{"title":"Starting Now: Supplements for Your Late 30s and 40s","description":"\u003cp\u003eWhat you do in your 30s and 40s shapes how you'll feel in your 70s and 80s. Most people start with the essentials (a multivitamin, vitamin D, B12 and magnesium), then add newer science for cellular energy, like Urolithin A or NMN + NR.† Under steady stress? CortiResponse helps maintain healthy cortisol levels.†\u003c\/p\u003e","products":[{"product_id":"good-magnesium-chelate-amino-acids","title":"Good Magnesium 200 mg – Muscle and Nerve Support | 60 Vegetarian Capsules","description":"\u003cp\u003e\u003cstrong\u003eGood Magnesium is a magnesium supplement with 200 mg of magnesium as rice protein chelate in every vegetarian capsule, 47% of the Daily Value. The other ingredients include parsley leaf, holy basil and ginger root. Each bottle holds 60 vegetarian capsules, and one capsule is a serving. It supports normal muscle function, nervous system function and relaxation.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGood Magnesium is for adults who want a simple, one-capsule way to top up a mineral a lot of us run short on. The NIH Office of Dietary Supplements notes that many people in the United States get less magnesium from food than recommended (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Magnesium-HealthProfessional\/\"\u003ethe NIH magnesium fact sheet\u003c\/a\u003e). If you train hard, sit through long and stressful workdays, or are building a better bedtime routine, magnesium is one of the basics worth getting right.\u003c\/p\u003e\n\u003cp\u003eAging isn't optional. Getting old is. The habits that keep you moving well in your 70s and 80s start in your 30s and 40s, and most of them are boring: sleep, strength, decent food, small nutrient gaps closed. This is one of the boring ones, and we mean that as a compliment.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Good Magnesium\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports normal muscle function, so muscles can contract and relax the way they're built to.†\u003c\/li\u003e\n\u003cli\u003eSupports normal nervous system function and a healthy response to everyday stress.†\u003c\/li\u003e\n\u003cli\u003eSupports normal energy production in your cells.†\u003c\/li\u003e\n\u003cli\u003eSupports relaxation and normal sleep quality as part of an evening routine.†\u003c\/li\u003e\n\u003cli\u003eHelps close a common nutrient gap with 200 mg, or 47% of the Daily Value, in one capsule.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium (rice protein chelate)\u003c\/td\u003e\n\u003ctd\u003e200 mg\u003c\/td\u003e\n\u003ctd\u003e47%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 1 Vegetarian Capsule. Each bottle holds 60 vegetarian capsules, which is 60 servings at the label's one-capsule serving. Other ingredients: Vegetable cellulose (preservative-free, from capsule shell), L-leucine, organic rice concentrate, parsley leaf (Petroselinum crispun), holy basil herb (Ocimum sanctum), and ginger root (Zingiber officinale). The label states: \"NO corn, soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\"\u003c\/p\u003e\n\u003ch2\u003eHow Good Magnesium works\u003c\/h2\u003e\n\u003ch3\u003eMagnesium: 200 mg per capsule\u003c\/h3\u003e\n\u003cp\u003eMagnesium is a cofactor in more than 300 enzyme systems, the reactions behind building protein, muscle and nerve function, and energy production (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Magnesium-HealthProfessional\/\"\u003eNIH Office of Dietary Supplements\u003c\/a\u003e).† Less than 1% of the magnesium in your body is in your blood serum, and a standard serum test doesn't necessarily reflect how much your body holds overall (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26069819\/\"\u003ea review of magnesium basics\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003eAdults need 400 to 420 mg a day (men) or 310 to 320 mg (women who aren't pregnant) from all sources, depending on age. One capsule gives you 200 mg, 47% of the Daily Value. It's built to top up a decent diet, not replace one.\u003c\/p\u003e\n\u003ch3\u003eThe rice protein chelate\u003c\/h3\u003e\n\u003cp\u003eThe label lists the magnesium as rice protein chelate. A chelate (say \"KEE-late\") is a mineral bound to amino acids, here amino acids from rice protein. Researchers group amino acid chelates and citrate with the organic forms of magnesium, and magnesium oxide and other simple mineral salts with the inorganic forms.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34111673\/\"\u003eA systematic review of 14 magnesium bioavailability studies\u003c\/a\u003e concluded that inorganic forms appear less bioavailable than organic ones, and that the share you absorb depends on the dose. It also notes that in healthy people who weren't low to begin with, all the forms studied could maintain normal magnesium levels. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14596323\/\"\u003ea 60-day randomized, double-blind trial in 46 healthy people\u003c\/a\u003e taking 300 mg a day, an amino acid chelate and magnesium citrate both showed greater absorption than magnesium oxide (by 24-hour urine magnesium), and oxide was no different from placebo. Citrate produced the highest blood levels. The limits: it was a small study, and it tested an amino acid chelate, not our rice protein chelate specifically.\u003c\/p\u003e\n\u003ch3\u003eMuscles and energy\u003c\/h3\u003e\n\u003cp\u003eMagnesium takes part in energy metabolism and helps maintain normal muscle function.† \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28846654\/\"\u003eA review of magnesium and exercise performance\u003c\/a\u003e found that the need for magnesium rises with physical activity, and that surveys link better magnesium status with muscle performance such as grip strength and leg power. Some supplement trials suggested gains in measures such as thigh muscle torque, but most human studies tracked heart rate, blood pressure or oxygen use rather than performance itself. Straight talk: that's a long way from extra magnesium turning into a personal record. It supports the normal muscle function you already have.†\u003c\/p\u003e\n\u003ch3\u003eStress and the nervous system\u003c\/h3\u003e\n\u003cp\u003eMagnesium helps regulate the signals your nervous system uses during a normal stress response.† \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33260549\/\"\u003eA 2020 review of magnesium and stress\u003c\/a\u003e describes a two-way street: stress may increase the magnesium your body loses, and low magnesium may leave you more sensitive to stress. The idea rests on lab research and on studies that measured magnesium in stressed people, so think of it as a reason to keep your intake steady, not a promise of calm in a capsule.\u003c\/p\u003e\n\u003ch3\u003eRelaxation and sleep\u003c\/h3\u003e\n\u003cp\u003eIn \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40918053\/\"\u003ea 2025 randomized, placebo-controlled trial in 155 healthy adults who reported poor sleep\u003c\/a\u003e, 250 mg of magnesium a day (as bisglycinate, another amino acid chelate) improved sleep questionnaire scores more than placebo after 4 weeks, but the difference was small. Exploratory analyses hinted that people who ate less magnesium improved more. Different form, slightly higher dose, self-reported sleep. So: a modest signal, most likely to matter if your diet runs low.†\u003c\/p\u003e\n\u003ch3\u003eParsley, holy basil, ginger and the rest\u003c\/h3\u003e\n\u003cp\u003eParsley leaf, holy basil herb and ginger root are listed among the other ingredients, and the front of the bottle reads \"Magnesium plus Herbs.\" The label doesn't give their amounts, so we don't make claims for them. L-leucine (an amino acid) and organic rice concentrate are also listed, and the capsule shell is vegetable cellulose.\u003c\/p\u003e\n\u003ch2\u003eHow to take Good Magnesium\u003c\/h2\u003e\n\u003cp\u003eThe label says: \"One or more capsules daily, as a dietary supplement.\"\u003c\/p\u003e\n\u003cp\u003eOne capsule gives you 200 mg. The NIH lists an adult upper limit of 350 mg a day for magnesium from supplements, because higher supplement doses can cause loose stools, nausea and stomach cramping (magnesium from food doesn't count toward it). Two capsules would be 400 mg, so talk with your practitioner before taking more than one a day, and count the magnesium in your other supplements.\u003c\/p\u003e\n\u003cp\u003eMagnesium can reduce how well your body absorbs some medications, including tetracycline and quinolone antibiotics and oral bisphosphonates, so doses may need to be spaced hours apart. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the magnesium chelate included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/good-magnesium-chelate-amino-acids\"\u003eSee the certificates of analysis for Good Magnesium\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and our UL-certified cGMP facility is right there. Formulators, makers and testers work under one roof, so the people who write the spec, the people who fill the capsules and the people who test the lot share a building. The owners work there too, and have since 2017. We've been making supplements in Oregon since 1974, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much magnesium is in each capsule?\u003c\/h3\u003e\n\u003cp\u003eEach capsule has 200 mg of magnesium as rice protein chelate, 47% of the Daily Value. One capsule is a serving, and a bottle holds 60.\u003c\/p\u003e\n\u003ch3\u003eHow many capsules should I take a day?\u003c\/h3\u003e\n\u003cp\u003eThe label says one or more capsules daily, and one capsule is 200 mg. The NIH lists an adult upper limit of 350 mg a day for magnesium from supplements, so check with your practitioner before going to two capsules (400 mg).\u003c\/p\u003e\n\u003ch3\u003eWhen should I take it, and does it need food?\u003c\/h3\u003e\n\u003cp\u003eTake it whenever you'll remember it. The label doesn't name a time or mention food. Many people like it in the evening as part of winding down.\u003c\/p\u003e\n\u003ch3\u003eHow long until I notice a difference?\u003c\/h3\u003e\n\u003cp\u003eMany people won't feel a switch flip, because magnesium works in the background of normal muscle and nerve function.† In the sleep trial above, the small difference was measured after 4 weeks of daily use, so give it about a month of steady use before you judge.\u003c\/p\u003e\n\u003ch3\u003eCan I take Good Magnesium with other Mt. Angel Vitamins products?\u003c\/h3\u003e\n\u003cp\u003eYes, but add up the magnesium first. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/calming-magnesium-powder-relax\"\u003eCalming Mag Powder\u003c\/a\u003e and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/natural-sleep-aid-herbal-support\"\u003eSleepy Sleep\u003c\/a\u003e both contain magnesium too, and the 350 mg upper limit covers all your supplements combined. If your total goes past it, run the plan by your practitioner.\u003c\/p\u003e\n\u003ch3\u003eWhat does \"rice protein chelate\" mean?\u003c\/h3\u003e\n\u003cp\u003eIt's how the label names the magnesium source: magnesium bound to amino acids from rice protein. Chelates like this are grouped with the organic forms of magnesium, and in human studies organic forms such as amino acid chelates and citrate have generally shown greater absorption than magnesium oxide.\u003c\/p\u003e\n\u003ch3\u003eIs it safe to take with my medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner or pharmacist first. Magnesium can lower how well you absorb some antibiotics and bone medications, so doses may need spacing.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/best-magnesium-supplements-for-sleep-2026\"\u003eHow six magnesium products for sleep compare on dose, form, testing and price\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/calming-magnesium-powder-relax\"\u003eCalming Mag Powder, magnesium you mix into a drink\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/calm-sleep-stack-sleepy-passion-ht\"\u003eThe Calm + Sleep Stack: Sleepy Sleep, Relaxing Passion Flower and 5-HTP\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eJahnen-Dechent W et al. Magnesium basics. Clin Kidney J. 2012. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26069819\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003ePardo MR et al. Bioavailability of magnesium food supplements: A systematic review. Nutrition. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34111673\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWalker AF et al. Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study. Magnes Res. 2003. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14596323\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eZhang Y et al. Can Magnesium Enhance Exercise Performance? Nutrients. 2017. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28846654\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003ePickering G et al. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. 2020. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33260549\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSchuster J et al. Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled Trial. Nat Sci Sleep. 2025. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40918053\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":44364425888026,"sku":"015-A5006","price":21.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/A5006_REV00_Listing_Image_1.png?v=1738257832"},{"product_id":"b12-sublingual-essential-trio","title":"B-12 Essential Trio – B12, Folinate \u0026 B6 for Energy Metabolism | 2 fl oz Liquid","description":"\u003cp\u003e\u003cstrong\u003eB-12 Essential Trio is a blueberry-flavored liquid with three B vitamins. One serving (a single dropper bulb squeeze, about 0.84 grams) gives 2,000 mcg of vitamin B12 as methylcobalamin, 680 mcg DFE of folate as folinate and 4 mg of vitamin B6. Each 2 fl oz bottle holds 80 servings. Together, these vitamins support normal energy metabolism and healthy homocysteine metabolism.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB12 occurs naturally only in animal foods, so anyone eating little or no meat, fish, eggs or dairy may need another source. The NIH also advises people over 50 to get most of their B12 from fortified foods or supplements, since many older adults don't make enough stomach acid to free B12 from food (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-Consumer\/\"\u003ethe NIH's consumer guide to vitamin B12\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003eIf you're in your 30s or 40s and building habits so you can keep up at 75, half a dropper each morning is about as easy as a habit gets. No pills to swallow. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take B-12 Essential Trio\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports normal energy metabolism, because B12 and B6 are coenzymes your cells use to turn parts of protein and fat into fuel.†\u003c\/li\u003e\n\u003cli\u003eSupports healthy homocysteine levels already within the normal range, as B12 and folate recycle homocysteine into methionine.†\u003c\/li\u003e\n\u003cli\u003eSupports normal red blood cell formation and DNA synthesis, with folate and B12 working together.†\u003c\/li\u003e\n\u003cli\u003eSupports healthy nervous system function.†\u003c\/li\u003e\n\u003cli\u003eHelps people who eat few animal foods, and adults over 50, keep B12 intake up.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B6 (from Pyridoxine HCl)\u003c\/td\u003e\n\u003ctd\u003e4 mg\u003c\/td\u003e\n\u003ctd\u003e235%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFolinate (from Calcium Folinate)\u003c\/td\u003e\n\u003ctd\u003e680 mcg DFE\u003c\/td\u003e\n\u003ctd\u003e170%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B12 (Methylcobalamin)\u003c\/td\u003e\n\u003ctd\u003e2,000 mcg\u003c\/td\u003e\n\u003ctd\u003e83,333%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 1 Dropper Bulb Squeeze (Approximately half a dropper full, Approximately 0.84 grams). Servings per container: 80. Other ingredients: Vegetable Glycerin, Purified Water, Citric Acid, Potassium Sorbate, and Natural Blueberry Flavor. The label states: \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or artificial colors or flavors.\" It also says: \"Refrigerate after opening.\" Potassium sorbate is a preservative.\u003c\/p\u003e\n\u003ch2\u003eHow B-12 Essential Trio works\u003c\/h2\u003e\n\u003ch3\u003eMethylcobalamin (2,000 mcg): B12 for the methylation cycle\u003c\/h3\u003e\n\u003cp\u003eB12 is a coenzyme, a helper molecule two enzymes can't work without, and methylcobalamin is one of the two forms your cells use in that role (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B12\u003c\/a\u003e). It partners with methionine synthase, the enzyme that recycles homocysteine into methionine, which your body turns into SAMe, its most important methyl donor. That same step pulls a one-carbon unit off folate so folate can keep cycling into DNA building blocks, which is why B12 and folate come as a pair. B12's other coenzyme form helps your mitochondria turn leftovers from breaking down certain amino acids into fuel (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\"\u003eFroese et al., 2019\u003c\/a\u003e).†\u003c\/p\u003e\n\u003cp\u003eStraight talk: your cells process any B12 they absorb before using it, and the NIH says there's no evidence that absorption differs by form. We chose methylcobalamin because it's one of the two coenzyme forms, not because we can show it's absorbed or used better.\u003c\/p\u003e\n\u003ch3\u003eWhy 2,000 mcg when the Daily Value is 2.4 mcg\u003c\/h3\u003e\n\u003cp\u003eBecause the share you absorb drops as the dose rises: the NIH puts absorption near 50% for doses under 1 to 2 mcg but about 1.3% of a 1,000 mcg dose. A systematic review saw the same pattern with food: people absorbed 83% of a 3 mcg dose but only 4.5% of a 38 mcg dose (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23796635\/\"\u003eDoets et al., 2013\u003c\/a\u003e). A big dose offsets a small percentage.\u003c\/p\u003e\n\u003ch3\u003eFolinate (680 mcg DFE): folate that skips a slow step\u003c\/h3\u003e\n\u003cp\u003eFolate carries the one-carbon units your cells need to build DNA and keep the methionine cycle turning.† Most supplements use folic acid, a fully oxidized form your body must first convert with an enzyme called DHFR; food folates are already in the reduced tetrahydrofolate form (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Folate-HealthProfessional\/\"\u003eNIH fact sheet on folate\u003c\/a\u003e). In liver tissue from six people, DHFR converted folic acid at less than 2% of the rate seen in rat liver, and activity varied almost fivefold between people (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19706381\/\"\u003eBailey and Ayling, 2009\u003c\/a\u003e). Folinate is a formyl form of tetrahydrofolate, the same reduced family as food folate, so it doesn't wait on DHFR. To be fair, that was a lab study, not a supplement trial, and the NIH puts folic acid absorption at about 85% with food. Folinate just takes one step out of the way.\u003c\/p\u003e\n\u003ch3\u003eVitamin B6 (4 mg from pyridoxine HCl): the protein-metabolism helper\u003c\/h3\u003e\n\u003cp\u003eYour body turns pyridoxine into pyridoxal 5' phosphate (PLP), the coenzyme form of B6, which takes part in more than 100 enzyme reactions, mostly in protein metabolism (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB6-HealthProfessional\/\"\u003eNIH fact sheet on vitamin B6\u003c\/a\u003e).† One review names B6, B12 and folate as the B vitamins most involved in homocysteine metabolism, and describes the B group's roles in energy production, DNA synthesis and making the brain's chemical messengers (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003eKennedy, 2016\u003c\/a\u003e).† Pyridoxine HCl is the most common B6 form in supplements; if you want B6 already in coenzyme form, that's \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/p5p-50mg-vitamin-b6-supplement\"\u003eour P5P 50 mg\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eWhat the research does and doesn't show\u003c\/h3\u003e\n\u003cp\u003eWhat it shows: a pooled analysis of 25 randomized trials with 2,596 participants found folic acid reduced blood homocysteine by 13% to 25%, depending on dose; B12 (0.4 mg a day) brought it down about 7% more, and B6 had no significant effect (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16210710\/\"\u003eHomocysteine Lowering Trialists' Collaboration, 2005\u003c\/a\u003e). Those trials used folic acid, not folinate, and none tested this product.\u003c\/p\u003e\n\u003cp\u003eWhat it doesn't show: that B vitamins sharpen your thinking. A systematic review of 14 randomized trials found no clear effect of B6, B12 or folic acid on cognitive test scores, and most trials were small or low quality (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17210874\/\"\u003eBalk et al., 2007\u003c\/a\u003e). We haven't run a trial on B-12 Essential Trio itself; what we can show you is what's in each serving and how every lot is tested.\u003c\/p\u003e\n\u003ch2\u003eHow to take B-12 Essential Trio\u003c\/h2\u003e\n\u003cp\u003eThe label directions, word for word: \"Take one serving by mouth in the morning.\" One serving is a single squeeze of the dropper bulb, which fills about half the dropper.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSqueeze the bulb once, release, and drip the liquid into your mouth, or into a little water or juice.\u003c\/li\u003e\n\u003cli\u003eRefrigerate after opening, as the label says.\u003c\/li\u003e\n\u003cli\u003eAt one serving each morning, a bottle's 80 servings last 80 days.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. The label gives no serving for children, so check with your child's practitioner first. Acid-reducing medicines can make it harder to absorb B12 from food.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. Fifty-two years in, here's how we back up this label:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the methylcobalamin, folinate and B6 included, for identity, potency, heavy metals and microbes. Here's \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/our-approach-to-raw-material-sourcing-and-testing\"\u003ehow we source and test raw materials\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/b12-sublingual-essential-trio\"\u003eSee the certificates of analysis for this product\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e B-12 Essential Trio is made in our UL-certified cGMP facility in Mt. Angel, a farm town of about 3,500 in the Willamette Valley. The people who formulate, make and test it work under one roof, and the owners work in the building too. We're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much B12, folate and B6 is in one serving?\u003c\/h3\u003e\n\u003cp\u003eOne serving has 2,000 mcg of vitamin B12 as methylcobalamin (83,333% of the Daily Value), 680 mcg DFE of folate as folinate (170%) and 4 mg of vitamin B6 from pyridoxine HCl (235%).\u003c\/p\u003e\n\u003ch3\u003eIs B-12 Essential Trio a sublingual B12?\u003c\/h3\u003e\n\u003cp\u003eYou can take it that way; the label simply says to take one serving by mouth in the morning. Holding it under your tongue first is fine, though the NIH says evidence suggests no difference in efficacy between oral and sublingual B12.\u003c\/p\u003e\n\u003ch3\u003eIs 2,000 mcg of B12 too much?\u003c\/h3\u003e\n\u003cp\u003eIt's a large dose, but no upper limit has been set for vitamin B12 because of its low potential for toxicity, and you absorb only a small share of it. The 4 mg of B6 is well under the 100 mg adult upper limit. If you take medication, check with your practitioner first.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with B-Complex or Triple B-12 Dots?\u003c\/h3\u003e\n\u003cp\u003eCheck the totals first, because they overlap. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b-good-com-vitamin-b-complex\"\u003eOur B-Complex with all eight B vitamins\u003c\/a\u003e already has 100 mg of B6 per capsule, so adding B-12 Essential Trio brings B6 to 104 mg a day, just over the 100 mg adult upper limit. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-dots-energy-nervous-support\"\u003eTriple B-12 Dots\u003c\/a\u003e add 1,000 mcg of B12 per dot, which you likely don't need on top of 2,000 mcg. Most people pick one, or ask a practitioner first.\u003c\/p\u003e\n\u003ch3\u003eHow soon will I notice a difference?\u003c\/h3\u003e\n\u003cp\u003eThere's no jolt, because B vitamins aren't stimulants; they keep enzymes supplied. If your intake was already good, you may not feel a difference at all, and that's normal.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eFroese DS et al. Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDoets EL et al. Systematic review on daily vitamin B12 losses and bioavailability for deriving recommendations on vitamin B12 intake with the factorial approach. Ann Nutr Metab. 2013. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23796635\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBailey SW et al. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci U S A. 2009. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19706381\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828517\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHomocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16210710\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBalk EM et al. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch Intern Med. 2007. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17210874\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"1","offer_id":44364424479002,"sku":"015-M2210","price":25.99,"currency_code":"USD","in_stock":true},{"title":"3","offer_id":44900315201818,"sku":"015-M2210-3","price":69.99,"currency_code":"USD","in_stock":true},{"title":"5","offer_id":44900315234586,"sku":"015-M2210-5","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M2210_REV02_Box.png?v=1738258018"},{"product_id":"womens-multi-cap-60ct","title":"Women’s Multi with KSM-66® Ashwagandha – Energy \u0026 Stress Support | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eWomen's Multi is a daily multivitamin for women with 23 vitamins and minerals, 300 mg of KSM-66® ashwagandha extract and 50 mg of CoQ10 in each 2-capsule serving. It uses methylcobalamin (B12), calcium folinate, vitamin D3 and vitamin K2 as MK-7. One bottle holds 60 capsules, or 30 servings. It helps fill everyday nutrient gaps and supports a healthy response to stress.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis one is for women in their 30s and 40s who are already doing the work: moving most days, eating vegetables on purpose, sleeping when the week allows. Food rarely covers everything every day, and the stretch between the 7 a.m. alarm and the 4 p.m. meeting isn't kind to your stress levels. Women's Multi is the foundation layer, with active forms where the form matters and an adaptogen for the busy part. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974, and a solid daily multi is still the first bottle we'd put in your cabinet.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Women's Multi\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe daily basics.\u003c\/strong\u003e 13 vitamins and 10 minerals help fill the gaps a busy week leaves in your diet.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA steadier response to stress.\u003c\/strong\u003e 300 mg of KSM-66® ashwagandha supports a healthy response to everyday stress.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEveryday energy.\u003c\/strong\u003e All eight B vitamins help your body turn food into energy, and 50 mg of CoQ10 supports cellular energy production.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNormal immune function.\u003c\/strong\u003e Vitamins A, C and D, zinc and selenium support normal immune function.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBones you'll want later.\u003c\/strong\u003e Vitamin D3 and vitamin K2 (MK-7) support healthy bones.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant support.\u003c\/strong\u003e Vitamins C and E and selenium support the body's antioxidant defenses.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin A (palmitate)\u003c\/td\u003e\n\u003ctd\u003e750 mcg RAE\u003c\/td\u003e\n\u003ctd\u003e83%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin C (calcium ascorbate)\u003c\/td\u003e\n\u003ctd\u003e120 mg\u003c\/td\u003e\n\u003ctd\u003e133%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin D (cholecalciferol)\u003c\/td\u003e\n\u003ctd\u003e25 mcg\u003c\/td\u003e\n\u003ctd\u003e125%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin E (natural d,alpha-tocopherol)\u003c\/td\u003e\n\u003ctd\u003e20 mg\u003c\/td\u003e\n\u003ctd\u003e133%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin K (K2, menaquinone MK7)\u003c\/td\u003e\n\u003ctd\u003e80 mcg\u003c\/td\u003e\n\u003ctd\u003e66%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eThiamin (thiamin mononitrate)\u003c\/td\u003e\n\u003ctd\u003e5 mg\u003c\/td\u003e\n\u003ctd\u003e416%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRiboflavin\u003c\/td\u003e\n\u003ctd\u003e5 mg\u003c\/td\u003e\n\u003ctd\u003e384%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNiacinamide\u003c\/td\u003e\n\u003ctd\u003e50 mg NE\u003c\/td\u003e\n\u003ctd\u003e312%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B6 (pyridoxine HCl)\u003c\/td\u003e\n\u003ctd\u003e5 mg\u003c\/td\u003e\n\u003ctd\u003e294%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFolate (calcium folinate)\u003c\/td\u003e\n\u003ctd\u003e680 mcg DFE\u003c\/td\u003e\n\u003ctd\u003e170%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B12 (methylcobalamin)\u003c\/td\u003e\n\u003ctd\u003e25 mcg\u003c\/td\u003e\n\u003ctd\u003e1,041%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBiotin\u003c\/td\u003e\n\u003ctd\u003e1,000 mcg\u003c\/td\u003e\n\u003ctd\u003e3,333%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePantothenic Acid (d-calcium pantothenate)\u003c\/td\u003e\n\u003ctd\u003e20 mg\u003c\/td\u003e\n\u003ctd\u003e400%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium (calcium ascorbate)\u003c\/td\u003e\n\u003ctd\u003e13 mg\u003c\/td\u003e\n\u003ctd\u003e1%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIodine (from Laminaria digitata)\u003c\/td\u003e\n\u003ctd\u003e150 mcg\u003c\/td\u003e\n\u003ctd\u003e100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium (amino acid chelate)\u003c\/td\u003e\n\u003ctd\u003e20 mg\u003c\/td\u003e\n\u003ctd\u003e4%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (L-zinc methionine)\u003c\/td\u003e\n\u003ctd\u003e15 mg\u003c\/td\u003e\n\u003ctd\u003e136%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSelenium (L-selenomethionine)\u003c\/td\u003e\n\u003ctd\u003e50 mcg\u003c\/td\u003e\n\u003ctd\u003e90%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCopper (gluconate)\u003c\/td\u003e\n\u003ctd\u003e1 mg\u003c\/td\u003e\n\u003ctd\u003e111%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eManganese (citrate)\u003c\/td\u003e\n\u003ctd\u003e2 mg\u003c\/td\u003e\n\u003ctd\u003e86%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChromium (amino acid chelate)\u003c\/td\u003e\n\u003ctd\u003e120 mcg\u003c\/td\u003e\n\u003ctd\u003e342%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolybdenum (amino acid chelate)\u003c\/td\u003e\n\u003ctd\u003e75 mcg\u003c\/td\u003e\n\u003ctd\u003e166%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePotassium (citrate)\u003c\/td\u003e\n\u003ctd\u003e40 mg\u003c\/td\u003e\n\u003ctd\u003e\u0026lt;1%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWithania somnifera Extract (from KSM-66® Ashwagandha)\u003c\/td\u003e\n\u003ctd\u003e300 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCoenzyme Q10\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLutein (natural)\u003c\/td\u003e\n\u003ctd\u003e1 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eProprietary Blend\u003c\/td\u003e\n\u003ctd\u003e200 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 2 capsules. Servings per container: 30. *Daily Value not established. Proprietary Blend contains: Ginger, Bilberry Fruit Extract (from Vaccinium myrtillus, standardized to 25% anthocyanosides), Acai Berry, Camu Camu Berry, Goji Berry, Mangosteen Fruit, Maqui Fruit, Broccoli, Broccoli Sprouts, Tomato, Carrot, Spinach, Kale, Lycopene (natural), and Zeaxanthin. Other ingredients: Vegetable cellulose (preservative-free, from capsule shell), stearic acid, silicon dioxide. KSM-66® is a registered trademark of Ixoreal Biomed Inc. The bottle shows a gluten-free icon, and the Supplement Facts graphic adds dairy-free and soy-free icons.\u003c\/p\u003e\n\u003ch2\u003eHow Women's Multi works\u003c\/h2\u003e\n\u003ch3\u003eB vitamins, two in active forms\u003c\/h3\u003e\n\u003cp\u003eB vitamins help your cells turn food into usable energy.† B12 comes as methylcobalamin, one of the two coenzyme forms of B12 your body uses. Folate comes as calcium folinate (folinic acid), a reduced folate that enters the folate cycle without the conversion step folic acid needs. Folic acid works for most people; folinate simply skips that step. At 3,333% of the Daily Value, \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Biotin-HealthProfessional\/\"\u003ebiotin can cause falsely high or low lab results\u003c\/a\u003e, so mention it before blood work.\u003c\/p\u003e\n\u003ch3\u003eVitamin D3 and vitamin K2 (MK-7)\u003c\/h3\u003e\n\u003cp\u003eVitamin D comes as D3 (cholecalciferol), 25 mcg (1,000 IU). \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22552031\/\"\u003eA meta-analysis of randomized trials comparing D2 and D3\u003c\/a\u003e found D3 raised blood vitamin D levels more effectively, though the gap was clearest with large, infrequent doses and wasn't significant with daily dosing.\u003c\/p\u003e\n\u003cp\u003eVitamin K comes as K2 in the MK-7 form, 80 mcg. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17158229\/\"\u003ea study in healthy volunteers comparing K1 and MK-7\u003c\/a\u003e, both were absorbed well, but MK-7 stayed in the blood far longer, built up to 7 to 8 times higher levels during prolonged daily intake, and more fully activated osteocalcin, a vitamin K-dependent bone protein. D3 and K2 support healthy bones.†\u003c\/p\u003e\n\u003ch3\u003eVitamins A, C and E, and the minerals\u003c\/h3\u003e\n\u003cp\u003eVitamin C is calcium ascorbate, a buffered, less acidic form and the source of the 13 mg of calcium. Vitamin E is d-alpha-tocopherol, the naturally sourced form. Most minerals are bound to amino acids or citrate, like zinc as L-zinc methionine and selenium as L-selenomethionine, and iodine comes from Laminaria digitata, a brown seaweed.\u003c\/p\u003e\n\u003cp\u003eNow the candid part. It takes hundreds of milligrams of calcium, magnesium or potassium to make a real dent, and that won't fit in two capsules. So you get 13 mg of calcium, 20 mg of magnesium, 40 mg of potassium and no iron. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29211007\/\"\u003eAn analysis of survey data on 10,698 US adults\u003c\/a\u003e notes that dietary guidelines list all four as under-consumed, and found supplement users had higher intakes of 15 to 16 of 19 nutrients (intake data, not health outcomes). Want more magnesium? \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/good-magnesium-chelate-amino-acids\"\u003eGood Magnesium adds 200 mg per capsule\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eKSM-66® ashwagandha\u003c\/h3\u003e\n\u003cp\u003eAshwagandha (Withania somnifera) is an Ayurvedic herb often called an adaptogen, meaning one taken to help the body handle stress. KSM-66® is a branded ashwagandha extract, 300 mg per serving. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38140274\/\"\u003eA 2023 systematic review of 9 trials in stressed adults\u003c\/a\u003e found ashwagandha lowered cortisol, the body's main stress hormone, without significant side effects. The limits: the trials varied in extract, dose and length (30 to 112 days), and none tracked long-term effects. Encouraging, not settled. KSM-66® supports a healthy response to everyday stress.†\u003c\/p\u003e\n\u003ch3\u003eCoenzyme Q10\u003c\/h3\u003e\n\u003cp\u003eYour cells make CoQ10 and use it in their mitochondria to produce energy; it also works as an antioxidant. Each serving has 50 mg. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16551570\/\"\u003eA review of how CoQ10 is absorbed\u003c\/a\u003e describes a large, fat-soluble molecule with slow, limited absorption, a blood peak about 6 hours after a dose and a half-life of about 33 hours. Translation: daily consistency matters more than the exact hour. CoQ10 supports cellular energy production.†\u003c\/p\u003e\n\u003ch3\u003eLutein and the plant blend\u003c\/h3\u003e\n\u003cp\u003eYou also get 1 mg of lutein and the 200 mg plant blend listed above. Straight math: 200 mg shared by 15 ingredients averages about 13 mg each, so think of it as a sprinkle, not a stand-in for vegetables. We don't make eye or heart claims for it.\u003c\/p\u003e\n\u003ch2\u003eHow to take Women's Multi\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDirections from the label:\u003c\/strong\u003e \"As a dietary supplement, take two capsules daily.\"\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe label doesn't mention food; since vitamins A, D, E and K and CoQ10 are fat-soluble, a meal is a reasonable default.\u003c\/li\u003e\n\u003cli\u003eCount your vitamin D across products. This serving has 25 mcg (1,000 IU); the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/\"\u003eNIH upper limit for adults is 100 mcg (4,000 IU) a day\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003eOn a blood thinner? \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminK-HealthProfessional\/\"\u003eVitamin K can interact with warfarin and similar anticoagulants\u003c\/a\u003e, and the MK-7 study above noted that 50 mcg a day or more may interfere with them. This serving has 80 mcg.\u003c\/li\u003e\n\u003cli\u003eThe \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Ashwagandha-HealthProfessional\/\"\u003eNIH fact sheet on ashwagandha\u003c\/a\u003e notes it was well tolerated in trials for up to about 3 months, long-term safety isn't known, there are a few reports of liver side effects, it might affect thyroid function and interact with some medications, and some experts advise against it in pregnancy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming lot for identity, potency, heavy metals and microbes, all the way down a multivitamin's long ingredient list.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of Women's Multi has one.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA with globally sourced ingredients, in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley. Our formulators, makers and testers work under one roof in a UL-certified cGMP facility, and the owners work in the building too. We've been making supplements in Oregon for 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow many capsules of Women's Multi do I take?\u003c\/h3\u003e\n\u003cp\u003eTwo capsules daily, as the label directs. That's one serving, so a 60-capsule bottle lasts 30 days.\u003c\/p\u003e\n\u003ch3\u003eWho is Women's Multi for?\u003c\/h3\u003e\n\u003cp\u003eAdult women, especially in their 30s and 40s, who want stress support built into their multi. Over 50? \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/womens-50-plus-multivitamin\"\u003eWomen's 50+ Multivitamin\u003c\/a\u003e has the same 300 mg of KSM-66® with 100 mg of CoQ10, 10 mg of lutein and 2 mg of zeaxanthin. It isn't a prenatal; if you're pregnant or trying, talk with your practitioner and see \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/my-prenatal-complete-nutrition\"\u003eour prenatal formula, My Prenatal\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eDoes Women's Multi contain iron or calcium?\u003c\/h3\u003e\n\u003cp\u003eNo iron, and only 13 mg of calcium (1% DV). A meaningful amount of either won't fit in two capsules alongside everything else.\u003c\/p\u003e\n\u003ch3\u003eHow long until I notice anything?\u003c\/h3\u003e\n\u003cp\u003eThere's no set timeline. Vitamins and minerals work quietly, so you may not \"feel\" them at all, and the ashwagandha trials in the 2023 review ran 30 to 112 days. Give it at least a month of daily use before you judge.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with other Mt. Angel Vitamins products?\u003c\/h3\u003e\n\u003cp\u003eUsually, if you add up overlaps, especially vitamin D. For more CoQ10, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/coq10-alpha-lipoic-acid\"\u003eCoQ10 100 mg + Alpha Lipoic Acid\u003c\/a\u003e adds 100 mg per capsule.\u003c\/p\u003e\n\u003ch3\u003eIs it safe to take with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your practitioner first. Vitamin K2 can interact with warfarin-type blood thinners, biotin can skew some lab tests, and ashwagandha may interact with some medications.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eTripkovic L et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22552031\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSchurgers LJ et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17158229\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBlumberg JB et al. Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Nutrients. 2017. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29211007\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDella Porta M et al. Effects of Withania somnifera on Cortisol Levels in Stressed Human Subjects: A Systematic Review. Nutrients. 2023. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38140274\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBhagavan HN, Chopra RK. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16551570\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":44364423954714,"sku":"015-M4001","price":47.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M4001_REV02_Listing_Image_1.png?v=1738258502"},{"product_id":"mens-multi-vitamin-60-capsules","title":"Men's Multi With KSM-66 Ashwagandha \u0026 CoQ10 – Energy Support | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eMen's Multi is a daily multivitamin for men: two capsules give you 13 vitamins and 10 minerals, including vitamin D3 (12.5 mcg), vitamin K2 as MK-7 (80 mcg) and methylcobalamin B12, plus 300 mg of KSM-66® ashwagandha extract and 50 mg of CoQ10. 60 capsules, a 30-day supply. It supports energy metabolism, normal immune function and a healthy response to everyday stress.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIt's for the guy in his 30s or 40s who would like his 70s to look a lot like his 40s. You already know the basics: sleep, lift something heavy, eat a vegetable now and then. Men's Multi helps fill the gaps a busy diet leaves, then adds ashwagandha and CoQ10 so one bottle does more of the work. Aging isn't optional. Getting old is. (Over 50? See \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mens-50-plus-multivitamin\"\u003eMen's 50+ Multivitamin, built for men over 50\u003c\/a\u003e.)\u003c\/p\u003e\n\u003ch2\u003eWhy people take Men's Multi\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEveryday nutrient gaps.\u003c\/strong\u003e 13 vitamins and 10 minerals, with 9 of the 13 vitamins at or above 100% of the Daily Value.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy metabolism.\u003c\/strong\u003e B vitamins help turn food into usable energy, and CoQ10 helps your mitochondria make it.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEveryday stress.\u003c\/strong\u003e 300 mg of KSM-66® ashwagandha to support a healthy response to everyday stress.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNormal immune function.\u003c\/strong\u003e Vitamins A, C and D plus zinc and selenium.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant support.\u003c\/strong\u003e Vitamins C and E, selenium, and a blend with lycopene, lutein and zeaxanthin.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin A (palmitate)\u003c\/td\u003e\n\u003ctd\u003e750 mcg RAE\u003c\/td\u003e\n\u003ctd\u003e83%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin C (calcium ascorbate)\u003c\/td\u003e\n\u003ctd\u003e120 mg\u003c\/td\u003e\n\u003ctd\u003e133%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin D (cholecalciferol)\u003c\/td\u003e\n\u003ctd\u003e12.5 mcg\u003c\/td\u003e\n\u003ctd\u003e63%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin E (natural d,alpha-tocopherol)\u003c\/td\u003e\n\u003ctd\u003e20 mg\u003c\/td\u003e\n\u003ctd\u003e133%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin K (K2, menaquinone MK7)\u003c\/td\u003e\n\u003ctd\u003e80 mcg\u003c\/td\u003e\n\u003ctd\u003e66%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eThiamin (thiamin mononitrate)\u003c\/td\u003e\n\u003ctd\u003e5 mg\u003c\/td\u003e\n\u003ctd\u003e416%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRiboflavin\u003c\/td\u003e\n\u003ctd\u003e5 mg\u003c\/td\u003e\n\u003ctd\u003e384%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNiacin\u003c\/td\u003e\n\u003ctd\u003e25 mg NE\u003c\/td\u003e\n\u003ctd\u003e156%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNiacinamide\u003c\/td\u003e\n\u003ctd\u003e25 mg NE\u003c\/td\u003e\n\u003ctd\u003e156%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B6 (pyridoxine HCl)\u003c\/td\u003e\n\u003ctd\u003e5 mg\u003c\/td\u003e\n\u003ctd\u003e294%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFolate (from Calcium Folinate)\u003c\/td\u003e\n\u003ctd\u003e340 mcg DFE\u003c\/td\u003e\n\u003ctd\u003e85%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin B12 (methylcobalamin)\u003c\/td\u003e\n\u003ctd\u003e25 mcg\u003c\/td\u003e\n\u003ctd\u003e1,041%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBiotin\u003c\/td\u003e\n\u003ctd\u003e300 mcg\u003c\/td\u003e\n\u003ctd\u003e1,000%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePantothenic Acid (d-calcium pantothenate)\u003c\/td\u003e\n\u003ctd\u003e10 mg\u003c\/td\u003e\n\u003ctd\u003e200%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium (calcium ascorbate)\u003c\/td\u003e\n\u003ctd\u003e13 mg\u003c\/td\u003e\n\u003ctd\u003e1%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIodine (from \u003cem\u003eLaminaria digitata\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e150 mcg\u003c\/td\u003e\n\u003ctd\u003e100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium (amino acid chelate)\u003c\/td\u003e\n\u003ctd\u003e20 mg\u003c\/td\u003e\n\u003ctd\u003e4%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (L-zinc methionine)\u003c\/td\u003e\n\u003ctd\u003e15 mg\u003c\/td\u003e\n\u003ctd\u003e136%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSelenium (L-selenomethionine)\u003c\/td\u003e\n\u003ctd\u003e70 mcg\u003c\/td\u003e\n\u003ctd\u003e127%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCopper (gluconate)\u003c\/td\u003e\n\u003ctd\u003e1 mg\u003c\/td\u003e\n\u003ctd\u003e111%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eManganese (citrate)\u003c\/td\u003e\n\u003ctd\u003e2 mg\u003c\/td\u003e\n\u003ctd\u003e86%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChromium (amino acid chelate)\u003c\/td\u003e\n\u003ctd\u003e120 mcg\u003c\/td\u003e\n\u003ctd\u003e342%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolybdenum (amino acid chelate)\u003c\/td\u003e\n\u003ctd\u003e75 mcg\u003c\/td\u003e\n\u003ctd\u003e166%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePotassium (citrate)\u003c\/td\u003e\n\u003ctd\u003e40 mg\u003c\/td\u003e\n\u003ctd\u003e\u0026lt;1%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eWithania somnifera\u003c\/em\u003e Extract (from KSM-66® Ashwagandha)\u003c\/td\u003e\n\u003ctd\u003e300 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCoenzyme Q10\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eProprietary Blend\u003c\/td\u003e\n\u003ctd\u003e172 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*Daily Value not established.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing size:\u003c\/strong\u003e 2 Capsules. \u003cstrong\u003eServings per container:\u003c\/strong\u003e 30. \u003cstrong\u003eProprietary Blend contains:\u003c\/strong\u003e Ginger, Bilberry Fruit Extract (from \u003cem\u003eVaccinium myrtillus\u003c\/em\u003e, standardized to 25% anthocyanosides), Acai Berry, Camu Camu Berry, Goji Berry, Mangosteen, Maqui, Broccoli, Broccoli Sprouts, Tomato, Carrot, Spinach, and Kale, Lutein (natural), Lycopene, and Zeaxanthin (natural). \u003cstrong\u003eOther ingredients:\u003c\/strong\u003e Vegetable cellulose (preservative-free, from capsule shell), stearic acid (vegetable source), silicon dioxide. KSM-66® is a registered trademark of Ixoreal Biomed Inc.\u003c\/p\u003e\n\u003ch2\u003eHow Men's Multi works\u003c\/h2\u003e\n\u003cp\u003eWhy a multi at all? In US survey data from 2007 to 2010, 74% of Americans got less than the average requirement for vitamin D, 67% for vitamin E and 46% for magnesium, even counting food and multivitamins (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24724766\/\"\u003eWallace et al., 2014\u003c\/a\u003e). A multi fills gaps. It doesn't replace dinner.\u003c\/p\u003e\n\u003ch3\u003eB vitamins, including methyl B12 and folinate\u003c\/h3\u003e\n\u003cp\u003eB vitamins help turn carbs, fat and protein into energy your cells can use.† The B12 is methylcobalamin, one of the two forms of B12 your body actually puts to work. Folate comes from calcium folinate, which is already in its reduced form, so it skips the enzyme step folic acid needs first. Candid note: the B6 is pyridoxine HCl, the standard form, not P5P. If 1,041% of the Daily Value for B12 looks like a lot: no upper limit was set for B12, given its low potential for toxicity (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/\"\u003eNIH B12 fact sheet\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eVitamin D3 and vitamin K2 (MK-7)\u003c\/h3\u003e\n\u003cp\u003eVitamin D supports normal bone, muscle and immune function.† This is D3, 12.5 mcg (500 IU). A meta-analysis of head-to-head trials found D3 raised blood vitamin D more than D2 overall, though the edge came from large, infrequent doses and was not significant when the doses were daily (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22552031\/\"\u003eTripkovic et al., 2012\u003c\/a\u003e). Vitamin K activates osteocalcin, a protein your bones use to bind calcium.† The K2 is MK-7: in healthy volunteers it stayed in the blood far longer than vitamin K1 and built to 7 to 8 times higher levels with daily use (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17158229\/\"\u003eSchurgers et al., 2007\u003c\/a\u003e). If your practitioner wants you on more of both, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/everyday-liquid-sunshine-2-d3-k2\"\u003eEveryday Liquid Sunshine 2, our liquid D3 + K2\u003c\/a\u003e is the add-on; see the FAQ on vitamin D totals first.\u003c\/p\u003e\n\u003ch3\u003eVitamins A, C and E\u003c\/h3\u003e\n\u003cp\u003eVitamin A is preformed palmitate. Vitamin C is calcium ascorbate, a buffered form that also supplies the label's 13 mg of calcium. Vitamin E is natural d-alpha-tocopherol, and the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminE-HealthProfessional\/\"\u003eNIH vitamin E fact sheet\u003c\/a\u003e counts 1 mg of the natural form as equal to 2 mg of the synthetic one. C and E support your antioxidant defenses.†\u003c\/p\u003e\n\u003ch3\u003eMinerals, half of them bound to amino acids\u003c\/h3\u003e\n\u003cp\u003eZinc is bound to methionine, selenium is L-selenomethionine, and magnesium, chromium and molybdenum are amino acid chelates. Copper is there too, which matters because zinc and copper compete for absorption. Iodine (150 mcg) from the kelp \u003cem\u003eLaminaria digitata\u003c\/em\u003e supports normal thyroid function.† Straight talk: magnesium (4% DV), calcium (1%) and potassium (under 1%) are small, because a full day of those bulky minerals won't fit in two capsules. Given how many people fall short on magnesium, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/good-magnesium-chelate-amino-acids\"\u003eGood Magnesium, our chelated magnesium\u003c\/a\u003e is the easy add.\u003c\/p\u003e\n\u003ch3\u003eKSM-66® ashwagandha (300 mg)\u003c\/h3\u003e\n\u003cp\u003eAshwagandha (\u003cem\u003eWithania somnifera\u003c\/em\u003e) is an herb from Ayurvedic tradition, usually called an adaptogen: it helps the body handle everyday stress.† KSM-66® is a branded ashwagandha extract. In an 8-week trial, 57 men aged 18 to 50 with little lifting experience started a weight-training program and took either 300 mg of ashwagandha root extract twice a day or a placebo; bench press strength rose 46 kg with ashwagandha versus 26 kg with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26609282\/\"\u003eWankhede et al., 2015\u003c\/a\u003e). A review pooling 12 trials in healthy men and women found ashwagandha beat placebo on physical performance measures such as strength, fitness and recovery, and said more comparable studies are needed (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33670194\/\"\u003eBonilla et al., 2021\u003c\/a\u003e). In a 90-day trial in 130 healthy, stressed adults, 300 mg a day of a different, slow-release root extract lowered perceived stress scores and improved sleep quality scores versus placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34858513\/\"\u003eGopukumar et al., 2021\u003c\/a\u003e). What it doesn't show: the strength trial used 600 mg a day, twice this serving, and these trials are small and short.\u003c\/p\u003e\n\u003ch3\u003eCoQ10 (50 mg)\u003c\/h3\u003e\n\u003cp\u003eYour body makes coenzyme Q10 on its own. It passes electrons along the chain in your mitochondria that produces ATP, the energy currency of every cell, and acts as a fat-soluble antioxidant in cell membranes.† 50 mg is a daily base; \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/coq10-alpha-lipoic-acid\"\u003eCoQ10 + Alpha Lipoic Acid\u003c\/a\u003e carries more.\u003c\/p\u003e\n\u003ch3\u003eThe fruit, vegetable and carotenoid blend (172 mg)\u003c\/h3\u003e\n\u003cp\u003eSixteen ingredients: thirteen plant ingredients, from ginger and bilberry extract to broccoli sprouts and kale, and three carotenoids, lycopene (the red carotenoid in tomatoes) and lutein and zeaxanthin (yellow carotenoids that collect in the eye). Honest math: 172 mg split 16 ways is a little of each, and the label doesn't list individual amounts. It adds antioxidant variety.† It is not a serving of vegetables.\u003c\/p\u003e\n\u003ch2\u003eHow to take Men's Multi\u003c\/h2\u003e\n\u003cp\u003eThe label says: \"As a dietary supplement, take two capsules daily.\" That's one serving, so a bottle lasts 30 days.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOn a blood thinner?\u003c\/strong\u003e The MK-7 researchers above noted that 50 mcg a day or more of MK-7 may interfere with oral anticoagulants. This has 80 mcg, so talk to your practitioner first.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGetting blood work?\u003c\/strong\u003e Mention the biotin. Biotin above recommended intakes can cause falsely high or low lab results (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Biotin-HealthProfessional\/\"\u003eNIH biotin fact sheet\u003c\/a\u003e).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAbout ashwagandha.\u003c\/strong\u003e Common side effects (loose stools, nausea, drowsiness) are usually mild, there are a few reports of more serious side effects, including effects on liver function, and it might affect thyroid function or interact with some medications (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Ashwagandha-HealthProfessional\/\"\u003eNIH ashwagandha fact sheet\u003c\/a\u003e).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRead the full label on your bottle before use. Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming lot, from the vitamins to the ashwagandha, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Each one records that lot's test results.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon, with globally sourced ingredients.\u003c\/strong\u003e It's a farm town of about 3,500 in the Willamette Valley. Men's Multi is made in our UL-certified cGMP facility, where the formulators, the people who make it and the people who test it work under one roof. The owners work in the building too, and have run the place since 2017.\u003c\/p\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow many Men's Multi capsules do I take a day?\u003c\/h3\u003e\n\u003cp\u003eTwo. The label says to take two capsules daily, which is one serving, so a 60-capsule bottle is a 30-day supply.\u003c\/p\u003e\n\u003ch3\u003eShould I take Men's Multi with food?\u003c\/h3\u003e\n\u003cp\u003eThe label doesn't say, but a meal with some fat is a good habit for the fat-soluble vitamins and CoQ10.\u003c\/p\u003e\n\u003ch3\u003eHow long until I notice a difference?\u003c\/h3\u003e\n\u003cp\u003eGive it at least two months. A multi mostly works quietly, filling gaps, and the ashwagandha trials above measured results after 8 weeks to 90 days of daily use.\u003c\/p\u003e\n\u003ch3\u003eShould I choose Men's Multi or Men's 50+?\u003c\/h3\u003e\n\u003cp\u003eUnder 50, start with Men's Multi. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mens-50-plus-multivitamin\"\u003eMen's 50+ Multivitamin\u003c\/a\u003e shares most of the same vitamins, minerals and 300 mg of KSM-66®, but doubles the vitamin D (25 mcg), pantothenic acid (20 mg), selenium (140 mcg) and CoQ10 (100 mg), and lists lutein (10 mg) and zeaxanthin (2 mg) as their own ingredients instead of inside a blend.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with Everyday Liquid Sunshine 2, B-12 Essential Trio or my medication?\u003c\/h3\u003e\n\u003cp\u003eCheck your totals and ask your practitioner first. One serving of Everyday Liquid Sunshine 2 has 125 mcg (5,000 IU) of vitamin D3, so together with this multi you would be above the 100 mcg (4,000 IU) daily upper limit for adults on the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/\"\u003eNIH vitamin D fact sheet\u003c\/a\u003e. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/b12-sublingual-essential-trio\"\u003eB-12 Essential Trio, our liquid B12, folinate and B6\u003c\/a\u003e adds more of the B vitamins already here. For medication, bring the bottle to your healthcare practitioner: vitamin K, ashwagandha and biotin are the ones to mention.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eWallace TC et al. Multivitamin\/mineral supplement contribution to micronutrient intakes in the United States, 2007-2010. Journal of the American College of Nutrition. 2014. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24724766\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eTripkovic L et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. The American Journal of Clinical Nutrition. 2012. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22552031\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSchurgers LJ et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17158229\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWankhede S et al. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. Journal of the International Society of Sports Nutrition. 2015. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26609282\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBonilla DA et al. Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis. Journal of Functional Morphology and Kinesiology. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33670194\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eGopukumar K et al. Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34858513\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":44364423921946,"sku":"015-M4002","price":47.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M4002_REV02_Listing_Image_1.png?v=1738258546"},{"product_id":"everyday-liquid-sunshine-2-d3-k2","title":"Everyday Liquid Sunshine 2 D3 + K2 – Bone \u0026 Immune Support | 2 fl oz Drops","description":"\u003cp\u003e\u003cstrong\u003eEveryday Liquid Sunshine 2 is a liquid vitamin D3 and K2 supplement. Each dropper squeeze gives you 5,000 IU (125 mcg) of vitamin D3 as cholecalciferol and 120 mcg of vitamin K2 as all-trans MK-7, dissolved in fractionated coconut oil and sunflower oil with natural orange flavor. One 2 fl oz bottle holds approximately 70 servings. It supports bone and immune system health.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe're built to make vitamin D from sunlight on bare skin. Then life moved indoors, and an Oregon winter of short, cloudy days gives your skin little to work with. Everyday Liquid Sunshine 2 is for adults who know their vitamin D tends to run low (ideally because a blood test told them so), whose practitioner is comfortable with a higher daily dose, and who want D3 and K2 in one morning dropper. Aging isn't optional. Getting old is. Strong bones and a well-supported immune system are two things you'll want working in your 70s and 80s, and the habits behind them are worth starting in your 30s and 40s.†\u003c\/p\u003e\n\u003ch2\u003eWhy people take Everyday Liquid Sunshine 2\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCalcium absorption.\u003c\/strong\u003e Vitamin D3 helps your body absorb the calcium and phosphorus in your food, the raw materials of bone.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBone protein activation.\u003c\/strong\u003e Vitamin K2 activates osteocalcin, one of the main proteins in bone and part of normal bone mineralization.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNormal immune function.\u003c\/strong\u003e Vitamin D supports the immune system, and many immune cells carry vitamin D receptors.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle function.\u003c\/strong\u003e Your muscles need vitamin D to work normally.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSteady vitamin D through darker months.\u003c\/strong\u003e One dropper squeeze a day helps maintain healthy vitamin D levels when sun exposure is limited.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin D3 (cholecalciferol)\u003c\/td\u003e\n\u003ctd\u003e125 mcg (5,000 IU)\u003c\/td\u003e\n\u003ctd\u003e625\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin K2 (all trans MK7)\u003c\/td\u003e\n\u003ctd\u003e120 mcg\u003c\/td\u003e\n\u003ctd\u003e100\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 1 Dropper Squeeze (~0.72 grams). Servings per container: Approx. 70. Other ingredients: Fractionated coconut oil, sunflower oil, and natural orange flavor. The label states: \"NO corn, soy, salt, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\"\u003c\/p\u003e\n\u003ch2\u003eHow Everyday Liquid Sunshine 2 works\u003c\/h2\u003e\n\u003ch3\u003eVitamin D3 (cholecalciferol), 5,000 IU\u003c\/h3\u003e\n\u003cp\u003eVitamin D3 is the same form your skin makes when UVB light hits it. Your liver turns it into 25-hydroxyvitamin D, the number a vitamin D blood test reports, and your kidneys turn that into calcitriol, the active form that tells your gut to absorb calcium and phosphorus.†\u003c\/p\u003e\n\u003cp\u003eWhy D3 and not D2? A 2012 meta-analysis of head-to-head randomized trials found D3 raised blood 25-hydroxyvitamin D more than D2 overall. The gap was clearest with large, infrequent doses and wasn't significant in the daily-dosing trials, so D3 works at least as well as D2, and better overall in the pooled trials (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22552031\/\"\u003eTripkovic 2012\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003eVitamin D also reaches past bone: B cells, T cells and antigen-presenting cells all carry vitamin D receptors, and these immune cells can make active vitamin D themselves, which is part of how vitamin D supports normal immune function (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21527855\/\"\u003eAranow 2011\u003c\/a\u003e).†\u003c\/p\u003e\n\u003cp\u003eWhat the research doesn't show: that more vitamin D on top of adequate levels builds extra bone. A 2014 meta-analysis of 23 trials in 4,082 adults (average age 59) found a small bone density benefit at one hip site, about 0.8%, and none elsewhere. The authors concluded that routine vitamin D for bone density isn't supported in adults without risk factors for low vitamin D (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24119980\/\"\u003eReid 2014\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eVitamin K2 (all-trans MK-7), 120 mcg\u003c\/h3\u003e\n\u003cp\u003eVitamin K is a switch. It activates a family of proteins through a step called carboxylation. In the liver, those proteins handle normal blood clotting. In bone, one of the main ones is osteocalcin, a protein involved in bone mineralization, and it needs vitamin K to switch it on.† Vitamin K2 comes in several forms called menaquinones, and MK-7 is the long-chain form found in fermented foods like natto.\u003c\/p\u003e\n\u003cp\u003eWhy MK-7? In a study in healthy volunteers, vitamin K1 and MK-7 were both absorbed well, but MK-7 stayed in the blood far longer, gave steadier levels, built up to 7- to 8-fold higher levels with prolonged daily use, and activated more osteocalcin (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17158229\/\"\u003eSchurgers 2007\u003c\/a\u003e). The label specifies the all-trans form of MK-7.\u003c\/p\u003e\n\u003cp\u003eIs 120 mcg enough to matter? In a 12-week double-blind trial in 120 Japanese adults aged 20 to 69, 100 mcg of MK-7 a day raised the ratio of activated to inactive osteocalcin compared with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26875489\/\"\u003eInaba 2015\u003c\/a\u003e). One limit: that trial measured a marker of vitamin K activity in bone, not bone density or strength.\u003c\/p\u003e\n\u003ch3\u003eWhy D3 and K2 share a bottle\u003c\/h3\u003e\n\u003cp\u003eVitamin D3 helps your body absorb calcium from food. Vitamin K2 switches on osteocalcin, a bone protein involved in mineralization, the process that lays calcium into bone.† To be straight with you, the studies above tested each vitamin on its own, and long trials of this exact pairing are thin.\u003c\/p\u003e\n\u003ch3\u003eThe oil base\u003c\/h3\u003e\n\u003cp\u003eBoth vitamins are fat-soluble, so they come already dissolved in fractionated coconut oil and sunflower oil. Food fat helps too: in 50 healthy older adults given a single vitamin D3 dose, peak blood D3 was 32% higher with a breakfast containing fat than with a fat-free breakfast (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25441954\/\"\u003eDawson-Hughes 2015\u003c\/a\u003e). The natural orange flavor is there so the dropper tastes like something other than oil.\u003c\/p\u003e\n\u003ch2\u003eHow to take Everyday Liquid Sunshine 2\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDirections on the label:\u003c\/strong\u003e \"Take one serving by mouth in the morning.\"\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA breakfast with some fat in it, like eggs, nuts or avocado toast, is an easy pairing, per the study above.\u003c\/li\u003e\n\u003cli\u003eAt one serving a day, the bottle's approximately 70 servings last about 70 days.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. If you take warfarin or another blood thinner that works against vitamin K, talk to your prescriber first: the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminK-HealthProfessional\/\"\u003eNIH vitamin K fact sheet describes a serious interaction with warfarin\u003c\/a\u003e. The 5,000 IU (125 mcg) of D3 in each serving is above the 4,000 IU (100 mcg) daily upper limit that the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/\"\u003eNIH vitamin D fact sheet lists for everyone 9 and older\u003c\/a\u003e, so use it with your practitioner's guidance and an occasional blood test. Ask a pediatrician before giving it to a child or teen, since 5,000 IU is above the upper limit for every age group. The same NIH vitamin D fact sheet lists other medicines that can interact with vitamin D.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. Here's how we work today.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of Everyday Liquid Sunshine 2 gets its own.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon.\u003c\/strong\u003e We make and test it there. Mt. Angel is a farm town of about 3,500 people in the Willamette Valley, home to our UL-certified cGMP facility. The formulators, makers and testers work under one roof, and the owners work in the building too. We've been owner-run since 2017. And no, we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much vitamin D3 and K2 is in each serving?\u003c\/h3\u003e\n\u003cp\u003eEach dropper squeeze has 5,000 IU (125 mcg) of vitamin D3 as cholecalciferol and 120 mcg of vitamin K2 as all-trans MK-7. That's 625% of the Daily Value for vitamin D and 100% for vitamin K.\u003c\/p\u003e\n\u003ch3\u003eIs 5,000 IU of vitamin D too much?\u003c\/h3\u003e\n\u003cp\u003eIt can be, depending on where your levels start. It's above the 4,000 IU daily upper limit for adults, so it makes the most sense when your practitioner has checked your 25-hydroxyvitamin D and wants you at this dose. For a smaller or adjustable amount, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/everyday-liquid-sunshine-bone-imm\"\u003eEveryday Liquid Sunshine has 1,000 IU of D3 per drop\u003c\/a\u003e, without the K2.\u003c\/p\u003e\n\u003ch3\u003eWhen should I take it, and does it need food?\u003c\/h3\u003e\n\u003cp\u003eTake it in the morning, as the label directs. Pairing it with a breakfast that has some fat in it is a sensible habit, since in one study a breakfast with fat raised peak blood vitamin D3 by 32% compared with a fat-free one.\u003c\/p\u003e\n\u003ch3\u003eHow long before I notice anything?\u003c\/h3\u003e\n\u003cp\u003eProbably not right away. Blood vitamin D climbs gradually over weeks to months, so a follow-up blood test after a few months of daily use tells you more than how you feel.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with Bones + K2 or Calcium Citrate?\u003c\/h3\u003e\n\u003cp\u003eYes to Calcium Citrate: this formula has no calcium, and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/calcium-citrate-60ct\"\u003eCalcium Citrate provides 250 mg of calcium per capsule\u003c\/a\u003e. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/bones-k2-comprehensive-bone-supp\"\u003eBones + K2 already has 25 mcg (1,000 IU) of vitamin D3 and 120 mcg of MK-7 per two-capsule serving\u003c\/a\u003e, so taking both daily adds up to 6,000 IU of D3 and 240 mcg of K2 a day. Check that total with your practitioner before doubling up.\u003c\/p\u003e\n\u003ch3\u003eI take a blood thinner. Can I use this?\u003c\/h3\u003e\n\u003cp\u003eTalk to your prescriber first. Vitamin K directly affects how warfarin-type blood thinners work, and the researchers who compared K1 and MK-7 cautioned that 50 mcg or more of MK-7 a day may interfere with those medicines. Each serving here has 120 mcg.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eTripkovic L et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22552031\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eAranow C. Vitamin D and the immune system. J Investig Med. 2011. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21527855\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eReid IR et al. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24119980\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSchurgers LJ et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17158229\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eInaba N et al. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. J Nutr Sci Vitaminol (Tokyo). 2015. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26875489\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDawson-Hughes B et al. Dietary fat increases vitamin D-3 absorption. J Acad Nutr Diet. 2015. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25441954\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"2 fl oz (1 bottle)","offer_id":44364422250778,"sku":"015-M2113","price":25.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M2113_REV02_Necktag.png?v=1738258716"},{"product_id":"nmn-nr-cellular-wellness-supplement","title":"NMN + NR with Resveratrol and TMG – NAD+ \u0026 Cellular Energy Support | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eNMN + NR with Resveratrol and TMG is a 60-capsule NAD+ formula. Each 2-capsule serving provides 500 mg β-nicotinamide mononucleotide (NMN), 200 mg nicotinamide riboside (NR), 250 mg resveratrol, 50 mg TMG, 50 mg Bioperine® black pepper extract and 10 mg zinc (as bisglycinate chelate), to support cellular energy production and healthy NAD+ levels.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNMN and NR are two building blocks your body uses to make NAD+, which every cell needs for energy and upkeep. This formula puts both in one bottle. It's built for people in their late 30s and 40s who are already working on energy and cellular health, and for anyone over 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take NMN + NR\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealthy NAD+ levels.\u003c\/strong\u003e NMN and NR are both NAD+ precursors, and each raised blood NAD+ in placebo-controlled trials in healthy adults.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular energy.\u003c\/strong\u003e Your mitochondria use NAD+ to turn food into ATP, the energy your cells run on.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNormal DNA repair.\u003c\/strong\u003e PARPs, enzymes involved in routine DNA repair, need NAD+ to work, and so do sirtuins.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant support.\u003c\/strong\u003e Resveratrol is a plant polyphenol studied for its role in the body's normal defenses against everyday oxidative stress.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMethylation and enzyme support.\u003c\/strong\u003e TMG donates methyl groups for normal methylation, and zinc helps hundreds of enzymes work.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eβ-Nicotinamide Mononucleotide\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root)\u003c\/td\u003e\n\u003ctd\u003e250 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide riboside\u003c\/td\u003e\n\u003ctd\u003e200 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTrimethylglycine (TMG) (Betaine anhydrous)\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit)\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (as bisglycinate chelate)\u003c\/td\u003e\n\u003ctd\u003e10 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*Daily Value not established, as printed on the label. Serving size: 2 capsules. Servings per container: 30. Other ingredients: Vegetarian Capsule (Hypromellose and water), organic brown rice and magnesium stearate. The label states: \"NO soy, salt, yeast, gluten, milk \u0026amp; egg products, sugar, starch, or preservatives.\" Bioperine® is a registered trademark of Sabinsa Corporation.\u003c\/p\u003e\n\u003ch2\u003eHow NMN + NR works\u003c\/h2\u003e\n\u003ch3\u003eNMN (β-nicotinamide mononucleotide), 500 mg\u003c\/h3\u003e\n\u003cp\u003eNMN is one step away from NAD+ (nicotinamide adenine dinucleotide), a coenzyme in every cell. Mitochondria use NAD+ to make ATP, and sirtuins and PARPs use it up as they work, so cells keep rebuilding it, and NMN is one of the pieces.† Edamame, broccoli and meat contain it, but only about 1 mg per 100 grams, as the authors of \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35927255\/\"\u003ea 12-week NMN trial in healthy older men\u003c\/a\u003e note.\u003c\/p\u003e\n\u003cp\u003eIn that trial, 42 healthy men aged 65 and older were randomized to 250 mg of NMN or placebo daily, though a supplier mix-up left 12-week results for only 20 of them. NMN raised NAD+ in whole blood and was well tolerated. Gait speed and left-hand grip showed nominal gains the authors say larger studies must confirm, and muscle mass didn't change. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ea 60-day dose-comparison trial in 80 healthy middle-aged adults\u003c\/a\u003e, 300, 600 or 900 mg a day raised blood NAD+ in every group, most at 600 and 900 mg, and six-minute walk distance rose more than with placebo. Several authors work for chemical and biotech companies, so it's worth seeing repeated. On safety, in \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36002548\/\"\u003ea four-week placebo-controlled safety trial in 31 healthy adults\u003c\/a\u003e funded by an NMN maker, 1,250 mg a day produced no changes beyond normal variation.\u003c\/p\u003e\n\u003cp\u003eWhat it doesn't show: these trials ran weeks, not years, higher blood NAD+ isn't proof of a change you'll feel, and we haven't found a trial of this exact combination. Our \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/nad-longevity-complete-guide\"\u003eguide to how NAD+ works and why levels change with age\u003c\/a\u003e goes deeper.\u003c\/p\u003e\n\u003ch3\u003eNR (nicotinamide riboside), 200 mg\u003c\/h3\u003e\n\u003cp\u003eNR is a form of vitamin B3. Inside cells, an enzyme called NRK turns NR into NMN, which then becomes NAD+. NMN can also be converted to NR outside cells and rebuilt inside. So the two are neighbors on the same road, and taking both offers two entry points.†\u003c\/p\u003e\n\u003cp\u003eIn \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ea crossover trial in 30 healthy adults aged 55 to 79\u003c\/a\u003e, 500 mg of NR twice a day for six weeks was well tolerated and raised NAD+ in blood cells by about 60% versus placebo. The 200 mg here is a supporting dose, not a copy of that trial.\u003c\/p\u003e\n\u003ch3\u003eResveratrol, 250 mg from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e root\u003c\/h3\u003e\n\u003cp\u003eResveratrol is a polyphenol best known from grape skins; ours comes from Japanese knotweed (\u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) root. Lab research studies how it interacts with sirtuins, the NAD+-using enzymes above, which is why it's often paired with NAD+ precursors. We haven't found human trials of that pairing, and little of a resveratrol dose reaches the blood intact (low bioavailability).\u003c\/p\u003e\n\u003cp\u003eIn \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24804871\/\"\u003ea small single-dose study of resveratrol with and without piperine\u003c\/a\u003e, 23 adults took placebo, 250 mg of trans-resveratrol, or the same with 20 mg of piperine, on separate days. Thinking-task scores and mood didn't change, though the pair increased blood flow in the front of the brain during tasks. In a separate group of six, piperine didn't raise blood resveratrol. Interesting, early, and one study.\u003c\/p\u003e\n\u003ch3\u003eTMG (trimethylglycine), 50 mg\u003c\/h3\u003e\n\u003cp\u003eTMG, also called betaine, carries three methyl groups and hands them off in a process called methylation.† Why it's here: the body clears some of the nicotinamide left over from NAD+ use by attaching methyl groups to it, and TMG is a methyl donor. That's a sensible rationale, not a tested result. In \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14652361\/\"\u003ea six-week betaine trial in healthy men and women\u003c\/a\u003e, 1.5 to 6 grams a day lowered fasting homocysteine 12 to 20% versus placebo. A serving here has 50 mg, so we don't claim that effect.\u003c\/p\u003e\n\u003ch3\u003eBioperine® (black pepper fruit extract), 50 mg\u003c\/h3\u003e\n\u003cp\u003eBioperine® is a black pepper extract rich in piperine, which can change how the body absorbs and breaks down some compounds. The resveratrol study above found no rise in blood levels, so we don't promise one.\u003c\/p\u003e\n\u003ch3\u003eZinc (as bisglycinate chelate), 10 mg\u003c\/h3\u003e\n\u003cp\u003eZinc is needed for the activity of hundreds of enzymes and plays a role in making protein and DNA and in normal cell division, per the \u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Zinc-HealthProfessional\/\"\u003eNIH Office of Dietary Supplements zinc fact sheet\u003c\/a\u003e.† Bisglycinate chelate means the zinc is bound to the amino acid glycine. The adult RDA is 8 mg for women and 11 mg for men, and the adult upper limit from all sources is 40 mg a day.\u003c\/p\u003e\n\u003ch2\u003eHow to take NMN + NR\u003c\/h2\u003e\n\u003cp\u003eDirections: Take 2 capsules daily, as a dietary supplement. That one 2-capsule serving a day makes each 60-capsule bottle a 30-day supply.\u003c\/p\u003e\n\u003cp\u003eIf you take other zinc, as in a multivitamin, add up your daily total and keep it under the 40 mg adult upper limit.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are rejected.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003eSee the certificates of analysis for this product\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and we make and test this formula there in our UL-certified cGMP facility. Formulators, makers and testers work under one roof, and the owners work in the building too (owner-run since 2017). We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much NMN and NR is in each serving?\u003c\/h3\u003e\n\u003cp\u003eEach 2-capsule serving has 500 mg of NMN and 200 mg of NR, plus 250 mg of resveratrol, 50 mg of TMG, 50 mg of Bioperine® and 10 mg of zinc. Trials in healthy adults have used up to 900 mg of NMN a day for 60 days and 1,250 mg a day for four weeks without safety problems, though longer-term data at these amounts are limited.\u003c\/p\u003e\n\u003ch3\u003eWhy combine NMN and NR?\u003c\/h3\u003e\n\u003cp\u003eIt gives your body two entry points into the same NAD+ pathway.† We haven't found a trial comparing the pair with an equal amount of either one alone, so it's a reasonable design, not a proven advantage. Here's \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/nmn-vs-nicotinamide-riboside\"\u003ehow NMN and NR differ\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow long before I notice anything?\u003c\/h3\u003e\n\u003cp\u003eNo one can promise a timeline. Blood NAD+ was already higher at the 30-day check in one trial, but NAD+ isn't something you feel like coffee, and most trials above ran 6 to 12 weeks.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with Urolithin A?\u003c\/h3\u003e\n\u003cp\u003eYes. Our \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack\u003c\/a\u003e pairs one bottle each of NMN + NR and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A 500 mg\u003c\/a\u003e. Urolithin A is studied for how cells recycle worn-out mitochondria, while NMN and NR supply NAD+ building blocks.†\u003c\/p\u003e\n\u003ch3\u003eIs it safe with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner before combining it with medication. Piperine, the main compound in Bioperine®, can change how the body absorbs and processes some compounds, and NAD+ precursors haven't been studied alongside most prescriptions.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/nmn-nicotinamide-mononucleotide\"\u003eWhat the human research says about NMN, dose by dose\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/urolithin-a-vs-nmn\"\u003eHow urolithin A and NMN work differently, and which to start with\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eIgarashi M et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35927255\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eFukamizu Y et al. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Sci Rep. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36002548\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWightman EL et al. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr. 2014. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24804871\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eOlthof MR et al. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14652361\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":50096171581722,"sku":"015-M1026","price":59.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M1026_REV01_New_Item.png?v=1738258899"},{"product_id":"cortiresponse-stress-mood-support","title":"CortiResponse – Daily Stress, Mood \u0026 Mental Clarity Support | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eCortiResponse is a 60-capsule formula for daily stress, mood and mental clarity support.† Each 2-capsule serving combines 100 mg of L-theanine, 100 mg of ashwagandha root, 180 mg of holy basil 10:1 extract, 100 mg of passionflower 4:1 extract and 300 mg of magnolia bark 4:1 extract with green tea, cocoa and 120 mcg of chromium. It's made to support a healthy response to occasional stress.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStress doesn't book an appointment. In your 30s and 40s it's deadlines, kids, aging parents and a phone that won't stop buzzing, and the habits you build now carry into the decades ahead. CortiResponse is one simple daily step for staying steady and clear-headed, alongside sleep, food and movement.† Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003ch2\u003eWhy people take CortiResponse\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eTo support a healthy cortisol response to occasional, everyday stress, with ashwagandha, holy basil and magnolia bark.†\u003c\/li\u003e\n\u003cli\u003eTo support calm, relaxed alertness, with 100 mg of L-theanine.†\u003c\/li\u003e\n\u003cli\u003eTo support a positive mood and ease occasional tension, with passionflower and magnolia bark.†\u003c\/li\u003e\n\u003cli\u003eTo support mental clarity and focus on demanding days.†\u003c\/li\u003e\n\u003cli\u003eTo support normal carbohydrate metabolism, with 120 mcg of chromium.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChromium (chromium polynicotinate, GTF)\u003c\/td\u003e\n\u003ctd\u003e120 mcg\u003c\/td\u003e\n\u003ctd\u003e342%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCocoa Seed Extract (\u003cem\u003eTheobroma cacao\u003c\/em\u003e) (standardized to 6% theobromine)\u003c\/td\u003e\n\u003ctd\u003e300 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnolia Bark 4:1 Extract (\u003cem\u003eMagnolia officinalis\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e300 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGreen Tea Leaf Extract (\u003cem\u003eCamilla sinensis\u003c\/em\u003e) (standardized to 50% polyphenols and 35% catechins)\u003c\/td\u003e\n\u003ctd\u003e200 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHoly Basil Herb 10:1 Extract (\u003cem\u003eOcimum sanctum\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e180 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAshwagandha Root (\u003cem\u003eWithania somnifera\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePassionflower Herb (\u003cem\u003ePassiflora incarnata\u003c\/em\u003e) 4:1 Extract\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eL-Theanine\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBanaba Leaf Standardized Extract (\u003cem\u003eLagerstroemia speciosa\u003c\/em\u003e) (standardized to 1% corosolic acid)\u003c\/td\u003e\n\u003ctd\u003e10 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e* Daily Value not established. Serving size: 2 vegetarian capsules. Servings per container: 30. Each bottle holds 60 capsules. Other ingredients: Cellulose (from capsule shell), cellulose, vegetable stearate, and silicon dioxide. The bottle's side panel carries Gluten-Free, Dairy-Free, Soy-Free and Made in the USA icons.\u003c\/p\u003e\n\u003ch2\u003eHow CortiResponse works\u003c\/h2\u003e\n\u003cp\u003eStress tells your adrenal glands to release cortisol through what researchers call the HPA (hypothalamic-pituitary-adrenal) axis. The goal is a response that rises when you need it and settles when you don't, and several ingredients below were studied for that.† Many studies used branded extracts, often at higher amounts than one serving.\u003c\/p\u003e\n\u003ch3\u003eL-theanine, 100 mg\u003c\/h3\u003e\n\u003cp\u003eL-theanine is an amino acid from tea leaves. In a crossover trial in healthy, moderately stressed adults, a single 200 mg dose produced a larger rise in alpha brain waves (the pattern linked with relaxed alertness) than placebo three hours later, and a larger drop in salivary cortisol at one hour (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34562208\/\"\u003ea single-dose L-theanine trial during a mental stress test\u003c\/a\u003e). In a four-week crossover trial, 30 healthy adults (average age 48) took 200 mg a day in one period and a placebo in another. Stress-symptom and sleep-quality scores improved during the L-theanine weeks (some sleep scores beat placebo outright), as did verbal fluency and executive function (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31623400\/\"\u003ea four-week L-theanine trial in healthy adults\u003c\/a\u003e). Both studies were small and used twice the amount in one serving.†\u003c\/p\u003e\n\u003ch3\u003eAshwagandha root, 100 mg\u003c\/h3\u003e\n\u003cp\u003eAshwagandha (\u003cem\u003eWithania somnifera\u003c\/em\u003e) is a root from Ayurvedic tradition and one of the most researched herbs scientists call adaptogens. In a 60-day trial, 60 healthy adults with high self-reported stress took 240 mg of a standardized extract or a placebo daily. The ashwagandha group had a larger drop in morning cortisol, with no side effects reported (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ea 60-day ashwagandha trial in stressed, healthy adults\u003c\/a\u003e). The candid part: CortiResponse has 100 mg of ashwagandha root, not a concentrated extract, so it plays a supporting role.†\u003c\/p\u003e\n\u003ch3\u003eHoly basil 10:1 extract, 180 mg\u003c\/h3\u003e\n\u003cp\u003eHoly basil, or tulsi (\u003cem\u003eOcimum sanctum\u003c\/em\u003e, also called \u003cem\u003eOcimum tenuiflorum\u003c\/em\u003e), is a cousin of kitchen basil. A 10:1 extract is concentrated from about 10 parts herb to 1 part extract. In an 8-week trial, 100 stressed adults aged 18 to 65 took 125 mg of a standardized holy basil extract twice a day or a placebo. The holy basil group saw bigger improvements in perceived stress and sleep-quality scores, lower hair cortisol at week 8, and lower salivary cortisol after a lab stress test (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36185698\/\"\u003ean 8-week holy basil trial in stressed adults\u003c\/a\u003e). That was a different extract than ours, so read it as evidence for the herb, not this capsule.†\u003c\/p\u003e\n\u003ch3\u003eMagnolia bark 4:1 extract, 300 mg\u003c\/h3\u003e\n\u003cp\u003eMagnolia bark (\u003cem\u003eMagnolia officinalis\u003c\/em\u003e) is a staple of traditional Chinese herbal practice. Most human research pairs it with a second bark, phellodendron. In a 4-week trial, 56 moderately stressed adults took that combination or a placebo. The combination group's salivary cortisol exposure was 18% lower than placebo, and their mood-state scores, including tension and fatigue, were better (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23924268\/\"\u003ea 4-week magnolia and phellodendron trial\u003c\/a\u003e). CortiResponse has no phellodendron, so that study speaks to the pairing, not magnolia alone.†\u003c\/p\u003e\n\u003ch3\u003ePassionflower 4:1 extract, 100 mg\u003c\/h3\u003e\n\u003cp\u003ePassionflower (\u003cem\u003ePassiflora incarnata\u003c\/em\u003e) is a climbing vine with a long folk history as a calming herb. The 100 mg of 4:1 extract comes from about 400 mg of the dried herb. Most human passionflower trials took place in medical settings, not everyday stress, so we don't cite them here.†\u003c\/p\u003e\n\u003ch3\u003eGreen tea leaf and cocoa seed extracts\u003c\/h3\u003e\n\u003cp\u003eThe green tea leaf extract (200 mg) is standardized to 50% polyphenols and 35% catechins, about 100 mg of polyphenols and 70 mg of catechins per serving. Catechins such as EGCG are green tea's best-known antioxidants. The cocoa seed extract (300 mg) is standardized to 6% theobromine, about 18 mg per serving. Theobromine is cocoa's gentler cousin of caffeine.†\u003c\/p\u003e\n\u003ch3\u003eChromium and banaba leaf\u003c\/h3\u003e\n\u003cp\u003eChromium is a trace mineral that might help insulin do its job, and it may play a role in carbohydrate, fat and protein metabolism (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Chromium-HealthProfessional\/\"\u003eNIH fact sheet on chromium\u003c\/a\u003e). Ours is chromium polynicotinate (chromium bound to niacin), sometimes labeled GTF. No upper limit has been set for chromium. Banaba leaf extract adds 10 mg. Most human banaba research involves people whose blood sugar is outside the normal range, so we don't cite it here.†\u003c\/p\u003e\n\u003ch2\u003eHow to take CortiResponse\u003c\/h2\u003e\n\u003cp\u003eThe label says: \"Take one to two capsules, 30 minutes before a meal, as a dietary supplement.\" The amounts in the table are for a 2-capsule serving.\u003c\/p\u003e\n\u003cp\u003eThe label warns: \"Not recommended while pregnant or lactating unless directed by a health care practitioner.\" Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. Ashwagandha has been well tolerated in trials lasting up to about three months, and its long-term safety isn't known (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Ashwagandha-HealthProfessional\/\"\u003eNIH fact sheet on ashwagandha\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of CortiResponse gets its own.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley. Our UL-certified cGMP facility keeps the formulators, the makers and the testers under one roof, and the owners (it's been owner-run since 2017) work in the building. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow many CortiResponse capsules should I take?\u003c\/h3\u003e\n\u003cp\u003eOne to two capsules, 30 minutes before a meal, per the label. The Supplement Facts amounts are for 2 capsules.\u003c\/p\u003e\n\u003ch3\u003eDoes CortiResponse contain caffeine?\u003c\/h3\u003e\n\u003cp\u003eThe label doesn't list caffeine. It does contain green tea leaf extract, which can carry some naturally occurring caffeine, and cocoa seed extract, which supplies about 18 mg of theobromine per serving. Sensitive to stimulants? Start with one capsule.\u003c\/p\u003e\n\u003ch3\u003eWill CortiResponse make me drowsy?\u003c\/h3\u003e\n\u003cp\u003eIt isn't made as a sleep formula: there's no melatonin on the label, and the L-theanine research focuses on calm alertness. The NIH lists mild drowsiness as a possible ashwagandha side effect, so notice how you feel at first.\u003c\/p\u003e\n\u003ch3\u003eHow long does it take to notice CortiResponse?\u003c\/h3\u003e\n\u003cp\u003eIt depends on the ingredient. The L-theanine trial measured changes within hours of one dose, while the ashwagandha and holy basil trials ran 60 days and 8 weeks.\u003c\/p\u003e\n\u003ch3\u003eCan I take CortiResponse with your other products?\u003c\/h3\u003e\n\u003cp\u003eYes, but check for shared ingredients first. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/relaxation-supplement-passion-fl\"\u003eRelaxing Passion Flower lozenges\u003c\/a\u003e (50 mg of passionflower 4:1 extract each) and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/natural-sleep-aid-herbal-support\"\u003eSleepy Sleep\u003c\/a\u003e both contain passionflower. \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/adrenal-support-60-vegetarian\"\u003eAdrenal Support\u003c\/a\u003e also has ashwagandha, \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/good-magnesium-chelate-amino-acids\"\u003eGood Magnesium\u003c\/a\u003e lists holy basil in its other ingredients, and \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/brain-advantage\"\u003eBrain Advantage\u003c\/a\u003e has 30 mg of L-theanine. If you stack, run the combination by your practitioner.\u003c\/p\u003e\n\u003ch3\u003eCan I take CortiResponse with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first. Per the NIH fact sheets, ashwagandha might interact with thyroid hormone, blood sugar, blood pressure, immune-suppressing and sedative medications, and chromium might add to the effect of blood sugar medications or reduce levothyroxine absorption.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/blog\/new\/single-bottle-solution-what-is-it-and-why-do-we-put-it-on-our-premium-bottles\"\u003eWhat \"Single Bottle Solution\" on our labels means\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eEvans M et al. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population. Neurology and Therapy. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34562208\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHidese S et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31623400\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLopresti AL et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31517876\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLopresti AL et al. A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer™) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36185698\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eTalbott SM et al. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition. 2013. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23924268\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"60","offer_id":50951720304922,"sku":"015-A6001","price":33.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/A6001_REV00_NewItemBadge.png?v=1755025348"},{"product_id":"brain-advantage","title":"Brain Advantage – Brain Energy, Focus \u0026 Recall Support | 60 Vegetarian Capsules","description":"\u003cp\u003e\u003cstrong\u003eBrain Advantage is a two-capsule daily nootropic with 250 mg of Cognizin® citicoline, 320 mg of Synapsa™ bacopa extract standardized to 55% bacosides, and 500 mg of lion's mane extract, plus ginkgo, L-theanine, methylfolate, niacinamide, vitamin C, magnesium and zinc. Each bottle holds 60 vegetarian capsules, a 30-day supply. It supports brain energy, mental focus and recall.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBrain Advantage is for people who would like their memory to keep up with their calendar. Maybe you're 42 and juggling a team and a household. Maybe you're 60 and have big plans for your 80s. Either way, the time to look after your brain is before you're worried about it, which for most people means starting in your 30s and 40s. Aging isn't optional. Getting old is.\u003c\/p\u003e\n\u003cp\u003eThere's no caffeine in it and nothing designed to give you a buzz. Citicoline and bacopa, the two headline ingredients, both have placebo-controlled research in healthy adults, and both are here as named, branded ingredients with every amount printed. No proprietary blend, no guessing.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Brain Advantage\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBrain energy.\u003c\/strong\u003e Citicoline supplies choline and cytidine, raw materials brain cells use to build their membranes, and it is studied for its role in brain energy metabolism.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFocus and attention.\u003c\/strong\u003e Brain Advantage supports mental focus, and bacopa supports attention and processing speed with consistent daily use.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMemory and recall.\u003c\/strong\u003e Bacopa supports learning and the retention of newly learned information with steady daily use.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEveryday nutrient support.\u003c\/strong\u003e Folate as L-5-methyltetrahydrofolate supports normal methylation, and niacinamide (vitamin B3) supports normal energy metabolism.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eVitamin C (from Magnesium and Zinc Ascorbate)\u003c\/td\u003e\n\u003ctd\u003e100 mg\u003c\/td\u003e\n\u003ctd\u003e111%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNiacinamide\u003c\/td\u003e\n\u003ctd\u003e122 mg\u003c\/td\u003e\n\u003ctd\u003e766%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFolate (from L-5-Methyltetrahydrofolate, LMTHF)\u003c\/td\u003e\n\u003ctd\u003e400 mcg DFE\u003c\/td\u003e\n\u003ctd\u003e100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium (from magnesium ascorbate)\u003c\/td\u003e\n\u003ctd\u003e22 mg\u003c\/td\u003e\n\u003ctd\u003e5%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (from zinc ascorbate)\u003c\/td\u003e\n\u003ctd\u003e11 mg\u003c\/td\u003e\n\u003ctd\u003e100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLion's Mane Extract (from \u003cem\u003eHercicium erinaceus\u003c\/em\u003e mushroom)\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eBacopa monnieri\u003c\/em\u003e whole plant extract (from Synapsa™, standardized to 55% Bacosides)\u003c\/td\u003e\n\u003ctd\u003e320 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCiticoline (from Cognizin®)\u003c\/td\u003e\n\u003ctd\u003e250 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eGinkgo biloba\u003c\/em\u003e Leaf Extract (contains 24% ginkgoflavonglycosides and 6% terpene lactones)\u003c\/td\u003e\n\u003ctd\u003e60 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eL-Theanine\u003c\/td\u003e\n\u003ctd\u003e30 mg\u003c\/td\u003e\n\u003ctd\u003eNot established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eServing size: 2 Vegetarian Capsules. Servings per container: 30. Other ingredients: Vegetable Cellulose (from capsule shell), Organic Rice Extract, Silica, and Organic Rice Concentrate. The front label carries gluten-free, dairy-free and soy-free icons.\u003c\/p\u003e\n\u003ch2\u003eHow Brain Advantage works\u003c\/h2\u003e\n\u003ch3\u003eCognizin® citicoline (250 mg)\u003c\/h3\u003e\n\u003cp\u003eCiticoline, also called CDP-choline, is a compound your body already makes from two parts, choline and cytidine. Brain cells use them to build phosphatidylcholine, a main ingredient in cell membranes, and choline is also the raw material for acetylcholine, a messenger that attention and memory circuits rely on.† Cognizin, from Kyowa Hakko Bio, is the citicoline used in both studies below.\u003c\/p\u003e\n\u003cp\u003eIn a small 6-week study with no placebo group, 16 healthy adults (average age 47) took 500 mg or 2,000 mg of Cognizin a day, and brain scans showed higher energy reserves in the frontal lobe, including a 14% rise in a measure that mostly reflects ATP, the molecule cells spend as energy (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18816480\/\"\u003eSilveri et al., 2008\u003c\/a\u003e). In a 12-week placebo-controlled trial of 100 healthy adults aged 50 to 85 with mild, age-related memory changes, the 49 who took 500 mg a day improved more than the placebo group on episodic memory (remembering pairs of items) and an overall memory score (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33978188\/\"\u003eNakazaki et al., 2021\u003c\/a\u003e). Fair warning: those were secondary outcomes, scientists from Cognizin's maker were among the authors, and 500 mg is twice the amount in a serving here.\u003c\/p\u003e\n\u003ch3\u003eSynapsa™ bacopa (320 mg)\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eBacopa monnieri\u003c\/em\u003e is a creeping wetland herb with a long history in Ayurvedic tradition. Its active compounds, the bacosides, vary a lot from one extract to another, which is why this label states the standardization: 55% bacosides. Synapsa is the U.S. name for the extract sold in Australia as KeenMind.\u003c\/p\u003e\n\u003cp\u003eBacopa is a slow worker. In a 12-week placebo-controlled trial in healthy adults, 300 mg a day of KeenMind improved speed of visual information processing, learning rate and memory consolidation (how well newly learned information sticks), with the largest effects at week 12 rather than week 5 (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11498727\/\"\u003eStough et al., 2001\u003c\/a\u003e). A meta-analysis of nine placebo-controlled trials with 518 participants, testing standardized bacopa extracts for 12 weeks or more, found faster times on two attention and reaction-time tests (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24252493\/\"\u003eKongkeaw et al., 2014\u003c\/a\u003e). The differences were measured in milliseconds: statistically clear, but small.\u003c\/p\u003e\n\u003ch3\u003eLion's mane mushroom extract (500 mg)\u003c\/h3\u003e\n\u003cp\u003eLion's mane (\u003cem\u003eHericium erinaceus\u003c\/em\u003e) is an edible mushroom that looks like a shaggy white pom-pom, and its human research is early. In a pilot trial of 41 healthy adults aged 18 to 45, a single 1.8 g dose made people faster on one attention test an hour later, 28 days of use brought a trend toward lower self-reported stress that just missed statistical significance, and several other measures didn't change (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38004235\/\"\u003eDocherty et al., 2023\u003c\/a\u003e). That's more than three times the 500 mg here, so lion's mane is a supporting ingredient, not the reason to buy.\u003c\/p\u003e\n\u003ch3\u003eGinkgo biloba (60 mg) and L-theanine (30 mg)\u003c\/h3\u003e\n\u003cp\u003eThe ginkgo leaf extract is standardized to 24% ginkgoflavonglycosides and 6% terpene lactones, as the label states. L-theanine is an amino acid found in tea leaves. Both are here in supporting amounts, and we don't ask them to carry the formula.\u003c\/p\u003e\n\u003ch3\u003eThe vitamins and minerals\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eFolate (400 mcg DFE)\u003c\/strong\u003e comes as L-5-methyltetrahydrofolate, the form your body already uses, so there's no conversion step from folic acid. It supports normal methylation, a basic chemical process your cells run every day.† \u003cstrong\u003eNiacinamide (122 mg)\u003c\/strong\u003e is a form of vitamin B3 that your cells use to make NAD+, a coenzyme involved in turning food into energy,† and it doesn't cause the skin flushing that nicotinic acid can (\u003ca href=\"https:\/\/ods.od.nih.gov\/factsheets\/Niacin-HealthProfessional\/\"\u003eNIH niacin fact sheet\u003c\/a\u003e). \u003cstrong\u003eVitamin C (100 mg), magnesium (22 mg) and zinc (11 mg)\u003c\/strong\u003e arrive together as magnesium and zinc ascorbate, so the minerals come bound to the vitamin C. Vitamin C supports the body's normal antioxidant defenses, and many of your enzymes depend on zinc.†\u003c\/p\u003e\n\u003ch2\u003eHow to take Brain Advantage\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDirections on the label:\u003c\/strong\u003e \"Take two capsules daily, as a dietary supplement.\"\u003c\/p\u003e\n\u003cp\u003eTwo capsules is one serving, so a bottle lasts 30 days. Give it time: the 12-week bacopa and citicoline trials above measured results after three months of daily use.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. That goes double if you take a blood thinner or thyroid medication, since Brain Advantage contains ginkgo and bacopa.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cp\u003eWe've been making supplements in Oregon since 1974. Fifty-two years in, we know a nice adjective isn't proof. Here's what is.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the citicoline and bacopa included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e Every lot of Brain Advantage gets its own.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon, with globally sourced ingredients.\u003c\/strong\u003e Brain Advantage is formulated, made and tested in our UL-certified cGMP facility in Mt. Angel, a farm town of about 3,500 people in the Willamette Valley. Our formulators, makers and testers work under one roof, and the owners work in the building too. Owner-run since 2017, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow long does Brain Advantage take to work?\u003c\/h3\u003e\n\u003cp\u003ePlan on about 12 weeks of daily use before you judge it. In a placebo-controlled trial, bacopa's effects were largest at 12 weeks, and the citicoline memory trial also ran 12 weeks. Brain Advantage isn't a stimulant, so don't expect a jolt on day one.\u003c\/p\u003e\n\u003ch3\u003eDoes Brain Advantage have caffeine?\u003c\/h3\u003e\n\u003cp\u003eNo. There's no caffeine or other stimulant on the Supplement Facts panel, so you can keep your usual coffee or tea.\u003c\/p\u003e\n\u003ch3\u003eCan I take Brain Advantage with a multivitamin or CortiResponse?\u003c\/h3\u003e\n\u003cp\u003eUsually, yes, but add up the overlaps. Brain Advantage already gives you 122 mg of niacinamide, 400 mcg DFE of folate and 11 mg of zinc, so if you also take a multivitamin like our \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mens-multi-vitamin-60-capsules\"\u003eMen's Multi\u003c\/a\u003e or \u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/womens-multi-cap-60ct\"\u003eWomen's Multi\u003c\/a\u003e, or a B-complex, check the totals on both labels. CortiResponse also contains L-theanine. If you take medication or aren't sure about a combination, ask your practitioner.\u003c\/p\u003e\n\u003ch3\u003eWhat makes Cognizin and Synapsa different from generic citicoline and bacopa?\u003c\/h3\u003e\n\u003cp\u003eThey're named, standardized ingredients you can trace to specific research: Cognizin is the citicoline in both citicoline studies above, and Synapsa is the U.S. name for the bacopa extract in the 12-week trial. A label that just says \"bacopa extract\" doesn't tell you which extract you're getting.\u003c\/p\u003e\n\u003ch3\u003eIs Brain Advantage safe to take with medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first, and bring the bottle. Ginkgo and bacopa are the two ingredients worth naming, especially with a blood thinner or thyroid medication.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/bacopa-monnieri\"\u003eWhat the bacopa research does and doesn't show, trial by trial\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness, our formula for cellular energy and healthy NAD+ levels\u003c\/a\u003e†\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/cortiresponse-stress-mood-support\"\u003eCortiResponse, our ashwagandha and L-theanine formula for everyday stress\u003c\/a\u003e†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSilveri MM et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR in Biomedicine. 2008. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18816480\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eNakazaki E et al. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. The Journal of Nutrition. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33978188\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eStough C et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology. 2001. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11498727\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKongkeaw C et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of Ethnopharmacology. 2014. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24252493\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDocherty S et al. The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. 2023. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38004235\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":50978625356058,"sku":"015-M1005","price":61.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M1005_REV01_New_Item_Badge.png?v=1755624483"},{"product_id":"mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules","title":"Urolithin A 500 mg – Mitochondrial Renewal \u0026 Cellular Energy | 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eMt. Angel Vitamins Urolithin A gives you 500 mg of urolithin A in a single capsule, with 60 capsules per bottle: a 60-day supply at the label's one capsule a day. Urolithin A is a compound some people's gut bacteria make from plant tannins in pomegranates, walnuts and berries. It supports mitophagy, the way your cells recycle worn-out mitochondria, for cellular energy, muscle strength and healthy aging.†\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAging isn't optional. Getting old is. Urolithin A is for people who want their muscles and their energy to keep up for the long haul: people in their late 30s and 40s already planning how they want to feel at 75, and people over 50 who intend to keep going strong. The strength and endurance trials enrolled adults from 40 to 90, so that's where the evidence lives.\u003c\/p\u003e\n\u003ch2\u003eWhy people take Urolithin A\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial renewal.\u003c\/strong\u003e Supports mitophagy, the routine where cells tag worn-out mitochondria, take them apart and recycle the pieces.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular energy.\u003c\/strong\u003e Supports healthy mitochondrial function and cellular energy production.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle strength.\u003c\/strong\u003e In a 4-month trial in sedentary middle-aged adults, 500 mg a day supported leg muscle strength compared with placebo.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial health markers.\u003c\/strong\u003e In healthy older adults, 4 weeks at 500 mg a day shifted blood and muscle markers of mitochondrial health.†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealthy aging.\u003c\/strong\u003e Supports the mitochondrial upkeep that tends to slow down as we get older.†\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat's in each serving\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount per serving\u003c\/th\u003e\n\u003cth\u003e% Daily Value\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eUrolithin A\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003ctd\u003e*\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*Daily Value not established. Serving size: 1 Capsule. Servings per container: 60. Other ingredients: Cellulose (from capsule shell), brown rice protein, and vegetable stearates. The label states: \"NO soy, salt, yeast, gluten, wheat, milk \u0026amp; egg products, sugar, starch, or preservatives.\" One active ingredient, no proprietary blend.\u003c\/p\u003e\n\u003ch2\u003eHow Urolithin A works\u003c\/h2\u003e\n\u003ch3\u003eWhere urolithin A comes from\u003c\/h3\u003e\n\u003cp\u003eYou don't actually eat urolithin A. Pomegranates, walnuts and some berries contain ellagitannins, and certain gut bacteria convert those into urolithin A, if you carry them. In a study of 100 healthy adults, just 12% had detectable urolithin A in their blood at the start, and about 40% converted a meaningful amount after a glass of pomegranate juice. A 500 mg serving of urolithin A delivered more than six times the exposure of the juice (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34117375\/\"\u003eSingh et al., 2021\u003c\/a\u003e). Taking the finished compound means the same amount every day, no matter who lives in your gut.\u003c\/p\u003e\n\u003ch3\u003eMitophagy, in plain English\u003c\/h3\u003e\n\u003cp\u003eMitochondria are the parts of your cells that turn food and oxygen into usable energy. They wear out. A worn mitochondrion makes less energy and more junk, so healthy cells tag the damaged ones, break them down and recycle the parts so replacements can be built. That cleanup is called mitophagy, and it tends to slow down as we get older, right about when you'd want it running well. Urolithin A supports that recycling process.†\u003c\/p\u003e\n\u003cp\u003eThe human evidence for the mechanism comes from muscle, because muscle is packed with mitochondria and easy to sample. In the first human study, 4 weeks at 500 mg or 1,000 mg a day shifted blood and muscle markers of mitochondrial health in healthy, sedentary older adults (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32694802\/\"\u003eAndreux et al., 2019\u003c\/a\u003e). In a 4-month trial, the 500 mg daily dose raised the active form of Parkin, one of the proteins that marks a mitochondrion for recycling, in muscle samples (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). It doesn't add energy from the outside; it supports maintenance your cells already do.†\u003c\/p\u003e\n\u003ch3\u003eWhat the human trials found\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eStrength in middle age.\u003c\/strong\u003e In a 4-month randomized, placebo-controlled trial, 88 sedentary adults aged 40 to 64 took 500 mg, 1,000 mg or placebo daily. Average hamstring strength improved about 12% in the 500 mg group and 9.8% in the 1,000 mg group, both significant compared with placebo, while the placebo group's strength dropped. The trial's main goal, peak power output on a bike, did not differ from placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEndurance after 65.\u003c\/strong\u003e In a 4-month trial in 66 adults aged 65 to 90, half took 1,000 mg a day and half took placebo. Endurance in a hand muscle and a leg muscle (contractions until fatigue) improved with urolithin A compared with placebo at 2 months. The trial's two main goals, 6-minute walk distance and peak muscle energy production, did not differ from placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\"\u003eLiu et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eWhat the research doesn't show\u003c\/h3\u003e\n\u003cp\u003ePlenty, and you should know it. In a 4-week trial in 42 highly trained male distance runners, 1,000 mg a day did not improve 3,000 m time-trial results, though effort ratings and a blood marker of muscle damage after the time trial were lower than with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40839339\/\"\u003eWhitfield et al., 2025\u003c\/a\u003e). If you're 28 and already training hard, this probably isn't your first purchase. The longest trials cited here ran 4 months, so they can't tell you what years of use look like. Every study cited here had co-authors from the company that developed the ingredient they tested. And none of them tested this exact bottle: they tested urolithin A itself at 500 mg and 1,000 mg a day.\u003c\/p\u003e\n\u003ch3\u003eWhy 500 mg in one capsule\u003c\/h3\u003e\n\u003cp\u003e500 mg is the lower of the two daily amounts in the 4-month middle-aged trial, and that group's hamstring strength gain (about 12%) was in the same range as the 1,000 mg group's (9.8%). One honest caveat: the trial in adults over 65 used only 1,000 mg.\u003c\/p\u003e\n\u003ch2\u003eHow to take Urolithin A\u003c\/h2\u003e\n\u003cp\u003eLabel directions: \"Take 1 capsule daily, as a dietary supplement.\"\u003c\/p\u003e\n\u003cp\u003eIn the middle-aged trial, people took urolithin A in the morning before breakfast with water (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). No study has compared timing or food, so pick the time you'll stick with.\u003c\/p\u003e\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, urolithin A included, for identity, potency, heavy metals and microbes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eSee the certificates of analysis for this product\u003c\/a\u003e and match one to the lot number on your bottle.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMade in the USA, in Mt. Angel, Oregon, with globally sourced ingredients.\u003c\/strong\u003e It's a farm town of about 3,500 people in the Willamette Valley, and our UL-certified cGMP facility sits right in it. The people who formulate, make and test this capsule work under one roof, and the owners work in the building too. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003ch3\u003eHow much urolithin A is in each capsule?\u003c\/h3\u003e\n\u003cp\u003eEach capsule contains 500 mg of urolithin A, and the label serving is one capsule a day. With 60 capsules in the bottle, that's a 60-day supply.\u003c\/p\u003e\n\u003ch3\u003eWhen should I take it, and does it need food?\u003c\/h3\u003e\n\u003cp\u003eTake one capsule a day at whatever time you'll remember. The label doesn't name a time, and no study has compared timing or food.\u003c\/p\u003e\n\u003ch3\u003eHow long until I notice something?\u003c\/h3\u003e\n\u003cp\u003eThink months, not days. Urolithin A isn't a stimulant, so there's no jolt to feel. The trials measured muscle endurance at 2 months and strength at 4 months, so give it two to four months of daily use before you judge it.†\u003c\/p\u003e\n\u003ch3\u003eCan't I just eat more pomegranates?\u003c\/h3\u003e\n\u003cp\u003eEat them anyway, but they may not get you much urolithin A. Pomegranates contain the raw material, not urolithin A itself, and only some people's gut bacteria convert it well. A 500 mg serving of urolithin A gave more than six times the exposure of a glass of pomegranate juice (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34117375\/\"\u003eSingh et al., 2021\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eCan I take it with NMN + NR or CoQ10?\u003c\/h3\u003e\n\u003cp\u003eWe haven't found a published trial that tested urolithin A together with NMN, NR or CoQ10, so we can't promise the combination adds up to more. People pair them because they work on different parts of the same system: urolithin A supports recycling worn-out mitochondria, NMN and NR are building blocks for NAD+, which mitochondria use to make energy, and CoQ10 works inside the energy-making chain itself.† Taking medication? Check with your practitioner before combining supplements.\u003c\/p\u003e\n\u003ch3\u003eIs it safe to take with my medication?\u003c\/h3\u003e\n\u003cp\u003eAsk your healthcare practitioner first. The middle-aged trial excluded people taking statins, blood thinners, steroids or thyroid medication, so there is no trial data for those combinations. In the two 4-month trials, adverse events with urolithin A were similar to placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\"\u003eLiu et al., 2022\u003c\/a\u003e; \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\n\u003ch3\u003eIs urolithin A a probiotic?\u003c\/h3\u003e\n\u003cp\u003eNo. It's often called a postbiotic: a compound that gut bacteria make, rather than the bacteria themselves. This capsule contains urolithin A, not live cultures.\u003c\/p\u003e\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/ingredients\/urolithin-a\"\u003eUrolithin A ingredient guide: where it comes from, what the trials measured, and safety\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness, for the NAD+ side of cellular energy\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/coq10-alpha-lipoic-acid\"\u003eCoQ10 + Alpha Lipoic Acid, for the energy-making chain inside mitochondria\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-starter\"\u003eMitochondria Stack Starter: one bottle each of Urolithin A and NMN + NR\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eAndreux PA et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism. 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32694802\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSingh A et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. European Journal of Clinical Nutrition. 2021. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34117375\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLiu S et al. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Network Open. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWhitfield J et al. Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. Sports Medicine. 2025. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40839339\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":51859753042202,"sku":"015-M3200","price":89.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/M3200REV02_ListingImage1.png?v=1774269533"},{"product_id":"mitochondria-stack-starter","title":"Mitochondria Stack Starter – Cellular Energy Support | 1 Bottle Each","description":"\u003cp\u003e\u003cstrong\u003eThe Mitochondria Stack Starter is one 60-capsule bottle of Urolithin A (500 mg per 1-capsule serving) and one 60-capsule bottle of NMN + NR Cellular Wellness (500 mg NMN and 200 mg nicotinamide riboside per 2-capsule serving, with resveratrol, TMG, Bioperine® and zinc). Urolithin A supports mitochondrial renewal, and NMN + NR supports healthy NAD+ levels for cellular energy.† Bundle price: $129.99, versus $149.98 bought separately, so you save $19.99.\u003c\/strong\u003e\u003c\/p\u003e\r\n\u003cp\u003eYour cells run on mitochondria, and keeping them working takes two jobs: clearing out the worn-out ones, and keeping the rest supplied with NAD+, a coenzyme they need to turn food into usable energy. This stack puts one product on each job.† It's built for people in their late 30s and 40s who are already working on energy and cellular health, and for anyone past 50 who plans to keep going strong. Aging isn't optional. Getting old is.\u003c\/p\u003e\r\n\u003ch2\u003eUrolithin A: the cleanup crew\u003c\/h2\u003e\r\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003eUrolithin A\u003c\/a\u003e is a single-ingredient formula: 500 mg of urolithin A in each 1-capsule serving, 60 servings per bottle. The label says it supports mitochondrial renewal, cellular energy, and promotes healthy aging.†\u003c\/p\u003e\r\n\u003cp\u003eYour gut bacteria make urolithin A from ellagitannins, the polyphenols in pomegranates, walnuts and some berries, and how much you make varies a lot from person to person: in one trial, only about 15% of participants had any in their blood at the start (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e). Taking it directly skips that step. In research, it's mainly studied for supporting mitophagy, the process cells use to tag worn-out mitochondria and recycle them so healthier ones carry the load.†\u003c\/p\u003e\r\n\u003cp\u003eIn a 4-month randomized trial in 88 untrained middle-aged adults taking 500 mg or 1,000 mg daily, hamstring strength rose about 12% at 500 mg (about 10% at 1,000 mg) compared with placebo, and muscle samples showed more of the proteins tied to mitophagy and mitochondrial metabolism. The trial's main measure, peak power output, did not improve significantly, and the study was run by the developer of the urolithin A it tested (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003eSingh et al., 2022\u003c\/a\u003e).\u003c\/p\u003e\r\n\u003ch2\u003eNMN + NR Cellular Wellness: the fuel line\u003c\/h2\u003e\r\n\u003cp\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/nmn-nr-cellular-wellness-supplement\"\u003eNMN + NR Cellular Wellness\u003c\/a\u003e comes as 60 capsules, 30 servings of 2 capsules. Each serving contains:\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003eβ-Nicotinamide Mononucleotide: 500 mg\u003c\/li\u003e\r\n\u003cli\u003eResveratrol (from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e) (root): 250 mg\u003c\/li\u003e\r\n\u003cli\u003eNicotinamide riboside: 200 mg\u003c\/li\u003e\r\n\u003cli\u003eTrimethylglycine (TMG) (Betaine anhydrous): 50 mg\u003c\/li\u003e\r\n\u003cli\u003eBioperine® (\u003cem\u003ePiper nigrum\u003c\/em\u003e fruit): 50 mg\u003c\/li\u003e\r\n\u003cli\u003eZinc (as bisglycinate chelate): 10 mg\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003eNMN and NR are vitamin B3 compounds that your body turns into NAD+. Mitochondria use NAD+ to make energy, and enzymes called sirtuins depend on it too. NR is converted into NMN, and NMN becomes NAD+ in one more step, so the formula covers both entry points. The label says it supports cellular energy production and maintains healthy NAD+ levels.†\u003c\/p\u003e\r\n\u003cp\u003eThe supporting cast: resveratrol from Japanese knotweed root (\u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e), TMG (betaine, a methyl donor), Bioperine® from black pepper fruit (\u003cem\u003ePiper nigrum\u003c\/em\u003e), and zinc as a bisglycinate chelate (zinc bound to glycine).\u003c\/p\u003e\r\n\u003cp\u003eIn a 60-day randomized trial in 80 healthy middle-aged adults, NMN at 300, 600 or 900 mg once daily raised blood NAD+ in every dose group, was well tolerated, and increased six-minute walking distance more than placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003eYi et al., 2022\u003c\/a\u003e). In a small 6-week crossover trial in 30 healthy adults aged 55 to 79, NR at 1,000 mg a day (one serving here has 200 mg) was well tolerated and raised NAD+ in blood cells by about 60% compared with placebo (\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003eMartens et al., 2018\u003c\/a\u003e). Each trial tested one ingredient alone, not this formula or this stack.\u003c\/p\u003e\r\n\u003ch2\u003eHow to take them together\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eUrolithin A:\u003c\/strong\u003e Take 1 capsule daily, as a dietary supplement.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eNMN + NR Cellular Wellness:\u003c\/strong\u003e Take 2 capsules daily, as a dietary supplement (a 30-day supply per bottle).\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003eNeither product's directions name a time of day or mention food.\u003c\/p\u003e\r\n\u003cp\u003eAsk your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.\u003c\/p\u003e\r\n\u003ch2\u003eDon't take our word for it\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eVerified by independent labs.\u003c\/strong\u003e ISO 17025-accredited labs check our test results.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eEvery ingredient lot tested before use.\u003c\/strong\u003e Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eIf it misses spec, it doesn't go in a bottle.\u003c\/strong\u003e More than 99% of our tests pass, and the lots that don't are turned away.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for every lot.\u003c\/strong\u003e See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/mt-angel-vitamins-urolithin-a-500mg-cellular-energy-mitochondrial-renewal-60-capsules\"\u003ethe certificates of analysis for Urolithin A\u003c\/a\u003e and \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/reviews\/lab-testing\/nmn-nr-cellular-wellness-supplement\"\u003ethe certificates of analysis for NMN + NR Cellular Wellness\u003c\/a\u003e.\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cstrong\u003eMade in the USA. Made and tested in Mt. Angel, Oregon.\u003c\/strong\u003e Both bottles come out of our UL-certified cGMP facility in a Willamette Valley farm town of about 3,500, where formulators, makers and testers work under one roof and the owners work in the building too. We've been making supplements in Oregon since 1974, and we're not getting old either.\u003c\/p\u003e\r\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\r\n\u003ch3\u003eWhat's the difference between urolithin A and NMN?\u003c\/h3\u003e\r\n\u003cp\u003eThey work on different parts of the same system. Urolithin A supports mitophagy, the recycling of worn-out mitochondria, while NMN and NR are building blocks for NAD+, the coenzyme mitochondria use to make energy.† See \u003ca href=\"https:\/\/learn.mtangelvitamins.com\/compare\/urolithin-a-vs-nmn\"\u003ehow urolithin A and NMN differ\u003c\/a\u003e.\u003c\/p\u003e\r\n\u003ch3\u003eWhy buy the stack instead of the two bottles separately?\u003c\/h3\u003e\r\n\u003cp\u003eThe price. The Starter is $129.99, and the same two bottles bought separately come to $149.98, so you save $19.99. They're the same products with the same labels.\u003c\/p\u003e\r\n\u003ch3\u003eHow soon will I notice anything?\u003c\/h3\u003e\r\n\u003cp\u003eThere's no set timeline, and many changes researchers track are measured in a lab, not felt. The trials above ran from 6 weeks to 4 months, so judge it on steady daily use, not one week.\u003c\/p\u003e\r\n\u003ch3\u003eCan I take this stack with medication?\u003c\/h3\u003e\r\n\u003cp\u003eAsk your healthcare practitioner first, and bring both labels along.\u003c\/p\u003e\r\n\u003ch2\u003eKeep learning\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/urolithin-a-complete-guide\"\u003eThe full guide to urolithin A: dose, trials and safety\u003c\/a\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/learn.mtangelvitamins.com\/health\/nad-longevity-complete-guide\"\u003eHow NAD+ works and what NMN and NR do\u003c\/a\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003ca href=\"https:\/\/www.mtangelvitamins.com\/products\/mitochondria-stack-double\"\u003eMitochondria Stack Double, 2 bottles of each\u003c\/a\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch2\u003eReferences\u003c\/h2\u003e\r\n\u003col\u003e\r\n\u003cli\u003eSingh A et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eYi L et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2022. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482258\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eMartens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29599478\/\"\u003ePubMed\u003c\/a\u003e\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003cp\u003e\u003cem\u003e†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mt. Angel Vitamins","offers":[{"title":"Default Title","offer_id":52626906448154,"sku":"MITO-STACK-1M","price":129.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/7869\/files\/22ee0c8d4d34e9cd2218d5b90cfc3978.jpg?v=1785694676"}],"url":"https:\/\/www.mtangelvitamins.com\/collections\/supplements-starting-in-your-40s.oembed","provider":"Mt. Angel Vitamins","version":"1.0","type":"link"}