Joint Solution Advanced with Hyaluronic Acid & MSM – Joint Comfort | 60 Capsules
Joint Solution Advanced is a joint support supplement with 1,000 mg of glucosamine, 700 mg of MSM, 70 mg of hyaluronic acid and 50 mg of collagen type II in every 4-capsule serving, plus boswellia, bromelain, quercetin, Curcumin C³ Complex®, devil's claw and alfalfa. Each bottle holds 60 capsules (15 servings). It supports joint comfort and joint fluidity.†
This one is for people who plan to keep moving: hikers, lifters, gardeners, weekend pickleball players. It builds on our original Joint Solution formula with 700 mg of MSM, 70 mg of hyaluronic acid and more boswellia, so the structural ingredients and the botanicals share one bottle.
You don't have to wait for your 60s to think about your joints. Start in your 30s and 40s, while you're still putting in the miles and the reps. Aging isn't optional. Getting old is.
Why people take Joint Solution Advanced
- Supports joint comfort and joint fluidity, the two jobs printed on the label.†
- Delivers 1,000 mg of glucosamine, a building block your body uses to make cartilage, to support normal joint structure.†
- Adds 70 mg of hyaluronic acid, a natural part of the fluid that cushions your joints.†
- Includes 700 mg of MSM, a sulfur compound studied in healthy, active men for post-workout recovery.†
- Covers joint structure and the botanicals in one daily routine: ten ingredients, one bottle.†
What's in each serving
| Ingredient | Amount per serving | % Daily Value |
|---|---|---|
| Total Glucosamine (from crab shell) (from 750 mg glucosamine HCl & 250 mg glucosamine sulfate) | 1,000 mg | Not established |
| MSM (methyl sulfonyl methane) | 700 mg | Not established |
| Boswellia serrata Extract | 400 mg | Not established |
| Bromelain (1200 GDU/g, from Ananas comosus fruit) | 200 mg | Not established |
| Quercetin | 200 mg | Not established |
| Curcumin C³ Complex® | 100 mg | Not established |
| Devil's Claw Root (Harpagophytum procumbens) | 100 mg | Not established |
| Alfalfa Herb (Medicago sativa) | 100 mg | Not established |
| Hyaluronic Acid | 70 mg | Not established |
| Collagen Type II (contains 20% chondroitin sulfate) | 50 mg | Not established |
Serving size: 4 capsules. Servings per container: 15. Other ingredients: Vegetable cellulose (preservative-free, from capsule shell), organic rice concentrate, and organic rice extract. The label states: "NO corn, soy, salt, yeast, gluten, milk & egg products, sugar, starch, or preservatives." It also states: "Contains Glucosamine, isolated from crab shell."
How Joint Solution Advanced works
Glucosamine: 1,000 mg from crab shell
Glucosamine is an amino sugar your body makes and uses to build the long molecules that give cartilage its bounce. Here it's isolated from crab shell, in two common forms: 750 mg of glucosamine HCl and 250 mg of glucosamine sulfate.
What the research shows: in a 16-week randomized, placebo-controlled trial in 43 college soccer players, a supplement providing 2 grams of glucosamine a day lowered a urine marker of type II collagen breakdown (type II is the main collagen in cartilage) below the placebo group, while a collagen-building marker held steady, with no supplement-related side effects. What it doesn't show: these were lab markers in young athletes, not how anyone's knees felt, at twice the glucosamine in one serving here.
Hyaluronic acid (70 mg) and collagen type II (50 mg)
Hyaluronic acid is a long sugar chain your body makes to hold water, and it's what makes the fluid inside your joints slick and cushiony. It's here to support joint fluidity.† A study of orally given hyaluronan in rats found gut bacteria break it into smaller pieces that are absorbed in the large intestine and reach tissues such as skin. That's animal data, and it shows absorption, not anything about joints.
The 50 mg of collagen type II contains 20% chondroitin sulfate, about 10 mg of chondroitin. That's not much, so we don't call this a chondroitin supplement.
MSM: 700 mg
MSM (methylsulfonylmethane) is a sulfur compound found in small amounts in many foods. A review of MSM's uses and safety notes it is Generally Recognized As Safe (GRAS) and well tolerated by most people at up to 4 grams a day, with few, mild side effects.
In a 30-day pilot study in 8 healthy, moderately active men taking 1.5 or 3 grams a day, soreness after a hard leg workout trended lower on the higher dose, and blood antioxidant capacity rose after exercise at 3 grams.† Straight talk: 8 people, trends rather than firm results, at doses at least twice our 700 mg. For more MSM, MSM 2000 has 2,000 mg in one tablet.
Boswellia, Curcumin C³ Complex® and devil's claw
Boswellia serrata extract (400 mg) comes from a tree resin also called Indian frankincense, best known for its boswellic acids. Devil's claw (100 mg) is a root from southern Africa. Curcumin C³ Complex® (100 mg) is a turmeric extract that, per the label, is at least 95% curcuminoids.
One honest limit: curcumin on its own is poorly absorbed and quickly cleared, as a review of curcumin bioavailability lays out, and this formula has no absorption helper like black pepper extract, so think of it as a supporting amount. The label doesn't list a standardization for the boswellia or devil's claw, so we don't borrow results from studies of branded extracts.
Bromelain, quercetin and alfalfa
Bromelain is a group of protein-digesting enzymes from pineapple: 200 mg at 1200 GDU/g (a measure of enzyme activity). In a study of bromelain absorption in 19 healthy men, a small amount of intact bromelain reached the blood after it was taken by mouth and kept at least part of its enzyme activity. Its repeat-dose phase used 3 grams a day, many times our 200 mg, and measured absorption, not joints. Quercetin (200 mg) is a plant flavonoid studied for its antioxidant activity, and alfalfa herb (100 mg) is the above-ground part of the alfalfa plant. We don't make separate claims for these supporting players.
How to take Joint Solution Advanced
The label says: "One to two capsules twice daily, as a dietary supplement."
The amounts in the table are for the label's 4-capsule serving. The label doesn't name a time of day or mention food; breakfast and dinner make both doses easy to remember.
If you avoid shellfish, skip this one: the glucosamine is isolated from crab shell.
Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.
Don't take our word for it
- Verified by independent labs. ISO 17025-accredited labs check our test results.
- Every ingredient lot tested before use. Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, from the crab-shell glucosamine to the devil's claw root, for identity, potency, heavy metals and microbes.
- If it misses spec, it doesn't go in a bottle. More than 99% of our tests pass, and the lots that don't are turned away.
- A certificate of analysis for every lot. Every lot of Joint Solution Advanced has its own.
Made in the USA. Made and tested in Mt. Angel, Oregon. It's a farm town of about 3,500 people in the Willamette Valley, and our UL-certified cGMP facility there keeps formulators, makers and testers under one roof. The owners work in the building too, and the company has been owner-run since 2017. We've been making supplements in Oregon since 1974. We're not getting old either.
Frequently asked questions
How many capsules of Joint Solution Advanced do I take a day?
The label says one to two capsules twice daily. The Supplement Facts serving size is 4 capsules, which provides 1,000 mg of glucosamine, 700 mg of MSM and 70 mg of hyaluronic acid.
How many servings are in a bottle?
The label lists 15 servings of 4 capsules in each 60-capsule bottle.
How is it different from the original Joint Solution?
Advanced adds 700 mg of MSM and 70 mg of hyaluronic acid and has 400 mg of boswellia instead of 300 mg. Both list 750 mg of glucosamine HCl, 250 mg of glucosamine sulfate, 50 mg of collagen type II, and the same amounts of bromelain, quercetin, Curcumin C³ Complex®, devil's claw and alfalfa. The original adds 25 mg of yucca root extract and uses a gelatin capsule; Advanced uses vegetable cellulose. For the simpler formula, see the original Joint Solution.
Is Joint Solution Advanced vegetarian or shellfish-free?
No to both. The glucosamine is isolated from crab shell, and collagen is an animal protein, even though the capsule shell is vegetable cellulose.
How long until I notice anything?
There's no set timeline; neither the label nor the research cited above gives one. The glucosamine trial ran 16 weeks and measured lab markers, not how joints feel, so give it a few months of steady use before you judge it.
Can I take it with Inflameze or MSM 2000?
Yes, they're sold together in our Joint + Mobility Stack, but know your totals. One MSM 2000 tablet plus a 4-capsule serving here is 2,700 mg of MSM a day, within the up-to-4-gram range the safety review above calls well tolerated by most people. Inflameze repeats several botanicals from this formula (boswellia, bromelain, quercetin, Curcumin C³ Complex®, devil's claw and alfalfa), so follow each label.
Is it safe to take with my medication?
Ask your healthcare practitioner before you start, and bring the bottle so they can see the full ingredient list.
Keep learning
- The original Joint Solution formula, without MSM or hyaluronic acid
- MSM 2000, with 2,000 mg of MSM per tablet
- The Joint + Mobility Stack: this formula, Inflameze and MSM 2000
References
- Tsuruta A et al. Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study. Mol Med Rep. 2018. PubMed
- Kimura M et al. Absorption of Orally Administered Hyaluronan. J Med Food. 2016. PubMed
- Butawan M et al. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients. 2017. PubMed
- Kalman DS et al. Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study. J Int Soc Sports Nutr. 2012. PubMed
- Anand P et al. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007. PubMed
- Castell JV et al. Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake. Am J Physiol. 1997. PubMed
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
