{"title":"New Science","description":"\u003cp\u003eNew science is newer research on how we age, built around mitochondria and cellular energy. Mitochondria make our cells' energy, and NAD+ helps them work; both tend to decline with age. Urolithin A 500 mg supports mitochondrial renewal and cellular energy, and NMN + NR supports healthy NAD+ levels.† We launch new science only when we can test it.\u003c\/p\u003e","products":[{"product_id":"nmn-nr-cellular-wellness-supplement","title":"NMN + NR with Resveratrol and TMG – NAD+ \u0026 Cellular Energy Support | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eNMN + NR with Resveratrol and TMG is a 60-capsule NAD+ formula. Each 2-capsule serving provides 500 mg β-nicotinamide mononucleotide (NMN), 200 mg nicotinamide riboside (NR), 250 mg resveratrol, 50 mg TMG, 50 mg Bioperine® black pepper extract and 10 mg zinc (as bisglycinate chelate), to support cellular energy production and healthy NAD+ levels.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNMN and NR are two building blocks your body uses to make NAD+, which every cell needs for energy and upkeep. This formula puts both in one bottle. It's built for people in their late 30s and 40s who are already working on energy and cellular health, and for anyone over 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take NMN + NR\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealthy NAD+ levels.\u003c\/strong\u003e NMN and NR are both NAD+ precursors, and each raised blood NAD+ in placebo-controlled trials in healthy adults.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular energy.\u003c\/strong\u003e Your mitochondria use NAD+ to turn food into ATP, the energy your cells run on.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNormal DNA repair.\u003c\/strong\u003e PARPs, enzymes involved in routine DNA repair, need NAD+ to work, and so do sirtuins.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant support.\u003c\/strong\u003e Resveratrol is a plant polyphenol studied for its role in the body's normal defenses against everyday oxidative stress.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMethylation and enzyme support.\u003c\/strong\u003e TMG donates methyl groups for normal methylation, and zinc helps hundreds of enzymes work.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eβ-Nicotinamide Mononucleotide\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root)\u003c\/td\u003e\n\u003ctd\u003e250 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide riboside\u003c\/td\u003e\n\u003ctd\u003e200 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTrimethylglycine (TMG) (Betaine anhydrous)\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit)\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (as bisglycinate chelate)\u003c\/td\u003e\n\u003ctd\u003e10 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*Daily Value not established, as printed on the label. Serving size: 2 capsules. Servings per container: 30. Other ingredients: Vegetarian Capsule (Hypromellose and water), organic brown rice and magnesium stearate. The label states: \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\" Bioperine® is a registered trademark of Sabinsa Corporation.\u003c\/p\u003e\n\u003ch2\u003eHow NMN + NR works\u003c\/h2\u003e\n\u003ch3\u003eNMN (β-nicotinamide mononucleotide), 500 mg\u003c\/h3\u003e\n\u003cp\u003eNMN is one step away from NAD+ (nicotinamide adenine dinucleotide), a coenzyme in every cell. Mitochondria use NAD+ to make ATP, and sirtuins and PARPs use it up as they work, so cells keep rebuilding it, and NMN is one of the pieces.† Edamame, broccoli and meat contain it, but only about 1 mg per 100 grams, as the authors of \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35927255\/\"\u003ea 12-week NMN trial in healthy older men\u003c\/a\u003e note.\u003c\/p\u003e\n\u003cp\u003eIn that trial, 42 healthy men aged 65 and older were randomized to 250 mg of NMN or placebo daily, though a supplier mix-up left 12-week results for only 20 of them. NMN raised NAD+ in whole blood and was well tolerated. Gait speed and left-hand grip showed nominal gains the authors say larger studies must confirm, and muscle mass didn't change. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ea 60-day dose-comparison trial in 80 healthy middle-aged adults\u003c\/a\u003e, 300, 600 or 900 mg a day raised blood NAD+ in every group, most at 600 and 900 mg, and six-minute walk distance rose more than with placebo. Several authors work for chemical and biotech companies, so it's worth seeing repeated. On safety, in \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36002548\/\"\u003ea four-week placebo-controlled safety trial in 31 healthy adults\u003c\/a\u003e funded by an NMN maker, 1,250 mg a day produced no changes beyond normal variation.\u003c\/p\u003e\n\u003cp\u003eWhat it doesn't show: these trials ran weeks, not years, higher blood NAD+ isn't proof of a change you'll feel, and we haven't found a trial of this exact combination. Our \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/nad-longevity-complete-guide\"\u003eguide to how NAD+ works and why levels change with age\u003c\/a\u003e goes deeper.\u003c\/p\u003e\n\u003ch3\u003eNR (nicotinamide riboside), 200 mg\u003c\/h3\u003e\n\u003cp\u003eNR is a form of vitamin B3. Inside cells, an enzyme called NRK turns NR into NMN, which then becomes NAD+. NMN can also be converted to NR outside cells and rebuilt inside. So the two are neighbors on the same road, and taking both offers two entry points.†\u003c\/p\u003e\n\u003cp\u003eIn \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ea crossover trial in 30 healthy adults aged 55 to 79\u003c\/a\u003e, 500 mg of NR twice a day for six weeks was well tolerated and raised NAD+ in blood cells by about 60% versus placebo. The 200 mg here is a supporting dose, not a copy of that trial.\u003c\/p\u003e\n\u003ch3\u003eResveratrol, 250 mg from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e root\u003c\/h3\u003e\n\u003cp\u003eResveratrol is a polyphenol best known from grape skins; ours comes from Japanese knotweed (\u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) root. Lab research studies how it interacts with sirtuins, the NAD+-using enzymes above, which is why it's often paired with NAD+ precursors. We haven't found human trials of that pairing, and little of a resveratrol dose reaches the blood intact (low bioavailability).\u003c\/p\u003e\n\u003cp\u003eIn \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24804871\/\"\u003ea small single-dose study of resveratrol with and without piperine\u003c\/a\u003e, 23 adults took placebo, 250 mg of trans-resveratrol, or the same with 20 mg of piperine, on separate days. Thinking-task scores and mood didn't change, though the pair increased blood flow in the front of the brain during tasks. In a separate group of six, piperine didn't raise blood resveratrol. Interesting, early, and one study.\u003c\/p\u003e\n\u003ch3\u003eTMG (trimethylglycine), 50 mg\u003c\/h3\u003e\n\u003cp\u003eTMG, also called betaine, carries three methyl groups and hands them off in a process called methylation.† Why it's here: the body clears some of the nicotinamide left over from NAD+ use by attaching methyl groups to it, and TMG is a methyl donor. That's a sensible rationale, not a tested result. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14652361\/\"\u003ea six-week betaine trial in healthy men and women\u003c\/a\u003e, 1.5 to 6 grams a day lowered fasting homocysteine 12 to 20% versus placebo. A serving here has 50 mg, so we don't claim that effect.\u003c\/p\u003e\n\u003ch3\u003eBioperine® (black pepper fruit extract), 50 mg\u003c\/h3\u003e\n\u003cp\u003eBioperine® is a black pepper extract rich in piperine, which can change how the body absorbs and breaks down some compounds. The resveratrol study above found no rise in blood levels, so we don't promise one.\u003c\/p\u003e\n\u003ch3\u003eZinc (as bisglycinate chelate), 10 mg\u003c\/h3\u003e\n\u003cp\u003eZinc is needed for the activity of hundreds of enzymes and plays a role in making protein and DNA and in normal cell division, per the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Zinc-HealthProfessional\/\"\u003eNIH Office of Dietary Supplements zinc fact sheet\u003c\/a\u003e.† Bisglycinate chelate means the zinc is bound to the amino acid glycine. The adult RDA is 8 mg for women and 11 mg for men, and the adult upper limit from all sources is 40 mg a day.\u003c\/p\u003e\n\u003ch2\u003eHow to take NMN + NR\u003c\/h2\u003e\n\u003cp\u003eDirections: Take 2 capsules daily, as a dietary supplement. That one 2-capsule serving a day makes each 60-capsule bottle a 30-day supply.\u003c\/p\u003e\n\u003cp\u003eIf you take other zinc, as in a multivitamin, add up your daily total and keep it under the 40 mg adult upper limit.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are rejected.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003eSee the certificates of analysis for this product\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and we make and test this formula there in our UL-certified cGMP facility. Formulators, makers and testers work under one roof, and the owners work in the building too (owner-run since 2017). We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much NMN and NR is in each serving?\u003c\/h3\u003e\n\u003cp\u003eEach 2-capsule serving has 500 mg of NMN and 200 mg of NR, plus 250 mg of resveratrol, 50 mg of TMG, 50 mg of Bioperine® and 10 mg of zinc. Trials in healthy adults have used up to 900 mg of NMN a day for 60 days and 1,250 mg a day for four weeks without safety problems, though longer-term data at these amounts are limited.\u003c\/p\u003e\n\u003ch3\u003eWhy combine NMN and NR?\u003c\/h3\u003e\n\u003cp\u003eIt gives your body two entry points into the same NAD+ pathway.† We haven't found a trial comparing the pair with an equal amount of either one alone, so it's a reasonable design, not a proven advantage. Here's \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/nmn-vs-nicotinamide-riboside\"\u003ehow NMN and NR differ\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow long before I notice anything?\u003c\/h3\u003e\n\u003cp\u003eNo one can promise a timeline. Blood NAD+ was already higher at the 30-day check in one trial, but NAD+ isn't something you feel like coffee, and most trials above ran 6 to 12 weeks.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with Urolithin A?\u003c\/h3\u003e\n\u003cp\u003eYes. Our \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack\u003c\/a\u003e pairs one bottle each of NMN + NR and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A 500 mg\u003c\/a\u003e. Urolithin A is studied for how cells recycle worn-out mitochondria, while NMN and NR supply NAD+ building blocks.†\u003c\/p\u003e\n\u003ch3\u003eIs it safe with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner before combining it with medication. Piperine, the main compound in Bioperine®, can change how the body absorbs and processes some compounds, and NAD+ precursors haven't been studied alongside most prescriptions.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/nmn-nicotinamide-mononucleotide\"\u003eWhat the human research says about NMN, dose by dose\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/urolithin-a-vs-nmn\"\u003eHow urolithin A and NMN work differently, and which to start with\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eIgarashi M et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35927255\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eFukamizu Y et al. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Sci Rep. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36002548\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWightman EL et al. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr. 2014. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24804871\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eOlthof MR et al. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14652361\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":50096171581722,"sku":"015-M1026","price":59.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M1026_REV01_New_Item.png?v=1738258899"},{"product_id":"cortiresponse-stress-mood-support","title":"CortiResponse – Daily Stress, Mood \u0026 Mental Clarity Support | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eCortiResponse is a 60-capsule formula for daily stress, mood and mental clarity support.† Each 2-capsule serving combines 100 mg of L-theanine, 100 mg of ashwagandha root, 180 mg of holy basil 10:1 extract, 100 mg of passionflower 4:1 extract and 300 mg of magnolia bark 4:1 extract with green tea, cocoa and 120 mcg of chromium. It's made to support a healthy response to occasional stress.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStress doesn't book an appointment. In your 30s and 40s it's deadlines, kids, aging parents and a phone that won't stop buzzing, and the habits you build now carry into the decades ahead. CortiResponse is one simple daily step for staying steady and clear-headed, alongside sleep, food and movement.† Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take CortiResponse\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eTo support a healthy cortisol response to occasional, everyday stress, with ashwagandha, holy basil and magnolia bark.†\u003c\/li\u003e\n\u003cli\u003eTo support calm, relaxed alertness, with 100 mg of L-theanine.†\u003c\/li\u003e\n\u003cli\u003eTo support a positive mood and ease occasional tension, with passionflower and magnolia bark.†\u003c\/li\u003e\n\u003cli\u003eTo support mental clarity and focus on demanding days.†\u003c\/li\u003e\n\u003cli\u003eTo support normal carbohydrate metabolism, with 120 mcg of chromium.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChromium (chromium polynicotinate, GTF)\u003c\/td\u003e\n\u003ctd\u003e120 mcg\u003c\/td\u003e\n\u003ctd\u003e342%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCocoa Seed Extract (\u003cem\u003eTheobroma cacao\u003c\/em\u003e) (standardized to 6% theobromine)\u003c\/td\u003e\n\u003ctd\u003e300 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnolia Bark 4:1 Extract (\u003cem\u003eMagnolia officinalis\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e300 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGreen Tea Leaf Extract (\u003cem\u003eCamilla sinensis\u003c\/em\u003e) (standardized to 50% polyphenols and 35% catechins)\u003c\/td\u003e\n\u003ctd\u003e200 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHoly Basil Herb 10:1 Extract (\u003cem\u003eOcimum sanctum\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e180 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAshwagandha Root (\u003cem\u003eWithania somnifera\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePassionflower Herb (\u003cem\u003ePassiflora incarnata\u003c\/em\u003e) 4:1 Extract\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eL-Theanine\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBanaba Leaf Standardized Extract (\u003cem\u003eLagerstroemia speciosa\u003c\/em\u003e) (standardized to 1% corosolic acid)\u003c\/td\u003e\n\u003ctd\u003e10 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e* Daily Value not established. Serving size: 2 vegetarian capsules. Servings per container: 30. Each bottle holds 60 capsules. Other ingredients: Cellulose (from capsule shell), cellulose, vegetable stearate, and silicon dioxide. The bottle's side panel carries Gluten-Free, Dairy-Free, Soy-Free and Made in the USA icons.\u003c\/p\u003e\n\u003ch2\u003eHow CortiResponse works\u003c\/h2\u003e\n\u003cp\u003eStress tells your adrenal glands to release cortisol through what researchers call the HPA (hypothalamic-pituitary-adrenal) axis. The goal is a response that rises when you need it and settles when you don't, and several ingredients below were studied for that.† Many studies used branded extracts, often at higher amounts than one serving.\u003c\/p\u003e\n\u003ch3\u003eL-theanine, 100 mg\u003c\/h3\u003e\n\u003cp\u003eL-theanine is an amino acid from tea leaves. In a crossover trial in healthy, moderately stressed adults, a single 200 mg dose produced a larger rise in alpha brain waves (the pattern linked with relaxed alertness) than placebo three hours later, and a larger drop in salivary cortisol at one hour (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34562208\/\"\u003ea single-dose L-theanine trial during a mental stress test\u003c\/a\u003e). In a four-week crossover trial, 30 healthy adults (average age 48) took 200 mg a day in one period and a placebo in another. Stress-symptom and sleep-quality scores improved during the L-theanine weeks (some sleep scores beat placebo outright), as did verbal fluency and executive function (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31623400\/\"\u003ea four-week L-theanine trial in healthy adults\u003c\/a\u003e). Both studies were small and used twice the amount in one serving.†\u003c\/p\u003e\n\u003ch3\u003eAshwagandha root, 100 mg\u003c\/h3\u003e\n\u003cp\u003eAshwagandha (\u003cem\u003eWithania somnifera\u003c\/em\u003e) is a root from Ayurvedic tradition and one of the most researched herbs scientists call adaptogens. In a 60-day trial, 60 healthy adults with high self-reported stress took 240 mg of a standardized extract or a placebo daily. The ashwagandha group had a larger drop in morning cortisol, with no side effects reported (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ea 60-day ashwagandha trial in stressed, healthy adults\u003c\/a\u003e). The candid part: CortiResponse has 100 mg of ashwagandha root, not a concentrated extract, so it plays a supporting role.†\u003c\/p\u003e\n\u003ch3\u003eHoly basil 10:1 extract, 180 mg\u003c\/h3\u003e\n\u003cp\u003eHoly basil, or tulsi (\u003cem\u003eOcimum sanctum\u003c\/em\u003e, also called \u003cem\u003eOcimum tenuiflorum\u003c\/em\u003e), is a cousin of kitchen basil. A 10:1 extract is concentrated from about 10 parts herb to 1 part extract. In an 8-week trial, 100 stressed adults aged 18 to 65 took 125 mg of a standardized holy basil extract twice a day or a placebo. The holy basil group saw bigger improvements in perceived stress and sleep-quality scores, lower hair cortisol at week 8, and lower salivary cortisol after a lab stress test (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36185698\/\"\u003ean 8-week holy basil trial in stressed adults\u003c\/a\u003e). That was a different extract than ours, so read it as evidence for the herb, not this capsule.†\u003c\/p\u003e\n\u003ch3\u003eMagnolia bark 4:1 extract, 300 mg\u003c\/h3\u003e\n\u003cp\u003eMagnolia bark (\u003cem\u003eMagnolia officinalis\u003c\/em\u003e) is a staple of traditional Chinese herbal practice. Most human research pairs it with a second bark, phellodendron. In a 4-week trial, 56 moderately stressed adults took that combination or a placebo. The combination group's salivary cortisol exposure was 18% lower than placebo, and their mood-state scores, including tension and fatigue, were better (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23924268\/\"\u003ea 4-week magnolia and phellodendron trial\u003c\/a\u003e). CortiResponse has no phellodendron, so that study speaks to the pairing, not magnolia alone.†\u003c\/p\u003e\n\u003ch3\u003ePassionflower 4:1 extract, 100 mg\u003c\/h3\u003e\n\u003cp\u003ePassionflower (\u003cem\u003ePassiflora incarnata\u003c\/em\u003e) is a climbing vine with a long folk history as a calming herb. The 100 mg of 4:1 extract comes from about 400 mg of the dried herb. Most human passionflower trials took place in medical settings, not everyday stress, so we don't cite them here.†\u003c\/p\u003e\n\u003ch3\u003eGreen tea leaf and cocoa seed extracts\u003c\/h3\u003e\n\u003cp\u003eThe green tea leaf extract (200 mg) is standardized to 50% polyphenols and 35% catechins, about 100 mg of polyphenols and 70 mg of catechins per serving. Catechins such as EGCG are green tea's best-known antioxidants. The cocoa seed extract (300 mg) is standardized to 6% theobromine, about 18 mg per serving. Theobromine is cocoa's gentler cousin of caffeine.†\u003c\/p\u003e\n\u003ch3\u003eChromium and banaba leaf\u003c\/h3\u003e\n\u003cp\u003eChromium is a trace mineral that might help insulin do its job, and it may play a role in carbohydrate, fat and protein metabolism (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Chromium-HealthProfessional\/\"\u003eNIH fact sheet on chromium\u003c\/a\u003e). Ours is chromium polynicotinate (chromium bound to niacin), sometimes labeled GTF. No upper limit has been set for chromium. Banaba leaf extract adds 10 mg. Most human banaba research involves people whose blood sugar is outside the normal range, so we don't cite it here.†\u003c\/p\u003e\n\u003ch2\u003eHow to take CortiResponse\u003c\/h2\u003e\n\u003cp\u003eThe label says: \"Take one to two capsules, 30 minutes before a meal, as a dietary supplement.\" The amounts in the table are for a 2-capsule serving.\u003c\/p\u003e\n\u003cp\u003eThe label warns: \"Not recommended while pregnant or lactating unless directed by a health care practitioner.\" Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. Ashwagandha has been well tolerated in trials lasting up to about three months, and its long-term safety isn't known (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Ashwagandha-HealthProfessional\/\"\u003eNIH fact sheet on ashwagandha\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of CortiResponse gets its own.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley. Our UL-certified cGMP facility keeps the formulators, the makers and the testers under one roof, and the owners (it's been owner-run since 2017) work in the building. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow many CortiResponse capsules should I take?\u003c\/h3\u003e\n\u003cp\u003eOne to two capsules, 30 minutes before a meal, per the label. The Supplement Facts amounts are for 2 capsules.\u003c\/p\u003e\n\u003ch3\u003eDoes CortiResponse contain caffeine?\u003c\/h3\u003e\n\u003cp\u003eThe label doesn't list caffeine. It does contain green tea leaf extract, which can carry some naturally occurring caffeine, and cocoa seed extract, which supplies about 18 mg of theobromine per serving. Sensitive to stimulants? Start with one capsule.\u003c\/p\u003e\n\u003ch3\u003eWill CortiResponse make me drowsy?\u003c\/h3\u003e\n\u003cp\u003eIt isn't made as a sleep formula: there's no melatonin on the label, and the L-theanine research focuses on calm alertness. The NIH lists mild drowsiness as a possible ashwagandha side effect, so notice how you feel at first.\u003c\/p\u003e\n\u003ch3\u003eHow long does it take to notice CortiResponse?\u003c\/h3\u003e\n\u003cp\u003eIt depends on the ingredient. The L-theanine trial measured changes within hours of one dose, while the ashwagandha and holy basil trials ran 60 days and 8 weeks.\u003c\/p\u003e\n\u003ch3\u003eCan I take CortiResponse with your other products?\u003c\/h3\u003e\n\u003cp\u003eYes, but check for shared ingredients first. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/relaxation-supplement-passion-fl\"\u003eRelaxing Passion Flower lozenges\u003c\/a\u003e (50 mg of passionflower 4:1 extract each) and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/natural-sleep-aid-herbal-support\"\u003eSleepy Sleep\u003c\/a\u003e both contain passionflower. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/adrenal-support-60-vegetarian\"\u003eAdrenal Support\u003c\/a\u003e also has ashwagandha, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/good-magnesium-chelate-amino-acids\"\u003eGood Magnesium\u003c\/a\u003e lists holy basil in its other ingredients, and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/brain-advantage\"\u003eBrain Advantage\u003c\/a\u003e has 30 mg of L-theanine. If you stack, run the combination by your practitioner.\u003c\/p\u003e\n\u003ch3\u003eCan I take CortiResponse with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first. Per the NIH fact sheets, ashwagandha might interact with thyroid hormone, blood sugar, blood pressure, immune-suppressing and sedative medications, and chromium might add to the effect of blood sugar medications or reduce levothyroxine absorption.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/single-bottle-solution-what-is-it-and-why-do-we-put-it-on-our-premium-bottles\"\u003eWhat \"Single Bottle Solution\" on our labels means\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eEvans M et al. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population. Neurology and Therapy. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34562208\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHidese S et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31623400\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLopresti AL et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLopresti AL et al. A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer™) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36185698\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eTalbott SM et al. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition. 2013. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23924268\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":50951720304922,"sku":"015-A6001","price":33.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/A6001_REV00_NewItemBadge.png?v=1755025348"},{"product_id":"brain-advantage","title":"Brain Advantage – Brain Energy, Focus \u0026 Recall Support | 60 Vegetarian Capsules","description":"\u003cp\u003e\u003cstrong\u003eBrain Advantage is a two-capsule daily nootropic with 250 mg of Cognizin® citicoline, 320 mg of Synapsa™ bacopa extract standardized to 55% bacosides, and 500 mg of lion's mane extract, plus ginkgo, L-theanine, methylfolate, niacinamide, vitamin C, magnesium and zinc. Each bottle holds 60 vegetarian capsules, a 30-day supply. It supports brain energy, mental focus and recall.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBrain Advantage is for people who would like their memory to keep up with their calendar. Maybe you're 42 and juggling a team and a household. Maybe you're 60 and have big plans for your 80s. Either way, the time to look after your brain is before you're worried about it, which for most people means starting in your 30s and 40s. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003cp\u003eThere's no caffeine in it and nothing designed to give you a buzz. Citicoline and bacopa, the two headline ingredients, both have placebo-controlled research in healthy adults, and both are here as named, branded ingredients with every amount printed. No proprietary blend, no guessing.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Brain Advantage\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBrain energy.\u003c\/strong\u003e Citicoline supplies choline and cytidine, raw materials brain cells use to build their membranes, and it is studied for its role in brain energy metabolism.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFocus and attention.\u003c\/strong\u003e Brain Advantage supports mental focus, and bacopa supports attention and processing speed with consistent daily use.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMemory and recall.\u003c\/strong\u003e Bacopa supports learning and the retention of newly learned information with steady daily use.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEveryday nutrient support.\u003c\/strong\u003e Folate as L-5-methyltetrahydrofolate supports normal methylation, and niacinamide (vitamin B3) supports normal energy metabolism.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin C (from Magnesium and Zinc Ascorbate)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e111%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNiacinamide\u003c\/td\u003e\n\u003ctd\u003e122 mg\u003c\/td\u003e\n\u003ctd\u003e766%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFolate (from L-5-Methyltetrahydrofolate, LMTHF)\u003c\/td\u003e\n\u003ctd\u003e400 mcg DFE\u003c\/td\u003e\n\u003ctd\u003e100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium (from magnesium ascorbate)\u003c\/td\u003e\n\u003ctd\u003e22 mg\u003c\/td\u003e\n\u003ctd\u003e5%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (from zinc ascorbate)\u003c\/td\u003e\n\u003ctd\u003e11 mg\u003c\/td\u003e\n\u003ctd\u003e100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLion's Mane Extract (from \u003cem\u003eHercicium erinaceus\u003c\/em\u003e mushroom)\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eBacopa monnieri\u003c\/em\u003e whole plant extract (from Synapsa™, standardized to 55% Bacosides)\u003c\/td\u003e\n\u003ctd\u003e320 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCiticoline (from Cognizin®)\u003c\/td\u003e\n\u003ctd\u003e250 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eGinkgo biloba\u003c\/em\u003e Leaf Extract (contains 24% ginkgoflavonglycosides and 6% terpene lactones)\u003c\/td\u003e\n\u003ctd\u003e60 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eL-Theanine\u003c\/td\u003e\n\u003ctd\u003e30 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 2 Vegetarian Capsules. Servings per container: 30. Other ingredients: Vegetable Cellulose (from capsule shell), Organic Rice Extract, Silica, and Organic Rice Concentrate. The front label carries gluten-free, dairy-free and soy-free icons.\u003c\/p\u003e\n\u003ch2\u003eHow Brain Advantage works\u003c\/h2\u003e\n\u003ch3\u003eCognizin® citicoline (250 mg)\u003c\/h3\u003e\n\u003cp\u003eCiticoline, also called CDP-choline, is a compound your body already makes from two parts, choline and cytidine. Brain cells use them to build phosphatidylcholine, a main ingredient in cell membranes, and choline is also the raw material for acetylcholine, a messenger that attention and memory circuits rely on.† Cognizin, from Kyowa Hakko Bio, is the citicoline used in both studies below.\u003c\/p\u003e\n\u003cp\u003eIn a small 6-week study with no placebo group, 16 healthy adults (average age 47) took 500 mg or 2,000 mg of Cognizin a day, and brain scans showed higher energy reserves in the frontal lobe, including a 14% rise in a measure that mostly reflects ATP, the molecule cells spend as energy (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18816480\/\"\u003eSilveri et al., 2008\u003c\/a\u003e). In a 12-week placebo-controlled trial of 100 healthy adults aged 50 to 85 with mild, age-related memory changes, the 49 who took 500 mg a day improved more than the placebo group on episodic memory (remembering pairs of items) and an overall memory score (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33978188\/\"\u003eNakazaki et al., 2021\u003c\/a\u003e). Fair warning: those were secondary outcomes, scientists from Cognizin's maker were among the authors, and 500 mg is twice the amount in a serving here.\u003c\/p\u003e\n\u003ch3\u003eSynapsa™ bacopa (320 mg)\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eBacopa monnieri\u003c\/em\u003e is a creeping wetland herb with a long history in Ayurvedic tradition. Its active compounds, the bacosides, vary a lot from one extract to another, which is why this label states the standardization: 55% bacosides. Synapsa is the U.S. name for the extract sold in Australia as KeenMind.\u003c\/p\u003e\n\u003cp\u003eBacopa is a slow worker. In a 12-week placebo-controlled trial in healthy adults, 300 mg a day of KeenMind improved speed of visual information processing, learning rate and memory consolidation (how well newly learned information sticks), with the largest effects at week 12 rather than week 5 (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11498727\/\"\u003eStough et al., 2001\u003c\/a\u003e). A meta-analysis of nine placebo-controlled trials with 518 participants, testing standardized bacopa extracts for 12 weeks or more, found faster times on two attention and reaction-time tests (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24252493\/\"\u003eKongkeaw et al., 2014\u003c\/a\u003e). The differences were measured in milliseconds: statistically clear, but small.\u003c\/p\u003e\n\u003ch3\u003eLion's mane mushroom extract (500 mg)\u003c\/h3\u003e\n\u003cp\u003eLion's mane (\u003cem\u003eHericium erinaceus\u003c\/em\u003e) is an edible mushroom that looks like a shaggy white pom-pom, and its human research is early. In a pilot trial of 41 healthy adults aged 18 to 45, a single 1.8 g dose made people faster on one attention test an hour later, 28 days of use brought a trend toward lower self-reported stress that just missed statistical significance, and several other measures didn't change (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38004235\/\"\u003eDocherty et al., 2023\u003c\/a\u003e). That's more than three times the 500 mg here, so lion's mane is a supporting ingredient, not the reason to buy.\u003c\/p\u003e\n\u003ch3\u003eGinkgo biloba (60 mg) and L-theanine (30 mg)\u003c\/h3\u003e\n\u003cp\u003eThe ginkgo leaf extract is standardized to 24% ginkgoflavonglycosides and 6% terpene lactones, as the label states. L-theanine is an amino acid found in tea leaves. Both are here in supporting amounts, and we don't ask them to carry the formula.\u003c\/p\u003e\n\u003ch3\u003eThe vitamins and minerals\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eFolate (400 mcg DFE)\u003c\/strong\u003e comes as L-5-methyltetrahydrofolate, the form your body already uses, so there's no conversion step from folic acid. It supports normal methylation, a basic chemical process your cells run every day.† \u003cstrong\u003eNiacinamide (122 mg)\u003c\/strong\u003e is a form of vitamin B3 that your cells use to make NAD+, a coenzyme involved in turning food into energy,† and it doesn't cause the skin flushing that nicotinic acid can (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Niacin-HealthProfessional\/\"\u003eNIH niacin fact sheet\u003c\/a\u003e). \u003cstrong\u003eVitamin C (100 mg), magnesium (22 mg) and zinc (11 mg)\u003c\/strong\u003e arrive together as magnesium and zinc ascorbate, so the minerals come bound to the vitamin C. Vitamin C supports the body's normal antioxidant defenses, and many of your enzymes depend on zinc.†\u003c\/p\u003e\n\u003ch2\u003eHow to take Brain Advantage\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDirections on the label:\u003c\/strong\u003e \"Take two capsules daily, as a dietary supplement.\"\u003c\/p\u003e\n\u003cp\u003eTwo capsules is one serving, so a bottle lasts 30 days. Give it time: the 12-week bacopa and citicoline trials above measured results after three months of daily use.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. That goes double if you take a blood thinner or thyroid medication, since Brain Advantage contains ginkgo and bacopa.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. Fifty-two years in, we know a nice adjective isn't proof. Here's what is.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the citicoline and bacopa included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of Brain Advantage gets its own.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon, with globally sourced ingredients.\u003c\/strong\u003e Brain Advantage is formulated, made and tested in our UL-certified cGMP facility in Mt. Angel, a farm town of about 3,500 people in the Willamette Valley. Our formulators, makers and testers work under one roof, and the owners work in the building too. Owner-run since 2017, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow long does Brain Advantage take to work?\u003c\/h3\u003e\n\u003cp\u003ePlan on about 12 weeks of daily use before you judge it. In a placebo-controlled trial, bacopa's effects were largest at 12 weeks, and the citicoline memory trial also ran 12 weeks. Brain Advantage isn't a stimulant, so don't expect a jolt on day one.\u003c\/p\u003e\n\u003ch3\u003eDoes Brain Advantage have caffeine?\u003c\/h3\u003e\n\u003cp\u003eNo. There's no caffeine or other stimulant on the Supplement Facts panel, so you can keep your usual coffee or tea.\u003c\/p\u003e\n\u003ch3\u003eCan I take Brain Advantage with a multivitamin or CortiResponse?\u003c\/h3\u003e\n\u003cp\u003eUsually, yes, but add up the overlaps. Brain Advantage already gives you 122 mg of niacinamide, 400 mcg DFE of folate and 11 mg of zinc, so if you also take a multivitamin like our \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mens-multi-vitamin-60-capsules\"\u003eMen's Multi\u003c\/a\u003e or \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/womens-multi-cap-60ct\"\u003eWomen's Multi\u003c\/a\u003e, or a B-complex, check the totals on both labels. CortiResponse also contains L-theanine. If you take medication or aren't sure about a combination, ask your practitioner.\u003c\/p\u003e\n\u003ch3\u003eWhat makes Cognizin and Synapsa different from generic citicoline and bacopa?\u003c\/h3\u003e\n\u003cp\u003eThey're named, standardized ingredients you can trace to specific research: Cognizin is the citicoline in both citicoline studies above, and Synapsa is the U.S. name for the bacopa extract in the 12-week trial. A label that just says \"bacopa extract\" doesn't tell you which extract you're getting.\u003c\/p\u003e\n\u003ch3\u003eIs Brain Advantage safe to take with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first, and bring the bottle. Ginkgo and bacopa are the two ingredients worth naming, especially with a blood thinner or thyroid medication.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/bacopa-monnieri\"\u003eWhat the bacopa research does and doesn't show, trial by trial\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness, our formula for cellular energy and healthy NAD+ levels\u003c\/a\u003e†\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/cortiresponse-stress-mood-support\"\u003eCortiResponse, our ashwagandha and L-theanine formula for everyday stress\u003c\/a\u003e†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSilveri MM et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR in Biomedicine. 2008. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18816480\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eNakazaki E et al. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. The Journal of Nutrition. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33978188\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eStough C et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology. 2001. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11498727\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKongkeaw C et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of Ethnopharmacology. 2014. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24252493\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDocherty S et al. The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. 2023. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38004235\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":50978625356058,"sku":"015-M1005","price":61.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M1005_REV01_New_Item_Badge.png?v=1755624483"},{"product_id":"mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules","title":"Urolithin A 500 mg – Mitochondrial Renewal \u0026 Cellular Energy | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eMt. Angel Vitamins Urolithin A gives you 500 mg of urolithin A in a single capsule, with 60 capsules per bottle: a 60-day supply at the label's one capsule a day. Urolithin A is a compound some people's gut bacteria make from plant tannins in pomegranates, walnuts and berries. It supports mitophagy, the way your cells recycle worn-out mitochondria, for cellular energy, muscle strength and healthy aging.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAging isn't optional. Getting old is. Urolithin A is for people who want their muscles and their energy to keep up for the long haul: people in their late 30s and 40s already planning how they want to feel at 75, and people over 50 who intend to keep going strong. The strength and endurance trials enrolled adults from 40 to 90, so that's where the evidence lives.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Urolithin A\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial renewal.\u003c\/strong\u003e Supports mitophagy, the routine where cells tag worn-out mitochondria, take them apart and recycle the pieces.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular energy.\u003c\/strong\u003e Supports healthy mitochondrial function and cellular energy production.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle strength.\u003c\/strong\u003e In a 4-month trial in sedentary middle-aged adults, 500 mg a day supported leg muscle strength compared with placebo.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial health markers.\u003c\/strong\u003e In healthy older adults, 4 weeks at 500 mg a day shifted blood and muscle markers of mitochondrial health.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealthy aging.\u003c\/strong\u003e Supports the mitochondrial upkeep that tends to slow down as we get older.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eUrolithin A\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*Daily Value not established. Serving size: 1 Capsule. Servings per container: 60. Other ingredients: Cellulose (from capsule shell), brown rice protein, and vegetable stearates. The label states: \"NO soy, salt, yeast, gluten, wheat, milk \u0026amp; egg products, sugar, starch, or preservatives.\" One active ingredient, no proprietary blend.\u003c\/p\u003e\n\u003ch2\u003eHow Urolithin A works\u003c\/h2\u003e\n\u003ch3\u003eWhere urolithin A comes from\u003c\/h3\u003e\n\u003cp\u003eYou don't actually eat urolithin A. Pomegranates, walnuts and some berries contain ellagitannins, and certain gut bacteria convert those into urolithin A, if you carry them. In a study of 100 healthy adults, just 12% had detectable urolithin A in their blood at the start, and about 40% converted a meaningful amount after a glass of pomegranate juice. A 500 mg serving of urolithin A delivered more than six times the exposure of the juice (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34117375\/\"\u003eSingh et al., 2021\u003c\/a\u003e). Taking the finished compound means the same amount every day, no matter who lives in your gut.\u003c\/p\u003e\n\u003ch3\u003eMitophagy, in plain English\u003c\/h3\u003e\n\u003cp\u003eMitochondria are the parts of your cells that turn food and oxygen into usable energy. They wear out. A worn mitochondrion makes less energy and more junk, so healthy cells tag the damaged ones, break them down and recycle the parts so replacements can be built. That cleanup is called mitophagy, and it tends to slow down as we get older, right about when you'd want it running well. Urolithin A supports that recycling process.†\u003c\/p\u003e\n\u003cp\u003eThe human evidence for the mechanism comes from muscle, because muscle is packed with mitochondria and easy to sample. In the first human study, 4 weeks at 500 mg or 1,000 mg a day shifted blood and muscle markers of mitochondrial health in healthy, sedentary older adults (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32694802\/\"\u003eAndreux et al., 2019\u003c\/a\u003e). In a 4-month trial, the 500 mg daily dose raised the active form of Parkin, one of the proteins that marks a mitochondrion for recycling, in muscle samples (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). It doesn't add energy from the outside; it supports maintenance your cells already do.†\u003c\/p\u003e\n\u003ch3\u003eWhat the human trials found\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eStrength in middle age.\u003c\/strong\u003e In a 4-month randomized, placebo-controlled trial, 88 sedentary adults aged 40 to 64 took 500 mg, 1,000 mg or placebo daily. Average hamstring strength improved about 12% in the 500 mg group and 9.8% in the 1,000 mg group, both significant compared with placebo, while the placebo group's strength dropped. The trial's main goal, peak power output on a bike, did not differ from placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEndurance after 65.\u003c\/strong\u003e In a 4-month trial in 66 adults aged 65 to 90, half took 1,000 mg a day and half took placebo. Endurance in a hand muscle and a leg muscle (contractions until fatigue) improved with urolithin A compared with placebo at 2 months. The trial's two main goals, 6-minute walk distance and peak muscle energy production, did not differ from placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\"\u003eLiu et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eWhat the research doesn't show\u003c\/h3\u003e\n\u003cp\u003ePlenty, and you should know it. In a 4-week trial in 42 highly trained male distance runners, 1,000 mg a day did not improve 3,000 m time-trial results, though effort ratings and a blood marker of muscle damage after the time trial were lower than with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40839339\/\"\u003eWhitfield et al., 2025\u003c\/a\u003e). If you're 28 and already training hard, this probably isn't your first purchase. The longest trials cited here ran 4 months, so they can't tell you what years of use look like. Every study cited here had co-authors from the company that developed the ingredient they tested. And none of them tested this exact bottle: they tested urolithin A itself at 500 mg and 1,000 mg a day.\u003c\/p\u003e\n\u003ch3\u003eWhy 500 mg in one capsule\u003c\/h3\u003e\n\u003cp\u003e500 mg is the lower of the two daily amounts in the 4-month middle-aged trial, and that group's hamstring strength gain (about 12%) was in the same range as the 1,000 mg group's (9.8%). One honest caveat: the trial in adults over 65 used only 1,000 mg.\u003c\/p\u003e\n\u003ch2\u003eHow to take Urolithin A\u003c\/h2\u003e\n\u003cp\u003eLabel directions: \"Take 1 capsule daily, as a dietary supplement.\"\u003c\/p\u003e\n\u003cp\u003eIn the middle-aged trial, people took urolithin A in the morning before breakfast with water (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). No study has compared timing or food, so pick the time you'll stick with.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, urolithin A included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eSee the certificates of analysis for this product\u003c\/a\u003e and match one to the lot number on your bottle.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon, with globally sourced ingredients.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and our UL-certified cGMP facility sits right in it. The people who formulate, make and test this capsule work under one roof, and the owners work in the building too. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much urolithin A is in each capsule?\u003c\/h3\u003e\n\u003cp\u003eEach capsule contains 500 mg of urolithin A, and the label serving is one capsule a day. With 60 capsules in the bottle, that's a 60-day supply.\u003c\/p\u003e\n\u003ch3\u003eWhen should I take it, and does it need food?\u003c\/h3\u003e\n\u003cp\u003eTake one capsule a day at whatever time you'll remember. The label doesn't name a time, and no study has compared timing or food.\u003c\/p\u003e\n\u003ch3\u003eHow long until I notice something?\u003c\/h3\u003e\n\u003cp\u003eThink months, not days. Urolithin A isn't a stimulant, so there's no jolt to feel. The trials measured muscle endurance at 2 months and strength at 4 months, so give it two to four months of daily use before you judge it.†\u003c\/p\u003e\n\u003ch3\u003eCan't I just eat more pomegranates?\u003c\/h3\u003e\n\u003cp\u003eEat them anyway, but they may not get you much urolithin A. Pomegranates contain the raw material, not urolithin A itself, and only some people's gut bacteria convert it well. A 500 mg serving of urolithin A gave more than six times the exposure of a glass of pomegranate juice (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34117375\/\"\u003eSingh et al., 2021\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eCan I take it with NMN + NR or CoQ10?\u003c\/h3\u003e\n\u003cp\u003eWe haven't found a published trial that tested urolithin A together with NMN, NR or CoQ10, so we can't promise the combination adds up to more. People pair them because they work on different parts of the same system: urolithin A supports recycling worn-out mitochondria, NMN and NR are building blocks for NAD+, which mitochondria use to make energy, and CoQ10 works inside the energy-making chain itself.† Taking medication? Check with your practitioner before combining supplements.\u003c\/p\u003e\n\u003ch3\u003eIs it safe to take with my medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first. The middle-aged trial excluded people taking statins, blood thinners, steroids or thyroid medication, so there is no trial data for those combinations. In the two 4-month trials, adverse events with urolithin A were similar to placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\"\u003eLiu et al., 2022\u003c\/a\u003e; \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eIs urolithin A a probiotic?\u003c\/h3\u003e\n\u003cp\u003eNo. It's often called a postbiotic: a compound that gut bacteria make, rather than the bacteria themselves. This capsule contains urolithin A, not live cultures.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/urolithin-a\"\u003eUrolithin A ingredient guide: where it comes from, what the trials measured, and safety\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness, for the NAD+ side of cellular energy\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/coq10-alpha-lipoic-acid\"\u003eCoQ10 + Alpha Lipoic Acid, for the energy-making chain inside mitochondria\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack Starter: one bottle each of Urolithin A and NMN + NR\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eAndreux PA et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32694802\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSingh A et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. European Journal of Clinical Nutrition. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34117375\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLiu S et al. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Network Open. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWhitfield J et al. Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. Sports Medicine. 2025. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40839339\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":51859753042202,"sku":"015-M3200","price":89.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M3200REV02_ListingImage1.png?v=1774269533"},{"product_id":"mitochondria-stack-starter","title":"Mitochondria Stack Starter – Cellular Energy Support | 1 Bottle Each","description":"\u003cp\u003e\u003cstrong\u003eThe Mitochondria Stack Starter is one 60-capsule bottle of Urolithin A (500 mg per 1-capsule serving) and one 60-capsule bottle of NMN + NR Cellular Wellness (500 mg NMN and 200 mg nicotinamide riboside per 2-capsule serving, with resveratrol, TMG, Bioperine® and zinc). Urolithin A supports mitochondrial renewal, and NMN + NR supports healthy NAD+ levels for cellular energy.† Bundle price: $129.99, versus $149.98 bought separately, so you save $19.99.\u003c\/strong\u003e\u003c\/p\u003e\r\n\u003cp\u003eYour cells run on mitochondria, and keeping them working takes two jobs: clearing out the worn-out ones, and keeping the rest supplied with NAD+, a coenzyme they need to turn food into usable energy. This stack puts one product on each job.† It's built for people in their late 30s and 40s who are already working on energy and cellular health, and for anyone past 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\r\n\u003ch2\u003eUrolithin A: the cleanup crew\u003c\/h2\u003e\r\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A\u003c\/a\u003e is a single-ingredient formula: 500 mg of urolithin A in each 1-capsule serving, 60 servings per bottle. The label says it supports mitochondrial renewal, cellular energy, and promotes healthy aging.†\u003c\/p\u003e\r\n\u003cp\u003eYour gut bacteria make urolithin A from ellagitannins, the polyphenols in pomegranates, walnuts and some berries, and how much you make varies a lot from person to person: in one trial, only about 15% of participants had any in their blood at the start (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). Taking it directly skips that step. In research, it's mainly studied for supporting mitophagy, the process cells use to tag worn-out mitochondria and recycle them so healthier ones carry the load.†\u003c\/p\u003e\r\n\u003cp\u003eIn a 4-month randomized trial in 88 untrained middle-aged adults taking 500 mg or 1,000 mg daily, hamstring strength rose about 12% at 500 mg (about 10% at 1,000 mg) compared with placebo, and muscle samples showed more of the proteins tied to mitophagy and mitochondrial metabolism. The trial's main measure, peak power output, did not improve significantly, and the study was run by the developer of the urolithin A it tested (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\r\n\u003ch2\u003eNMN + NR Cellular Wellness: the fuel line\u003c\/h2\u003e\r\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness\u003c\/a\u003e comes as 60 capsules, 30 servings of 2 capsules. Each serving contains:\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003eβ-Nicotinamide Mononucleotide: 500 mg\u003c\/li\u003e\r\n\u003cli\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root): 250 mg\u003c\/li\u003e\r\n\u003cli\u003eNicotinamide riboside: 200 mg\u003c\/li\u003e\r\n\u003cli\u003eTrimethylglycine (TMG) (Betaine anhydrous): 50 mg\u003c\/li\u003e\r\n\u003cli\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit): 50 mg\u003c\/li\u003e\r\n\u003cli\u003eZinc (as bisglycinate chelate): 10 mg\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003eNMN and NR are vitamin B3 compounds that your body turns into NAD+. Mitochondria use NAD+ to make energy, and enzymes called sirtuins depend on it too. NR is converted into NMN, and NMN becomes NAD+ in one more step, so the formula covers both entry points. The label says it supports cellular energy production and maintains healthy NAD+ levels.†\u003c\/p\u003e\r\n\u003cp\u003eThe supporting cast: resveratrol from Japanese knotweed root (\u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e), TMG (betaine, a methyl donor), Bioperine® from black pepper fruit (\u003cem\u003ePiper nigrum\u003c\/em\u003e), and zinc as a bisglycinate chelate (zinc bound to glycine).\u003c\/p\u003e\r\n\u003cp\u003eIn a 60-day randomized trial in 80 healthy middle-aged adults, NMN at 300, 600 or 900 mg once daily raised blood NAD+ in every dose group, was well tolerated, and increased six-minute walking distance more than placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003eYi et al., 2022\u003c\/a\u003e). In a small 6-week crossover trial in 30 healthy adults aged 55 to 79, NR at 1,000 mg a day (one serving here has 200 mg) was well tolerated and raised NAD+ in blood cells by about 60% compared with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003eMartens et al., 2018\u003c\/a\u003e). Each trial tested one ingredient alone, not this formula or this stack.\u003c\/p\u003e\r\n\u003ch2\u003eHow to take them together\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eUrolithin A:\u003c\/strong\u003e Take 1 capsule daily, as a dietary supplement.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eNMN + NR Cellular Wellness:\u003c\/strong\u003e Take 2 capsules daily, as a dietary supplement (a 30-day supply per bottle).\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003eNeither product's directions name a time of day or mention food.\u003c\/p\u003e\r\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\r\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003ethe certificates of analysis for Urolithin A\u003c\/a\u003e and \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003ethe certificates of analysis for NMN + NR Cellular Wellness\u003c\/a\u003e.\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e Both bottles come out of our UL-certified cGMP facility in a Willamette Valley farm town of about 3,500, where formulators, makers and testers work under one roof and the owners work in the building too. We've been making supplements in Oregon since 1974, and we're not getting old either.\u003c\/p\u003e\r\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\r\n\u003ch3\u003eWhat's the difference between urolithin A and NMN?\u003c\/h3\u003e\r\n\u003cp\u003eThey work on different parts of the same system. Urolithin A supports mitophagy, the recycling of worn-out mitochondria, while NMN and NR are building blocks for NAD+, the coenzyme mitochondria use to make energy.† See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/urolithin-a-vs-nmn\"\u003ehow urolithin A and NMN differ\u003c\/a\u003e.\u003c\/p\u003e\r\n\u003ch3\u003eWhy buy the stack instead of the two bottles separately?\u003c\/h3\u003e\r\n\u003cp\u003eThe price. The Starter is $129.99, and the same two bottles bought separately come to $149.98, so you save $19.99. They're the same products with the same labels.\u003c\/p\u003e\r\n\u003ch3\u003eHow soon will I notice anything?\u003c\/h3\u003e\r\n\u003cp\u003eThere's no set timeline, and many changes researchers track are measured in a lab, not felt. The trials above ran from 6 weeks to 4 months, so judge it on steady daily use, not one week.\u003c\/p\u003e\r\n\u003ch3\u003eCan I take this stack with medication?\u003c\/h3\u003e\r\n\u003cp\u003eAsk your healthcare practitioner first, and bring both labels along.\u003c\/p\u003e\r\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/urolithin-a-complete-guide\"\u003eThe full guide to urolithin A: dose, trials and safety\u003c\/a\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/nad-longevity-complete-guide\"\u003eHow NAD+ works and what NMN and NR do\u003c\/a\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-double\"\u003eMitochondria Stack Double, 2 bottles of each\u003c\/a\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch2\u003eReferences\u003c\/h2\u003e\r\n\u003col\u003e\r\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":52626906448154,"sku":"MITO-STACK-1M","price":129.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/22ee0c8d4d34e9cd2218d5b90cfc3978.jpg?v=1785694676"},{"product_id":"mitochondria-stack-double","title":"Mitochondria Stack Double – Cellular Energy Support | 2 Bottles Each","description":"\u003cp\u003e\u003cstrong\u003eThe Mitochondria Stack Double is two 60-capsule bottles of Urolithin A (500 mg per 1-capsule serving) and two 60-capsule bottles of NMN + NR Cellular Wellness (500 mg NMN and 200 mg nicotinamide riboside per 2-capsule serving). Urolithin A supports mitochondrial renewal, and NMN + NR supports healthy NAD+ levels for cellular energy.† Bundle price: $249.99, versus $299.96 bought separately, so you save $49.97.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYour mitochondria turn food into energy, and keeping them in shape takes two jobs: recycling the worn-out ones and keeping the rest supplied with NAD+. This stack puts one product on each job.† It's for people in their late 30s and 40s already working on energy and cellular health, and anyone past 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eUrolithin A 500 mg: two bottles for mitochondrial renewal\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A\u003c\/a\u003e is a single-ingredient formula: 500 mg of urolithin A per 1-capsule serving, 60 servings per bottle. The label says it supports mitochondrial renewal, cellular energy, and promotes healthy aging.†\u003c\/p\u003e\n\u003cp\u003eGut bacteria make urolithin A from ellagitannins in pomegranates, berries and walnuts, but not everyone makes much. In one trial, only about 15% of participants had any in their blood at the start (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). Taking it directly skips that step. It's studied mainly for mitophagy, the process cells use to recycle worn-out mitochondria.†\u003c\/p\u003e\n\u003cp\u003eThat trial ran 4 months, the same as two bottles at one capsule a day. In 88 untrained adults aged 40 to 64 with low baseline fitness, 500 mg a day raised hamstring strength about 12% versus placebo, and muscle samples showed more of the proteins tied to mitophagy and mitochondrial metabolism. The main measure, peak power output, did not improve significantly, and most of its authors worked for the company that developed the urolithin A it tested. Dose and safety detail: \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/urolithin-a-complete-guide\"\u003ethe full guide to urolithin A\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eNMN + NR Cellular Wellness: two bottles for NAD+ support\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness\u003c\/a\u003e comes as 60 capsules per bottle, 30 servings of 2 capsules. Each serving contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eβ-Nicotinamide Mononucleotide: 500 mg\u003c\/li\u003e\n\u003cli\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root): 250 mg\u003c\/li\u003e\n\u003cli\u003eNicotinamide riboside: 200 mg\u003c\/li\u003e\n\u003cli\u003eTrimethylglycine (TMG) (Betaine anhydrous): 50 mg\u003c\/li\u003e\n\u003cli\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit): 50 mg\u003c\/li\u003e\n\u003cli\u003eZinc (as bisglycinate chelate): 10 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNMN and NR are vitamin B3 compounds your body turns into NAD+, which mitochondria use to make energy. NR becomes NMN, and NMN becomes NAD+, so the formula covers both entry points. The label says it supports cellular energy production and maintains healthy NAD+ levels.† Rounding it out: resveratrol from Japanese knotweed root, TMG (a methyl donor), black pepper fruit extract, and zinc bound to glycine.\u003c\/p\u003e\n\u003cp\u003eIn a 60-day randomized trial in 80 healthy middle-aged adults, NMN at 300, 600 or 900 mg once daily raised blood NAD+ at every dose, was well tolerated, and increased six-minute walking distance more than placebo, most at 600 and 900 mg (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003eYi et al., 2022\u003c\/a\u003e). In a small 6-week crossover trial in 30 healthy adults aged 55 to 79, NR at 1,000 mg a day (five times one serving here) was well tolerated and raised NAD+ in blood cells about 60% over placebo, with no clear change in aerobic capacity (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003eMartens et al., 2018\u003c\/a\u003e). More on \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/nad-longevity-complete-guide\"\u003ehow NAD+ works and what NMN and NR can and can't do\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eThe honest limits: each trial tested one ingredient on its own, not these formulas and not the two products together, and each had industry involvement, from company-employed authors or study capsules supplied by the ingredient's maker.\u003c\/p\u003e\n\u003ch2\u003eHow to take them together\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrolithin A:\u003c\/strong\u003e Take 1 capsule daily, as a dietary supplement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNMN + NR Cellular Wellness:\u003c\/strong\u003e Take 2 capsules daily, as a dietary supplement.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNeither label names a time of day or mentions food, so pick a time you'll remember. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are rejected.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003ethe certificates of analysis for Urolithin A\u003c\/a\u003e and \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003ethe certificates of analysis for NMN + NR Cellular Wellness\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon.\u003c\/strong\u003e We make and test both products, from globally sourced ingredients, in our UL-certified cGMP facility in this Willamette Valley farm town of about 3,500. Formulators, makers and testers work under one roof, and the owners work in the building too (owner-run since 2017). We've been making supplements in Oregon since 1974, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eWhat's the difference between the Double and the Starter?\u003c\/h3\u003e\n\u003cp\u003eThe Double has twice as much of each product and a bigger discount. The \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack Starter\u003c\/a\u003e is one bottle of each for $129.99, a $19.99 savings. The Double is two of each for $249.99, $49.97 less than buying the four bottles separately.\u003c\/p\u003e\n\u003ch3\u003eHow long does the Double last?\u003c\/h3\u003e\n\u003cp\u003eAt one serving a day, it lasts 120 days for Urolithin A and 60 days for NMN + NR, about the length of the trials above. NMN + NR uses 2 capsules a day to Urolithin A's 1, so it runs out first.\u003c\/p\u003e\n\u003ch3\u003eWhy take urolithin A and NMN together?\u003c\/h3\u003e\n\u003cp\u003eThey support different parts of the same system: urolithin A supports recycling of worn-out mitochondria, and NMN and NR are building blocks for the NAD+ mitochondria use to make energy.† See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/urolithin-a-vs-nmn\"\u003ehow urolithin A and NMN differ\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow soon will I notice anything?\u003c\/h3\u003e\n\u003cp\u003eThere's no set timeline, and many changes researchers track are measured in a lab, not felt. The trials above ran 6 weeks to 4 months, so give it steady daily use over that kind of stretch.\u003c\/p\u003e\n\u003ch3\u003eWhat's not in these capsules?\u003c\/h3\u003e\n\u003cp\u003eEach label prints its own list. Urolithin A: \"NO soy, salt, yeast, gluten, wheat, milk \u0026amp; egg products, sugar, starch, or preservatives.\" NMN + NR: \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\"\u003c\/p\u003e\n\u003ch3\u003eCan I take this stack with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first, and bring both labels along.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":52626906480922,"sku":"MITO-STACK-2M","price":249.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/22ee0c8d4d34e9cd2218d5b90cfc3978_f6209074-002e-4dcc-a7e2-aca2b05e8b8c.jpg?v=1785694687"},{"product_id":"mitochondria-stack-triple","title":"Mitochondria Stack Triple – Cellular Energy Support | 3 Bottles Each","description":"\u003cp\u003e\u003cstrong\u003eThe Mitochondria Stack Triple is three 60-capsule bottles of Urolithin A (500 mg per 1-capsule serving) and three 60-capsule bottles of NMN + NR Cellular Wellness (500 mg NMN and 200 mg nicotinamide riboside per 2-capsule serving, with resveratrol, TMG, Bioperine® and zinc). Urolithin A supports mitochondrial renewal, and NMN + NR supports healthy NAD+ levels for cellular energy.† Bundle price: $349.99, versus $449.94 bought separately, so you save $99.95.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYour cells make most of their energy in mitochondria, and keeping them in shape takes two jobs: recycling the worn-out ones and keeping the rest supplied with NAD+, a coenzyme they need to turn food into energy. This stack puts one product on each job.† The Triple is the long-haul size, built for people in their late 30s and 40s who are working on energy and cellular health so they can thrive in their 70s and 80s, and for anyone past 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eUrolithin A: the recycling crew\u003c\/h2\u003e\n\u003cp\u003eThree bottles of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A\u003c\/a\u003e: 500 mg of urolithin A in each 1-capsule serving, 60 servings per bottle. The label says it supports mitochondrial renewal, cellular energy, and promotes healthy aging.†\u003c\/p\u003e\n\u003cp\u003eGut bacteria make urolithin A from ellagitannins, polyphenols in pomegranates, berries and walnuts, and how much a person makes varies a lot: in one trial, only about 15% of participants had any in their blood at the start (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). Taking it directly skips that step. It's studied mainly for mitophagy, the process cells use to tag worn-out mitochondria and recycle them so healthier ones carry the load.† Dosage, the research and safety are covered in \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/urolithin-a\"\u003ethe urolithin A ingredient guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eIn that 4-month randomized, placebo-controlled trial in 88 untrained adults aged 40 to 64 with low aerobic fitness, average hamstring strength rose about 12% on 500 mg a day (about 10% on 1,000 mg) while it fell in the placebo group, a significant difference, and muscle samples showed more of the proteins tied to mitophagy and mitochondrial metabolism. The limits: the main measure, peak power output, did not improve significantly, and several authors work for the company that makes the urolithin A tested.\u003c\/p\u003e\n\u003ch2\u003eNMN + NR Cellular Wellness: the fuel line\u003c\/h2\u003e\n\u003cp\u003eThree bottles of \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness\u003c\/a\u003e, 30 two-capsule servings per bottle. Each serving contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eβ-Nicotinamide Mononucleotide: 500 mg\u003c\/li\u003e\n\u003cli\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root): 250 mg\u003c\/li\u003e\n\u003cli\u003eNicotinamide riboside: 200 mg\u003c\/li\u003e\n\u003cli\u003eTrimethylglycine (TMG) (Betaine anhydrous): 50 mg\u003c\/li\u003e\n\u003cli\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit): 50 mg\u003c\/li\u003e\n\u003cli\u003eZinc (as bisglycinate chelate): 10 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNMN and NR are both built from vitamin B3, and your body turns both into NAD+, which mitochondria use to make energy.† Inside cells, NR becomes NMN and NMN becomes NAD+, and this formula includes both. The label says it supports cellular energy production and maintains healthy NAD+ levels.† Alongside them: resveratrol from Japanese knotweed root, TMG (betaine, a methyl donor), Bioperine® black pepper fruit extract, and zinc as a bisglycinate chelate, meaning zinc bound to the amino acid glycine.\u003c\/p\u003e\n\u003cp\u003eIn a 60-day randomized trial in 80 healthy middle-aged adults, NMN at 300, 600 or 900 mg once daily raised blood NAD+ at every dose, was well tolerated, and increased six-minute walking distance more than placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003eYi et al., 2022\u003c\/a\u003e). In a small 6-week crossover trial in healthy adults aged 55 to 79, NR at 1,000 mg a day was well tolerated and raised NAD+ in blood cells about 60% compared with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003eMartens et al., 2018\u003c\/a\u003e). The limits: each trial tested one ingredient alone, not this formula or this stack, the NR trial used 1,000 mg a day (a serving here has 200 mg), and the NMN trial was co-sponsored by the companies that make the NMN it tested, with a lead author from one of them.\u003c\/p\u003e\n\u003ch2\u003eHow to take them together\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrolithin A:\u003c\/strong\u003e Take 1 capsule daily, as a dietary supplement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNMN + NR Cellular Wellness:\u003c\/strong\u003e Take 2 capsules daily, as a dietary supplement.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThat's 3 capsules a day between the two. Neither label's directions name a time of day or mention food. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003ethe certificates of analysis for Urolithin A\u003c\/a\u003e and \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003ethe certificates of analysis for NMN + NR Cellular Wellness\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA with globally sourced ingredients, in Mt. Angel, Oregon.\u003c\/strong\u003e All six bottles come out of our UL-certified cGMP facility in a Willamette Valley farm town of about 3,500. Formulators, makers and testers work under one roof, and the owners work in the building too. The company has been owner-run since 2017. We've been making supplements in Oregon since 1974, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow long does the Mitochondria Stack Triple last?\u003c\/h3\u003e\n\u003cp\u003e90 days for NMN + NR (each bottle is a 30-day supply) and 180 days for Urolithin A, so you'll still have Urolithin A on hand when the NMN + NR runs out.\u003c\/p\u003e\n\u003ch3\u003eWhy the Triple instead of a smaller size?\u003c\/h3\u003e\n\u003cp\u003eIt costs the least per bottle. The Triple works out to about $116.66 for each pair of bottles, versus about $125 with the \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-double\"\u003eMitochondria Stack Double\u003c\/a\u003e, $129.99 with the \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack Starter\u003c\/a\u003e, and $149.98 bought separately. Same products, same labels.\u003c\/p\u003e\n\u003ch3\u003eWhat's the difference between urolithin A and NMN?\u003c\/h3\u003e\n\u003cp\u003eThey do different jobs in the same system. Urolithin A supports the recycling of worn-out mitochondria, while NMN and NR are building blocks for NAD+.† This stack gives you one of each.\u003c\/p\u003e\n\u003ch3\u003eCan I take both at the same time?\u003c\/h3\u003e\n\u003cp\u003eNothing in either label's directions says to take them separately, so all 3 capsules together is the simplest routine. On medication? Ask your healthcare practitioner first and bring both labels.\u003c\/p\u003e\n\u003ch3\u003eHow soon will I notice anything?\u003c\/h3\u003e\n\u003cp\u003eThere's no set timeline, and most of what researchers track is measured in a lab, not felt. The trials above ran 6 weeks to 4 months, and the Triple gives you 90 days of both.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":52626906513690,"sku":"MITO-STACK-3M","price":349.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/22ee0c8d4d34e9cd2218d5b90cfc3978_60c657a0-58b6-416e-94c4-4aa8242d7429.jpg?v=1785694699"}],"url":"https:\/\/www.mtangelvitamins.com\/collections\/new-science.oembed","provider":"Mt. Angel Vitamins","version":"1.0","type":"link"}