a day at whatever time you'll remember. The label doesn't name a time, and no study has compared timing or food.\u003c\/p\u003e\n\u003ch3\u003eHow long until I notice something?\u003c\/h3\u003e\n\u003cp\u003eThink months, not days. Urolithin A isn't a stimulant, so there's no jolt to feel. The trials measured muscle endurance at 2 months and strength at 4 months, so give it two to four months of daily use before you judge it.†\u003c\/p\u003e\n\u003ch3\u003eCan't I just eat more pomegranates?\u003c\/h3\u003e\n\u003cp\u003eEat them anyway, but they may not get you much urolithin A. Pomegranates contain the raw material, not urolithin A itself, and only some people's gut bacteria convert it well. A 500 mg serving of urolithin A gave more than six times the exposure of a glass of pomegranate juice (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34117375\/\"\u003eSingh et al., 2021\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eCan I take it with NMN + NR or CoQ10?\u003c\/h3\u003e\n\u003cp\u003eWe haven't found a published trial that tested urolithin A together with NMN, NR or CoQ10, so we can't promise the combination adds up to more. People pair them because they work on different parts of the same system: urolithin A supports recycling worn-out mitochondria, NMN and NR are building blocks for NAD+, which mitochondria use to make energy, and CoQ10 works inside the energy-making chain itself.† Taking medication? Check with your practitioner before combining supplements.\u003c\/p\u003e\n\u003ch3\u003eIs it safe to take with my medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first. The middle-aged trial excluded people taking statins, blood thinners, steroids or thyroid medication, so there is no trial data for those combinations. In the two 4-month trials, adverse events with urolithin A were similar to placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\"\u003eLiu et al., 2022\u003c\/a\u003e; \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eIs urolithin A a probiotic?\u003c\/h3\u003e\n\u003cp\u003eNo. It's often called a postbiotic: a compound that gut bacteria make, rather than the bacteria themselves. This capsule contains urolithin A, not live cultures.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/urolithin-a\"\u003eUrolithin A ingredient guide: where it comes from, what the trials measured, and safety\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness, for the NAD+ side of cellular energy\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/coq10-alpha-lipoic-acid\"\u003eCoQ10 + Alpha Lipoic Acid, for the energy-making chain inside mitochondria\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack Starter: one bottle each of Urolithin A and NMN + NR\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eAndreux PA et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32694802\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSingh A et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. European Journal of Clinical Nutrition. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34117375\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLiu S et al. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Network Open. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWhitfield J et al. Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. Sports Medicine. 2025. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40839339\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":51859753042202,"sku":"015-M3200","price":89.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M3200REV02_ListingImage1.png?v=1774269533"},{"product_id":"mitochondria-stack-starter","title":"Mitochondria Stack Starter – Cellular Energy Support | 1 Bottle Each","description":"\u003cp\u003e\u003cstrong\u003eThe Mitochondria Stack Starter is one 60-capsule bottle of Urolithin A (500 mg per 1-capsule serving) and one 60-capsule bottle of NMN + NR Cellular Wellness (500 mg NMN and 200 mg nicotinamide riboside per 2-capsule serving, with resveratrol, TMG, Bioperine® and zinc). Urolithin A supports mitochondrial renewal, and NMN + NR supports healthy NAD+ levels for cellular energy.† Bundle price: $129.99, versus $149.98 bought separately, so you save $19.99.\u003c\/strong\u003e\u003c\/p\u003e\r\n\u003cp\u003eYour cells run on mitochondria, and keeping them working takes two jobs: clearing out the worn-out ones, and keeping the rest supplied with NAD+, a coenzyme they need to turn food into usable energy. This stack puts one product on each job.† It's built for people in their late 30s and 40s who are already working on energy and cellular health, and for anyone past 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\r\n\u003ch2\u003eUrolithin A: the cleanup crew\u003c\/h2\u003e\r\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A\u003c\/a\u003e is a single-ingredient formula: 500 mg of urolithin A in each 1-capsule serving, 60 servings per bottle. The label says it supports mitochondrial renewal, cellular energy, and promotes healthy aging.†\u003c\/p\u003e\r\n\u003cp\u003eYour gut bacteria make urolithin A from ellagitannins, the polyphenols in pomegranates, walnuts and some berries, and how much you make varies a lot from person to person: in one trial, only about 15% of participants had any in their blood at the start (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). Taking it directly skips that step. In research, it's mainly studied for supporting mitophagy, the process cells use to tag worn-out mitochondria and recycle them so healthier ones carry the load.†\u003c\/p\u003e\r\n\u003cp\u003eIn a 4-month randomized trial in 88 untrained middle-aged adults taking 500 mg or 1,000 mg daily, hamstring strength rose about 12% at 500 mg (about 10% at 1,000 mg) compared with placebo, and muscle samples showed more of the proteins tied to mitophagy and mitochondrial metabolism. The trial's main measure, peak power output, did not improve significantly, and the study was run by the developer of the urolithin A it tested (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\r\n\u003ch2\u003eNMN + NR Cellular Wellness: the fuel line\u003c\/h2\u003e\r\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness\u003c\/a\u003e comes as 60 capsules, 30 servings of 2 capsules. Each serving contains:\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003eβ-Nicotinamide Mononucleotide: 500 mg\u003c\/li\u003e\r\n\u003cli\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root): 250 mg\u003c\/li\u003e\r\n\u003cli\u003eNicotinamide riboside: 200 mg\u003c\/li\u003e\r\n\u003cli\u003eTrimethylglycine (TMG) (Betaine anhydrous): 50 mg\u003c\/li\u003e\r\n\u003cli\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit): 50 mg\u003c\/li\u003e\r\n\u003cli\u003eZinc (as bisglycinate chelate): 10 mg\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003eNMN and NR are vitamin B3 compounds that your body turns into NAD+. Mitochondria use NAD+ to make energy, and enzymes called sirtuins depend on it too. NR is converted into NMN, and NMN becomes NAD+ in one more step, so the formula covers both entry points. The label says it supports cellular energy production and maintains healthy NAD+ levels.†\u003c\/p\u003e\r\n\u003cp\u003eThe supporting cast: resveratrol from Japanese knotweed root (\u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e), TMG (betaine, a methyl donor), Bioperine® from black pepper fruit (\u003cem\u003ePiper nigrum\u003c\/em\u003e), and zinc as a bisglycinate chelate (zinc bound to glycine).\u003c\/p\u003e\r\n\u003cp\u003eIn a 60-day randomized trial in 80 healthy middle-aged adults, NMN at 300, 600 or 900 mg once daily raised blood NAD+ in every dose group, was well tolerated, and increased six-minute walking distance more than placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003eYi et al., 2022\u003c\/a\u003e). In a small 6-week crossover trial in 30 healthy adults aged 55 to 79, NR at 1,000 mg a day (one serving here has 200 mg) was well tolerated and raised NAD+ in blood cells by about 60% compared with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003eMartens et al., 2018\u003c\/a\u003e). Each trial tested one ingredient alone, not this formula or this stack.\u003c\/p\u003e\r\n\u003ch2\u003eHow to take them together\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eUrolithin A:\u003c\/strong\u003e Take 1 capsule daily, as a dietary supplement.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eNMN + NR Cellular Wellness:\u003c\/strong\u003e Take 2 capsules daily, as a dietary supplement (a 30-day supply per bottle).\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003eNeither product's directions name a time of day or mention food.\u003c\/p\u003e\r\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\r\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003ethe certificates of analysis for Urolithin A\u003c\/a\u003e and \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003ethe certificates of analysis for NMN + NR Cellular Wellness\u003c\/a\u003e.\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e Both bottles come out of our UL-certified cGMP facility in a Willamette Valley farm town of about 3,500, where formulators, makers and testers work under one roof and the owners work in the building too. We've been making supplements in Oregon since 1974, and we're not getting old either.\u003c\/p\u003e\r\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\r\n\u003ch3\u003eWhat's the difference between urolithin A and NMN?\u003c\/h3\u003e\r\n\u003cp\u003eThey work on different parts of the same system. Urolithin A supports mitophagy, the recycling of worn-out mitochondria, while NMN and NR are building blocks for NAD+, the coenzyme mitochondria use to make energy.† See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/urolithin-a-vs-nmn\"\u003ehow urolithin A and NMN differ\u003c\/a\u003e.\u003c\/p\u003e\r\n\u003ch3\u003eWhy buy the stack instead of the two bottles separately?\u003c\/h3\u003e\r\n\u003cp\u003eThe price. The Starter is $129.99, and the same two bottles bought separately come to $149.98, so you save $19.99. They're the same products with the same labels.\u003c\/p\u003e\r\n\u003ch3\u003eHow soon will I notice anything?\u003c\/h3\u003e\r\n\u003cp\u003eThere's no set timeline, and many changes researchers track are measured in a lab, not felt. The trials above ran from 6 weeks to 4 months, so judge it on steady daily use, not one week.\u003c\/p\u003e\r\n\u003ch3\u003eCan I take this stack with medication?\u003c\/h3\u003e\r\n\u003cp\u003eAsk your healthcare practitioner first, and bring both labels along.\u003c\/p\u003e\r\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/urolithin-a-complete-guide\"\u003eThe full guide to urolithin A: dose, trials and safety\u003c\/a\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/nad-longevity-complete-guide\"\u003eHow NAD+ works and what NMN and NR do\u003c\/a\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-double\"\u003eMitochondria Stack Double, 2 bottles of each\u003c\/a\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch2\u003eReferences\u003c\/h2\u003e\r\n\u003col\u003e\r\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":52626906448154,"sku":"MITO-STACK-1M","price":129.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/22ee0c8d4d34e9cd2218d5b90cfc3978.jpg?v=1785694676"},{"product_id":"mitochondria-stack-double","title":"Mitochondria Stack Double – Cellular Energy Support | 2 Bottles Each","description":"\u003cp\u003e\u003cstrong\u003eThe Mitochondria Stack Double is two 60-capsule bottles of Urolithin A (500 mg per 1-capsule serving) and two 60-capsule bottles of NMN + NR Cellular Wellness (500 mg NMN and 200 mg nicotinamide riboside per 2-capsule serving). Urolithin A supports mitochondrial renewal, and NMN + NR supports healthy NAD+ levels for cellular energy.† Bundle price: $249.99, versus $299.96 bought separately, so you save $49.97.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYour mitochondria turn food into energy, and keeping them in shape takes two jobs: recycling the worn-out ones and keeping the rest supplied with NAD+. This stack puts one product on each job.† It's for people in their late 30s and 40s already working on energy and cellular health, and anyone past 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eUrolithin A 500 mg: two bottles for mitochondrial renewal\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A\u003c\/a\u003e is a single-ingredient formula: 500 mg of urolithin A per 1-capsule serving, 60 servings per bottle. The label says it supports mitochondrial renewal, cellular energy, and promotes healthy aging.†\u003c\/p\u003e\n\u003cp\u003eGut bacteria make urolithin A from ellagitannins in pomegranates, berries and walnuts, but not everyone makes much. In one trial, only about 15% of participants had any in their blood at the start (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). Taking it directly skips that step. It's studied mainly for mitophagy, the process cells use to recycle worn-out mitochondria.†\u003c\/p\u003e\n\u003cp\u003eThat trial ran 4 months, the same as two bottles at one capsule a day. In 88 untrained adults aged 40 to 64 with low baseline fitness, 500 mg a day raised hamstring strength about 12% versus placebo, and muscle samples showed more of the proteins tied to mitophagy and mitochondrial metabolism. The main measure, peak power output, did not improve significantly, and most of its authors worked for the company that developed the urolithin A it tested. Dose and safety detail: \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/urolithin-a-complete-guide\"\u003ethe full guide to urolithin A\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eNMN + NR Cellular Wellness: two bottles for NAD+ support\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness\u003c\/a\u003e comes as 60 capsules per bottle, 30 servings of 2 capsules. Each serving contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eβ-Nicotinamide Mononucleotide: 500 mg\u003c\/li\u003e\n\u003cli\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root): 250 mg\u003c\/li\u003e\n\u003cli\u003eNicotinamide riboside: 200 mg\u003c\/li\u003e\n\u003cli\u003eTrimethylglycine (TMG) (Betaine anhydrous): 50 mg\u003c\/li\u003e\n\u003cli\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit): 50 mg\u003c\/li\u003e\n\u003cli\u003eZinc (as bisglycinate chelate): 10 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNMN and NR are vitamin B3 compounds your body turns into NAD+, which mitochondria use to make energy. NR becomes NMN, and NMN becomes NAD+, so the formula covers both entry points. The label says it supports cellular energy production and maintains healthy NAD+ levels.† Rounding it out: resveratrol from Japanese knotweed root, TMG (a methyl donor), black pepper fruit extract, and zinc bound to glycine.\u003c\/p\u003e\n\u003cp\u003eIn a 60-day randomized trial in 80 healthy middle-aged adults, NMN at 300, 600 or 900 mg once daily raised blood NAD+ at every dose, was well tolerated, and increased six-minute walking distance more than placebo, most at 600 and 900 mg (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003eYi et al., 2022\u003c\/a\u003e). In a small 6-week crossover trial in 30 healthy adults aged 55 to 79, NR at 1,000 mg a day (five times one serving here) was well tolerated and raised NAD+ in blood cells about 60% over placebo, with no clear change in aerobic capacity (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003eMartens et al., 2018\u003c\/a\u003e). More on \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/nad-longevity-complete-guide\"\u003ehow NAD+ works and what NMN and NR can and can't do\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eThe honest limits: each trial tested one ingredient on its own, not these formulas and not the two products together, and each had industry involvement, from company-employed authors or study capsules supplied by the ingredient's maker.\u003c\/p\u003e\n\u003ch2\u003eHow to take them together\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrolithin A:\u003c\/strong\u003e Take 1 capsule daily, as a dietary supplement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNMN + NR Cellular Wellness:\u003c\/strong\u003e Take 2 capsules daily, as a dietary supplement.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNeither label names a time of day or mentions food, so pick a time you'll remember. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are rejected.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003ethe certificates of analysis for Urolithin A\u003c\/a\u003e and \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003ethe certificates of analysis for NMN + NR Cellular Wellness\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon.\u003c\/strong\u003e We make and test both products, from globally sourced ingredients, in our UL-certified cGMP facility in this Willamette Valley farm town of about 3,500. Formulators, makers and testers work under one roof, and the owners work in the building too (owner-run since 2017). We've been making supplements in Oregon since 1974, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eWhat's the difference between the Double and the Starter?\u003c\/h3\u003e\n\u003cp\u003eThe Double has twice as much of each product and a bigger discount. The \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack Starter\u003c\/a\u003e is one bottle of each for $129.99, a $19.99 savings. The Double is two of each for $249.99, $49.97 less than buying the four bottles separately.\u003c\/p\u003e\n\u003ch3\u003eHow long does the Double last?\u003c\/h3\u003e\n\u003cp\u003eAt one serving a day, it lasts 120 days for Urolithin A and 60 days for NMN + NR, about the length of the trials above. NMN + NR uses 2 capsules a day to Urolithin A's 1, so it runs out first.\u003c\/p\u003e\n\u003ch3\u003eWhy take urolithin A and NMN together?\u003c\/h3\u003e\n\u003cp\u003eThey support different parts of the same system: urolithin A supports recycling of worn-out mitochondria, and NMN and NR are building blocks for the NAD+ mitochondria use to make energy.† See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/urolithin-a-vs-nmn\"\u003ehow urolithin A and NMN differ\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow soon will I notice anything?\u003c\/h3\u003e\n\u003cp\u003eThere's no set timeline, and many changes researchers track are measured in a lab, not felt. The trials above ran 6 weeks to 4 months, so give it steady daily use over that kind of stretch.\u003c\/p\u003e\n\u003ch3\u003eWhat's not in these capsules?\u003c\/h3\u003e\n\u003cp\u003eEach label prints its own list. Urolithin A: \"NO soy, salt, yeast, gluten, wheat, milk \u0026amp; egg products, sugar, starch, or preservatives.\" NMN + NR: \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\"\u003c\/p\u003e\n\u003ch3\u003eCan I take this stack with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first, and bring both labels along.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":52626906480922,"sku":"MITO-STACK-2M","price":249.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/22ee0c8d4d34e9cd2218d5b90cfc3978_f6209074-002e-4dcc-a7e2-aca2b05e8b8c.jpg?v=1785694687"},{"product_id":"mitochondria-stack-triple","title":"Mitochondria Stack Triple – Cellular Energy Support | 3 Bottles Each","description":"\u003cp\u003e\u003cstrong\u003eThe Mitochondria Stack Triple is three 60-capsule bottles of Urolithin A (500 mg per 1-capsule serving) and three 60-capsule bottles of NMN + NR Cellular Wellness (500 mg NMN and 200 mg nicotinamide riboside per 2-capsule serving, with resveratrol, TMG, Bioperine® and zinc). Urolithin A supports mitochondrial renewal, and NMN + NR supports healthy NAD+ levels for cellular energy.† Bundle price: $349.99, versus $449.94 bought separately, so you save $99.95.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYour cells make most of their energy in mitochondria, and keeping them in shape takes two jobs: recycling the worn-out ones and keeping the rest supplied with NAD+, a coenzyme they need to turn food into energy. This stack puts one product on each job.† The Triple is the long-haul size, built for people in their late 30s and 40s who are working on energy and cellular health so they can thrive in their 70s and 80s, and for anyone past 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eUrolithin A: the recycling crew\u003c\/h2\u003e\n\u003cp\u003eThree bottles of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A\u003c\/a\u003e: 500 mg of urolithin A in each 1-capsule serving, 60 servings per bottle. The label says it supports mitochondrial renewal, cellular energy, and promotes healthy aging.†\u003c\/p\u003e\n\u003cp\u003eGut bacteria make urolithin A from ellagitannins, polyphenols in pomegranates, berries and walnuts, and how much a person makes varies a lot: in one trial, only about 15% of participants had any in their blood at the start (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). Taking it directly skips that step. It's studied mainly for mitophagy, the process cells use to tag worn-out mitochondria and recycle them so healthier ones carry the load.† Dosage, the research and safety are covered in \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/urolithin-a\"\u003ethe urolithin A ingredient guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eIn that 4-month randomized, placebo-controlled trial in 88 untrained adults aged 40 to 64 with low aerobic fitness, average hamstring strength rose about 12% on 500 mg a day (about 10% on 1,000 mg) while it fell in the placebo group, a significant difference, and muscle samples showed more of the proteins tied to mitophagy and mitochondrial metabolism. The limits: the main measure, peak power output, did not improve significantly, and several authors work for the company that makes the urolithin A tested.\u003c\/p\u003e\n\u003ch2\u003eNMN + NR Cellular Wellness: the fuel line\u003c\/h2\u003e\n\u003cp\u003eThree bottles of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness\u003c\/a\u003e, 30 two-capsule servings per bottle. Each serving contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eβ-Nicotinamide Mononucleotide: 500 mg\u003c\/li\u003e\n\u003cli\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root): 250 mg\u003c\/li\u003e\n\u003cli\u003eNicotinamide riboside: 200 mg\u003c\/li\u003e\n\u003cli\u003eTrimethylglycine (TMG) (Betaine anhydrous): 50 mg\u003c\/li\u003e\n\u003cli\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit): 50 mg\u003c\/li\u003e\n\u003cli\u003eZinc (as bisglycinate chelate): 10 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNMN and NR are both built from vitamin B3, and your body turns both into NAD+, which mitochondria use to make energy.† Inside cells, NR becomes NMN and NMN becomes NAD+, and this formula includes both. The label says it supports cellular energy production and maintains healthy NAD+ levels.† Alongside them: resveratrol from Japanese knotweed root, TMG (betaine, a methyl donor), Bioperine® black pepper fruit extract, and zinc as a bisglycinate chelate, meaning zinc bound to the amino acid glycine.\u003c\/p\u003e\n\u003cp\u003eIn a 60-day randomized trial in 80 healthy middle-aged adults, NMN at 300, 600 or 900 mg once daily raised blood NAD+ at every dose, was well tolerated, and increased six-minute walking distance more than placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003eYi et al., 2022\u003c\/a\u003e). In a small 6-week crossover trial in healthy adults aged 55 to 79, NR at 1,000 mg a day was well tolerated and raised NAD+ in blood cells about 60% compared with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003eMartens et al., 2018\u003c\/a\u003e). The limits: each trial tested one ingredient alone, not this formula or this stack, the NR trial used 1,000 mg a day (a serving here has 200 mg), and the NMN trial was co-sponsored by the companies that make the NMN it tested, with a lead author from one of them.\u003c\/p\u003e\n\u003ch2\u003eHow to take them together\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrolithin A:\u003c\/strong\u003e Take 1 capsule daily, as a dietary supplement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNMN + NR Cellular Wellness:\u003c\/strong\u003e Take 2 capsules daily, as a dietary supplement.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThat's 3 capsules a day between the two. Neither label's directions name a time of day or mention food. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003ethe certificates of analysis for Urolithin A\u003c\/a\u003e and \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003ethe certificates of analysis for NMN + NR Cellular Wellness\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA with globally sourced ingredients, in Mt. Angel, Oregon.\u003c\/strong\u003e All six bottles come out of our UL-certified cGMP facility in a Willamette Valley farm town of about 3,500. Formulators, makers and testers work under one roof, and the owners work in the building too. The company has been owner-run since 2017. We've been making supplements in Oregon since 1974, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow long does the Mitochondria Stack Triple last?\u003c\/h3\u003e\n\u003cp\u003e90 days for NMN + NR (each bottle is a 30-day supply) and 180 days for Urolithin A, so you'll still have Urolithin A on hand when the NMN + NR runs out.\u003c\/p\u003e\n\u003ch3\u003eWhy the Triple instead of a smaller size?\u003c\/h3\u003e\n\u003cp\u003eIt costs the least per bottle. The Triple works out to about $116.66 for each pair of bottles, versus about $125 with the \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-double\"\u003eMitochondria Stack Double\u003c\/a\u003e, $129.99 with the \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack Starter\u003c\/a\u003e, and $149.98 bought separately. Same products, same labels.\u003c\/p\u003e\n\u003ch3\u003eWhat's the difference between urolithin A and NMN?\u003c\/h3\u003e\n\u003cp\u003eThey do different jobs in the same system. Urolithin A supports the recycling of worn-out mitochondria, while NMN and NR are building blocks for NAD+.† This stack gives you one of each.\u003c\/p\u003e\n\u003ch3\u003eCan I take both at the same time?\u003c\/h3\u003e\n\u003cp\u003eNothing in either label's directions says to take them separately, so all 3 capsules together is the simplest routine. On medication? Ask your healthcare practitioner first and bring both labels.\u003c\/p\u003e\n\u003ch3\u003eHow soon will I notice anything?\u003c\/h3\u003e\n\u003cp\u003eThere's no set timeline, and most of what researchers track is measured in a lab, not felt. The trials above ran 6 weeks to 4 months, and the Triple gives you 90 days of both.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":52626906513690,"sku":"MITO-STACK-3M","price":349.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/22ee0c8d4d34e9cd2218d5b90cfc3978_60c657a0-58b6-416e-94c4-4aa8242d7429.jpg?v=1785694699"}],"url":"https:\/\/www.mtangelvitamins.com\/collections\/energy-cellular-health-supplements.oembed","provider":"Mt. Angel Vitamins","version":"1.0","type":"link"}