3-in-1 Probiotic Fusion – Pre, Pro & Postbiotic Gut Support | 30 or 60 Capsules

3-in-1 Probiotic Fusion puts a prebiotic, a probiotic and a postbiotic in one vegetarian capsule: 13 lactobacillus and bifidobacterium cultures adding up to about 20 billion CFU, 100 mg of FOS (fructooligosaccharides), 5 billion TFU of Akkermansia muciniphila postbiotic and 25 mg of champignon mushroom extract. You take one capsule a day, from a bottle of 30 or 60, to support healthy digestion and gut balance.†

This one is for adults who'd rather take one capsule than three bottles. Most gut routines mean buying a probiotic, then a fiber, then wondering about the postbiotic everyone keeps mentioning. Here all three share a single capsule you take with breakfast or lunch.

Building habits in your 30s and 40s that you plan to keep for decades? A daily probiotic is one of the easy ones. It isn't a fix for anything, and below we're straight with you about where the research is solid and where it runs thin.

Why people take 3-in-1 Probiotic Fusion

• Supports digestive balance with 13 probiotic cultures, about 20 billion CFU in every capsule.†
• Supports regular, comfortable digestion as part of a daily routine.†
• Supplies 100 mg of FOS, a prebiotic fiber that bifidobacteria use as food.†
• Adds 5 billion TFU of Akkermansia muciniphila postbiotic, from a microbe that lives in the gut's mucus layer, to support a healthy gut lining.†

What's in each serving

*Daily Value not established.

Serving size is 1 Vegetarian Capsule, so the 30-count bottle is a 30-day supply and the 60-count bottle a 60-day supply at the label's serving. The label lists each culture rather than a total; added up, the 13 amounts come to 20.05 billion CFU. Other ingredients: Vegetable cellulose (preservative-free, from capsule shell), cellulose, silica, and L-leucine. The label states: "NO corn, soy, salt, yeast, gluten, milk & egg products, sugar, starch, or preservatives."

How 3-in-1 Probiotic Fusion works

The probiotic: 13 cultures, about 20 billion CFU

Probiotics are live microbes taken in amounts meant to do you some good. CFU (colony forming units) counts cells that can still grow, the right measure for something that's supposed to be alive. Almost half the total comes from the two cultures with strain codes on the label, L. rhamnosus LRa-05 (5 billion CFU) and L. reuteri LR08 (4 billion). Looking them up? Since a 2020 renaming, recent papers call them Lacticaseibacillus rhamnosus and Limosilactobacillus reuteri. Same bacteria, longer names.

What the research shows: a review of 45 trials in healthy adults found that probiotics raised levels of the specific bacteria people took, with support for better stool consistency and bowel movements. The rise was temporary, and the review found no support for lasting changes to the gut microbiota (a review of probiotics in healthy adults). Those trials used many different strains, not this formula. Because the rise didn't last, a probiotic works as a daily habit, not a one-time fix.†

The prebiotic: 100 mg of FOS

FOS are short chains of fructose your small intestine can't digest. They reach the colon intact, where bacteria ferment them, and bifidobacteria are especially fond of them. That makes FOS a prebiotic: food for the microbes rather than for you.†

The candid part: in a one-week trial, 40 healthy volunteers took 0 to 20 grams of short-chain FOS a day. Bifidobacteria rose significantly at 10 grams, and 20 grams brought noticeably more gas (a dose-response trial of FOS in healthy volunteers). The 100 mg here is one percent of that 10 grams, a little food packed in with the bacteria, not a fiber supplement.

The postbiotic: 5 billion TFU of Akkermansia muciniphila

An international expert panel defined a postbiotic as a preparation of non-living microbes, or their parts, that gives a health benefit to the person who takes it (the expert consensus definition of postbiotics). So unlike the probiotics, the Akkermansia here isn't meant to be alive. It's counted in TFU (total fluorescent units): cells are stained and counted one by one by a flow cytometer, alive or not, while CFU only counts cells that can still grow.

Akkermansia muciniphila was first described in 2004, after researchers isolated it from human stool using mucin as its only food source (the original description of Akkermansia muciniphila). Mucin is the main building block of the mucus layer that lines your gut. Why would a non-living cell matter? In lab tests on human cells, a protein from Akkermansia's outer surface, Amuc_1100, made layers of gut-lining cells hold together more tightly (a lab study of an Akkermansia surface protein). That's cell-culture work, not a human trial.†

For context on amount: in 2021 the European Food Safety Authority's nutrition panel concluded that a pasteurized Akkermansia muciniphila ingredient is safe at up to 34 billion cells a day for adults, not including pregnant or breastfeeding women (the EFSA safety opinion on pasteurized Akkermansia). That opinion covered that specific ingredient, not this capsule, which has 5 billion TFU per serving. Human research on what Akkermansia does is still early, so we stick to what the label and the studies above show.

Champignon extract and the rest

Champignon is French for mushroom; here it's the everyday button mushroom, Agaricus bisporus, as 25 mg of a 100:1 extract the label equates to 2,500 mg of mushroom. Human research on it is thin, so we don't attach a benefit claim to it. Cellulose fills out the capsule, and silica and L-leucine, an amino acid, keep the powder flowing through the capsule machine.

How to take 3-in-1 Probiotic Fusion

Label directions: "Take one capsule daily with the morning or noonday meal, as a dietary supplement."

Pick breakfast or lunch and take it with that same meal each day, so it's easy to remember.

Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.

Don't take our word for it

• Verified by independent labs. ISO 17025-accredited labs check our test results.
• Every ingredient lot tested before use. Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.
• If it misses spec, it doesn't go in a bottle. More than 99% of our tests pass, and the lots that don't are turned away.
• A certificate of analysis for every lot. Every lot of 3-in-1 Probiotic Fusion gets its own.

Made in the USA with globally sourced ingredients, in Mt. Angel, Oregon. It's a farm town of about 3,500 people in the Willamette Valley, and our UL-certified cGMP facility is where this capsule is formulated, made and tested, with the formulators, makers and testers all under one roof. The owners work in the building too, and have run the company since 2017. We've been making supplements in Oregon since 1974. That's 52 years, and we're not getting old either.

Frequently asked questions

How many CFU are in 3-in-1 Probiotic Fusion?

Each capsule has about 20 billion CFU from 13 lactobacillus and bifidobacterium cultures, or 20.05 billion when you add up the label's amounts.

When should I take it?

Take one capsule a day with your morning or noonday meal, as the label directs. Pick whichever meal you'll remember.

What's the difference between a prebiotic, a probiotic and a postbiotic?

A probiotic is live bacteria, a prebiotic is food for those bacteria, and a postbiotic is a non-living microbial preparation. Here that's the 13 cultures, the FOS and the Akkermansia.

How long until I notice anything?

We can't give you a timeline, because no study of this exact formula sets one. Take it daily and pay attention to how your digestion feels over the following weeks. In the review of healthy adults, the rise in supplied bacteria was temporary, so the daily habit is the point.

Does it contain milk, soy or gluten?

No, according to the label, which states "NO corn, soy, salt, yeast, gluten, milk & egg products, sugar, starch, or preservatives." The capsule is vegetarian.

Can I take it with Super Enzymes+ or Betaine HCl?

They do different jobs, and all three labels say to take them with a meal. Super Enzymes+ is a digestive enzyme blend taken with each meal, and Betaine HCl is a source of hydrochloric acid taken with or right after a meal, while this capsule supplies bacteria and their food. Follow each label's directions, and if you take medication or have a medical condition, check the combination with your healthcare practitioner first.

Is it safe with my medication, or while pregnant?

Ask your healthcare practitioner first. That goes double for pregnancy and breastfeeding, since European food-safety reviewers left those groups out of their safety conclusion on pasteurized Akkermansia.

Keep learning

• How we source and test raw materials before they reach a bottle
• Super Enzymes+, a digestive enzyme blend for fats, proteins and carbs
• Betaine HCl, a source of hydrochloric acid taken with meals

References

1. Khalesi S et al. A review of probiotic supplementation in healthy adults: helpful or hype? European journal of clinical nutrition. 2019. PubMed
2. Bouhnik Y et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. The Journal of nutrition. 1999. PubMed
3. Salminen S et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nature reviews. Gastroenterology & hepatology. 2021. PubMed
4. Derrien M et al. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. International journal of systematic and evolutionary microbiology. 2004. PubMed
5. Ottman N et al. Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function. PloS one. 2017. PubMed
6. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) et al. Safety of pasteurised Akkermansia muciniphila as a novel food pursuant to Regulation (EU) 2015/2283. EFSA journal. European Food Safety Authority. 2021. PubMed

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.